Open Access
Beilstein Journal of Nanotechnology, volume 10, pages 1964-1972
Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents
Gervits N. E.
1
,
Abakumov Maxim A.
,
Vasiliev Alexander L.
,
Chekhonin Vladimir P
,
Gippius Andrey A
2
,
Demikhov E I
2
,
Starchikov Sergey S
,
Lyubutin Igor S.
,
Semkina Alevtina S.
3, 4
,
Mazhuga Alexander G
4
,
Tkachev Alexey
2
,
STARCHIKOV S.S.
1
,
LYUBUTIN I.S.
1
,
Vasiliev Alexander
5, 6
,
Чехонин В. П.
7
,
Abakumov Maxim A.
3, 4
1
5
Publication type: Journal Article
Publication date: 2019-10-02
Journal:
Beilstein Journal of Nanotechnology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.1
ISSN: 21904286
PubMed ID:
31667044
General Physics and Astronomy
General Materials Science
Electrical and Electronic Engineering
Abstract
Background: One of the future applications of magnetic nanoparticles is the development of new iron-oxide-based magnetic resonance imaging (MRI) negative contrast agents, which are intended to improve the results of diagnostics and complement existing Gd-based contrast media.
Results: Iron oxide nanoparticles designed for use as MRI contrast media are precisely examined by a variety of methods: powder X-ray diffraction (XRD), transmission electron microscopy (TEM), Raman spectroscopy, Mössbauer spectroscopy and zero-field nuclear magnetic resonance (ZF-NMR) spectroscopy. TEM and XRD measurements reveal a spherical shape of the nanoparticles with an average diameter of 5–8 nm and a cubic spinel-type crystal structure of space group Fd−3m. Raman, Mössbauer and NMR spectroscopy clearly indicate the presence of the maghemite γ-Fe2O3 phase. Moreover, a difference in the magnetic behavior of uncoated and human serum albumin coated iron oxide nanoparticles was observed by Mössbauer spectroscopy.
Conclusion: This difference in magnetic behavior is explained by the influence of biofunctionalization on the magnetic and electronic properties of the iron oxide nanoparticles. The ZF-NMR spectra analysis allowed us to determine the relative amount of iron located in the core and the surface layer of the nanoparticles. The obtained results are important for understanding the structural and magnetic properties of iron oxide nanoparticles used as T2 contrast agents for MRI.
Citations by journals
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2
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Journal of Magnetism and Magnetic Materials
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Journal of Magnetism and Magnetic Materials
2 publications, 12.5%
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Beilstein Journal of Nanotechnology
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Beilstein Journal of Nanotechnology
1 publication, 6.25%
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Materials Today Communications
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1 publication, 6.25%
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1 publication, 6.25%
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Materials
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Materials
1 publication, 6.25%
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Molecules
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Molecules
1 publication, 6.25%
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Journal of Cluster Science
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Journal of Cluster Science
1 publication, 6.25%
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Journal of Porous Materials
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Journal of Porous Materials
1 publication, 6.25%
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Journal of Controlled Release
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Journal of Controlled Release
1 publication, 6.25%
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ACS applied materials & interfaces
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ACS applied materials & interfaces
1 publication, 6.25%
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Photonics
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Photonics
1 publication, 6.25%
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Applied Sciences (Switzerland)
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1 publication, 6.25%
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Physical Chemistry Chemical Physics
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1 publication, 6.25%
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Nanomedicine and Nanotoxicology
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1 publication, 6.25%
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1
2
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Citations by publishers
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1
2
3
4
5
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Elsevier
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Elsevier
5 publications, 31.25%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 25%
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Springer Nature
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Springer Nature
3 publications, 18.75%
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Beilstein-Institut
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Beilstein-Institut
1 publication, 6.25%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 6.25%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
1 publication, 6.25%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Gervits N. E. et al. Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents // Beilstein Journal of Nanotechnology. 2019. Vol. 10. pp. 1964-1972.
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Gippius A. A., Mazhuga A. G., Semkina A. S., Abakumov M. A., Chekhonin V. P., Vasiliev A. L., Lyubutin I. S., Starchikov S. S., Demikhov E. I., Tkachev A. V., Gervits N. E., Tkachev A., STARCHIKOV S., LYUBUTIN I., Vasiliev A., Чехонин В. П., Abakumov M. A. Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents // Beilstein Journal of Nanotechnology. 2019. Vol. 10. pp. 1964-1972.
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TY - JOUR
DO - 10.3762/bjnano.10.193
UR - https://doi.org/10.3762%2Fbjnano.10.193
TI - Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents
T2 - Beilstein Journal of Nanotechnology
AU - Gervits, N. E.
AU - Gippius, Andrey A
AU - Tkachev, Alexey V.
AU - Demikhov, E I
AU - Starchikov, Sergey S
AU - Lyubutin, Igor S.
AU - Vasiliev, Alexander L.
AU - Chekhonin, Vladimir P
AU - Abakumov, Maxim A.
AU - Semkina, Alevtina S.
AU - Mazhuga, Alexander G
AU - Tkachev, Alexey
AU - STARCHIKOV, S.S.
AU - LYUBUTIN, I.S.
AU - Vasiliev, Alexander
AU - Чехонин, В. П.
AU - Abakumov, Maxim A.
PY - 2019
DA - 2019/10/02 00:00:00
PB - Beilstein-Institut
SP - 1964-1972
VL - 10
PMID - 31667044
SN - 2190-4286
ER -
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@article{2019_Gervits,
author = {N. E. Gervits and Andrey A Gippius and Alexey V. Tkachev and E I Demikhov and Sergey S Starchikov and Igor S. Lyubutin and Alexander L. Vasiliev and Vladimir P Chekhonin and Maxim A. Abakumov and Alevtina S. Semkina and Alexander G Mazhuga and Alexey Tkachev and S.S. STARCHIKOV and I.S. LYUBUTIN and Alexander Vasiliev and В. П. Чехонин and Maxim A. Abakumov},
title = {Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents},
journal = {Beilstein Journal of Nanotechnology},
year = {2019},
volume = {10},
publisher = {Beilstein-Institut},
month = {oct},
url = {https://doi.org/10.3762%2Fbjnano.10.193},
pages = {1964--1972},
doi = {10.3762/bjnano.10.193}
}