International Journal of Molecular Medicine, volume 39, issue 2, pages 347-356
The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration
Publication type: Journal Article
Publication date: 2017-01-11
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.4
ISSN: 11073756, 1791244X
PubMed ID:
28075444
General Medicine
Genetics
Abstract
Exploring the biological functions of long non-coding RNAs (lncRNAs) has come to the foreground in recent years. Studies have indicated that the lncRNA metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) not only regulates tumorigenesis in hepatocellular carcinoma, but also controls cell cycle progression in hematopoietic cells. The present study was designed to investigate the biological role of lncRNA MALAT1 in liver regeneration. We carried out a series of assays during liver regeneration following 2/3 partial hepatectomy in mice. We explored the functions of lncRNA MALAT1 with a series of functional analyses in vitro. We found that MALAT1 was upregulated during liver regeneration. Moreover, MALAT1 accelerated hepatocyte proliferation by stimulating cell cycle progression from the G1 to the S phase and inhibiting apoptosis in vitro. In addition, our findings also demonstrated that MALAT1 was regulated by p53 during liver regeneration, and that p53 may be a key upstream regulator of MALAT1 activity. Mechanistically, we found that MALAT1 activated the Wnt/β‑catenin pathway by inhibiting the expression of Axin1 and adenomatous polyposis coli (APC), and subsequently promoting the expression of cyclin D1. On the whole, the findings of this study suggest that MALAT1 is a critical molecule for liver regeneration. Pharmacological interventions targeting MALAT1 may thus prove to be therapeutically beneficial in liver failure or liver transplantation by promoting liver regeneration.
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Li C. et al. The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration // International Journal of Molecular Medicine. 2017. Vol. 39. No. 2. pp. 347-356.
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Li C., Chang L., Chen Z., Liu Z., Wang Y., Ye Q. The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration // International Journal of Molecular Medicine. 2017. Vol. 39. No. 2. pp. 347-356.
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TY - JOUR
DO - 10.3892/ijmm.2017.2854
UR - https://doi.org/10.3892%2Fijmm.2017.2854
TI - The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration
T2 - International Journal of Molecular Medicine
AU - Li, Cui-Cui
AU - Chang, Lei
AU - Chen, Zhiquan
AU - Liu, Zhongzhong
AU - Wang, Yanfeng
AU - Ye, Qi-Fa
PY - 2017
DA - 2017/01/11 00:00:00
PB - Spandidos Publications
SP - 347-356
IS - 2
VL - 39
PMID - 28075444
SN - 1107-3756
SN - 1791-244X
ER -
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@article{2017_Li
author = {Cui-Cui Li and Lei Chang and Zhiquan Chen and Zhongzhong Liu and Yanfeng Wang and Qi-Fa Ye},
title = {The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration},
journal = {International Journal of Molecular Medicine},
year = {2017},
volume = {39},
publisher = {Spandidos Publications},
month = {jan},
url = {https://doi.org/10.3892%2Fijmm.2017.2854},
number = {2},
pages = {347--356},
doi = {10.3892/ijmm.2017.2854}
}
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MLA
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Li, Cui-Cui, et al. “The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration.” International Journal of Molecular Medicine, vol. 39, no. 2, Jan. 2017, pp. 347-356. https://doi.org/10.3892%2Fijmm.2017.2854.