Open Access
Neural Regeneration Research, volume 12, issue 3, pages 358
Telomerase and mTOR in the brain: the mitochondria connection
Publication type: Journal Article
Publication date: 2017-03-24
Journal:
Neural Regeneration Research
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 6.1
ISSN: 16735374, 18767958
PubMed ID:
28469639
Developmental Neuroscience
Abstract
Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA component. Additionally, the protein part TERT (Telomerase Reverse Transcriptase) has various non-canonical functions. For example, it can localize to mitochondria under increased stress and protect cells in vitro from oxidative stress, DNA damage and apoptosis. Recently it has been demonstrated that TERT protein persists in adult neurons in the brain and data emerge suggesting that it might have a protective function in these post-mitotic cells as well. We have recently published that TERT protein accumulated in mitochondria from brain tissue of mice that have undergone short-term dietary restriction (DR) and rapamycin treatment. This localization correlated to lower levels of oxidative stress in these brain mitochondria. Since rapamycin treatment decreases mTOR signaling which is also thought to play an important role for the beneficial effects of DR, we conclude that the mTOR pathway might be involved in the TERT localization and its effects in brain mitochondria in vivo. These data are in line with previous findings from our group about increased mitochondrial localization of TERT in Alzheimer's disease (AD) brains and a protective function of TERT protein in neurons in vitro against pathological tau.
Citations by journals
1
2
|
|
Neural Regeneration Research
|
Neural Regeneration Research
2 publications, 10%
|
Nucleic Acids Research
|
Nucleic Acids Research
1 publication, 5%
|
Current Aging Science
|
Current Aging Science
1 publication, 5%
|
Current Topics in Medicinal Chemistry
|
Current Topics in Medicinal Chemistry
1 publication, 5%
|
Rejuvenation Research
|
Rejuvenation Research
1 publication, 5%
|
Frontiers in Cell and Developmental Biology
|
Frontiers in Cell and Developmental Biology
1 publication, 5%
|
Stem Cell Reviews and Reports
|
Stem Cell Reviews and Reports
1 publication, 5%
|
Molecular Neurobiology
|
Molecular Neurobiology
1 publication, 5%
|
BBA Advances
|
BBA Advances
1 publication, 5%
|
Pharmacological Research
|
Pharmacological Research
1 publication, 5%
|
Alzheimer's and Dementia
|
Alzheimer's and Dementia
1 publication, 5%
|
Phytotherapy Research
|
Phytotherapy Research
1 publication, 5%
|
Biotechnic and Histochemistry
|
Biotechnic and Histochemistry
1 publication, 5%
|
Cancer Investigation
|
Cancer Investigation
1 publication, 5%
|
Journal of Neuroscience
|
Journal of Neuroscience
1 publication, 5%
|
Biomedicine and Pharmacotherapy
|
Biomedicine and Pharmacotherapy
1 publication, 5%
|
Cancer Reports
|
Cancer Reports
1 publication, 5%
|
1
2
|
Citations by publishers
1
2
3
|
|
Elsevier
|
Elsevier
3 publications, 15%
|
Wiley
|
Wiley
3 publications, 15%
|
Bentham Science
|
Bentham Science
2 publications, 10%
|
Springer Nature
|
Springer Nature
2 publications, 10%
|
Taylor & Francis
|
Taylor & Francis
2 publications, 10%
|
Wolters Kluwer Health
|
Wolters Kluwer Health
2 publications, 10%
|
Oxford University Press
|
Oxford University Press
1 publication, 5%
|
Mary Ann Liebert
|
Mary Ann Liebert
1 publication, 5%
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 5%
|
Society for Neuroscience
|
Society for Neuroscience
1 publication, 5%
|
1
2
3
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0],"imageUrls":["","","","","","",""],"datasets":[{"label":"Citations number","data":[4,7,3,1,2,2,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["20","35","15","5","10","10","5"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Neural Regeneration Research","Nucleic Acids Research","Current Aging Science","Current Topics in Medicinal Chemistry","Rejuvenation Research","Frontiers in Cell and Developmental Biology","Stem Cell Reviews and Reports","Molecular Neurobiology","BBA Advances","Pharmacological Research","Alzheimer's and Dementia","Phytotherapy Research","Biotechnic and Histochemistry","Cancer Investigation","Journal of Neuroscience","Biomedicine and Pharmacotherapy","Cancer Reports"],"ids":[20777,23904,18998,3277,17463,12128,11731,24041,31779,4321,10478,20081,5280,775,23913,23951,28605],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/oK3sRIFs7jTQfHhJn9GNyct1rmZrCIj9Rn5x9It5_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[10,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Wiley","Bentham Science","Springer Nature","Taylor & Francis","Wolters Kluwer Health","Oxford University Press","Mary Ann Liebert","Frontiers Media S.A.","Society for Neuroscience"],"ids":[17,11,39,8,18,32,19,230,208,3127],"codes":[0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/6QE8LXWrLpkoy5A2te6hw7who46GeCoTYIstuoAz_medium.webp","\/storage\/images\/resized\/yNSijlgQghQF53VZuyFLA30CKDe4j3HK74Vtpnxa_medium.webp","\/storage\/images\/resized\/Zy5YST233rzRbZP24I24MzZm64hz20ZV9qQopmMn_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/oK3sRIFs7jTQfHhJn9GNyct1rmZrCIj9Rn5x9It5_medium.webp"],"datasets":[{"label":"","data":[3,3,2,2,2,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[15,15,10,10,10,10,5,5,5,5],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Saretzki G., Miwa S. Telomerase and mTOR in the brain: the mitochondria connection // Neural Regeneration Research. 2017. Vol. 12. No. 3. p. 358.
GOST all authors (up to 50)
Copy
Saretzki G., Miwa S. Telomerase and mTOR in the brain: the mitochondria connection // Neural Regeneration Research. 2017. Vol. 12. No. 3. p. 358.
Cite this
RIS
Copy
TY - JOUR
DO - 10.4103/1673-5374.202922
UR - https://doi.org/10.4103%2F1673-5374.202922
TI - Telomerase and mTOR in the brain: the mitochondria connection
T2 - Neural Regeneration Research
AU - Saretzki, G
AU - Miwa, S
PY - 2017
DA - 2017/03/24 00:00:00
PB - Wolters Kluwer Health
SP - 358
IS - 3
VL - 12
PMID - 28469639
SN - 1673-5374
SN - 1876-7958
ER -
Cite this
BibTex
Copy
@article{2017
author = {G Saretzki and S Miwa},
title = {Telomerase and mTOR in the brain: the mitochondria connection},
journal = {Neural Regeneration Research},
year = {2017},
volume = {12},
publisher = {Wolters Kluwer Health},
month = {mar},
url = {https://doi.org/10.4103%2F1673-5374.202922},
number = {3},
pages = {358},
doi = {10.4103/1673-5374.202922}
}