Open Access
Open access
Neural Regeneration Research, volume 12, issue 3, pages 358

Telomerase and mTOR in the brain: the mitochondria connection

Saretzki G., Miwa S.
Publication typeJournal Article
Publication date2017-03-24
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor6.1
ISSN16735374, 18767958
Developmental Neuroscience
Abstract
Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA component. Additionally, the protein part TERT (Telomerase Reverse Transcriptase) has various non-canonical functions. For example, it can localize to mitochondria under increased stress and protect cells in vitro from oxidative stress, DNA damage and apoptosis. Recently it has been demonstrated that TERT protein persists in adult neurons in the brain and data emerge suggesting that it might have a protective function in these post-mitotic cells as well. We have recently published that TERT protein accumulated in mitochondria from brain tissue of mice that have undergone short-term dietary restriction (DR) and rapamycin treatment. This localization correlated to lower levels of oxidative stress in these brain mitochondria. Since rapamycin treatment decreases mTOR signaling which is also thought to play an important role for the beneficial effects of DR, we conclude that the mTOR pathway might be involved in the TERT localization and its effects in brain mitochondria in vivo. These data are in line with previous findings from our group about increased mitochondrial localization of TERT in Alzheimer's disease (AD) brains and a protective function of TERT protein in neurons in vitro against pathological tau.

Citations by journals

1
2
Neural Regeneration Research
Neural Regeneration Research, 2, 10%
Neural Regeneration Research
2 publications, 10%
Nucleic Acids Research
Nucleic Acids Research, 1, 5%
Nucleic Acids Research
1 publication, 5%
Current Aging Science
Current Aging Science, 1, 5%
Current Aging Science
1 publication, 5%
Current Topics in Medicinal Chemistry
Current Topics in Medicinal Chemistry, 1, 5%
Current Topics in Medicinal Chemistry
1 publication, 5%
Rejuvenation Research
Rejuvenation Research, 1, 5%
Rejuvenation Research
1 publication, 5%
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, 1, 5%
Frontiers in Cell and Developmental Biology
1 publication, 5%
Stem Cell Reviews and Reports
Stem Cell Reviews and Reports, 1, 5%
Stem Cell Reviews and Reports
1 publication, 5%
Molecular Neurobiology
Molecular Neurobiology, 1, 5%
Molecular Neurobiology
1 publication, 5%
BBA Advances
BBA Advances, 1, 5%
BBA Advances
1 publication, 5%
Pharmacological Research
Pharmacological Research, 1, 5%
Pharmacological Research
1 publication, 5%
Alzheimer's and Dementia
Alzheimer's and Dementia, 1, 5%
Alzheimer's and Dementia
1 publication, 5%
Phytotherapy Research
Phytotherapy Research, 1, 5%
Phytotherapy Research
1 publication, 5%
Biotechnic and Histochemistry
Biotechnic and Histochemistry, 1, 5%
Biotechnic and Histochemistry
1 publication, 5%
Cancer Investigation
Cancer Investigation, 1, 5%
Cancer Investigation
1 publication, 5%
Journal of Neuroscience
Journal of Neuroscience, 1, 5%
Journal of Neuroscience
1 publication, 5%
Biomedicine and Pharmacotherapy
Biomedicine and Pharmacotherapy, 1, 5%
Biomedicine and Pharmacotherapy
1 publication, 5%
Cancer Reports
Cancer Reports, 1, 5%
Cancer Reports
1 publication, 5%
1
2

Citations by publishers

1
2
3
Elsevier
Elsevier, 3, 15%
Elsevier
3 publications, 15%
Wiley
Wiley, 3, 15%
Wiley
3 publications, 15%
Bentham Science
Bentham Science, 2, 10%
Bentham Science
2 publications, 10%
Springer Nature
Springer Nature, 2, 10%
Springer Nature
2 publications, 10%
Taylor & Francis
Taylor & Francis, 2, 10%
Taylor & Francis
2 publications, 10%
Wolters Kluwer Health
Wolters Kluwer Health, 2, 10%
Wolters Kluwer Health
2 publications, 10%
Oxford University Press
Oxford University Press, 1, 5%
Oxford University Press
1 publication, 5%
Mary Ann Liebert
Mary Ann Liebert, 1, 5%
Mary Ann Liebert
1 publication, 5%
Frontiers Media S.A.
Frontiers Media S.A., 1, 5%
Frontiers Media S.A.
1 publication, 5%
Society for Neuroscience
Society for Neuroscience, 1, 5%
Society for Neuroscience
1 publication, 5%
1
2
3
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Saretzki G., Miwa S. Telomerase and mTOR in the brain: the mitochondria connection // Neural Regeneration Research. 2017. Vol. 12. No. 3. p. 358.
GOST all authors (up to 50) Copy
Saretzki G., Miwa S. Telomerase and mTOR in the brain: the mitochondria connection // Neural Regeneration Research. 2017. Vol. 12. No. 3. p. 358.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.4103/1673-5374.202922
UR - https://doi.org/10.4103%2F1673-5374.202922
TI - Telomerase and mTOR in the brain: the mitochondria connection
T2 - Neural Regeneration Research
AU - Saretzki, G
AU - Miwa, S
PY - 2017
DA - 2017/03/24 00:00:00
PB - Wolters Kluwer Health
SP - 358
IS - 3
VL - 12
PMID - 28469639
SN - 1673-5374
SN - 1876-7958
ER -
BibTex
Cite this
BibTex Copy
@article{2017
author = {G Saretzki and S Miwa},
title = {Telomerase and mTOR in the brain: the mitochondria connection},
journal = {Neural Regeneration Research},
year = {2017},
volume = {12},
publisher = {Wolters Kluwer Health},
month = {mar},
url = {https://doi.org/10.4103%2F1673-5374.202922},
number = {3},
pages = {358},
doi = {10.4103/1673-5374.202922}
}
Found error?