Open Access
Autophagy, volume 8, issue 12, pages 1877-1881
Macroautophagy-aided elimination of chromatin
Publication type: Journal Article
Publication date: 2012-12-01
PubMed ID:
22935563
Molecular Biology
Cell Biology
Abstract
How tumor cells process damaged or unwanted DNA is a matter of much interest. Recently, Rello-Varona et al. (Cell Cycle 2012; 11:170–76) reported the involvement of macroautophagy (hereon autophagy) in the elimination of micronuclei (MN) from osteosarcoma cells. Prior to that, diminution of whole nuclei from multinucleated TP53-mutant tumor cells was described. Here, we discuss these two kinds of chromatin autophagy evoked after genotoxic stress in the context of the various biological processes involved: (1) endopolyploidy and the ploidy cycle; (2) the timing of DNA synthesis; (3) DNA repair; (4) chromatin:nuclear envelope interactions; and (5) cytoplasmic autophagy. We suggest that whereas some MN can be reunited with the main nucleus (through interactions with envelope-limited chromatin sheets) and participate in DNA repair, failure of repair serves as a signal for the chromatin autophagy of MN. In turn, autophagy of whole sub-nuclei in multi-nucleated cells appears to favor de-polyploidization, mitigation of aneuploidy with its adverse effects, thereby promoting the survival fitness of descendents and treatment resistance. Thus, both kinds of chromatin autophagy provide tumor cells with the opportunity to repair DNA, sort and resort chromatin, reduce DNA content, and enhance survival.
Citations by journals
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International Journal of Molecular Sciences
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1 publication, 3.23%
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1 publication, 3.23%
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1 publication, 3.23%
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Problemy Radiatsiinoi Medytsyny ta Radiobiolohii
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Problemy Radiatsiinoi Medytsyny ta Radiobiolohii, 1, 3.23%
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1 publication, 3.23%
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Journal of Cell Biology
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1 publication, 3.23%
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3
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Citations by publishers
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Taylor & Francis
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Taylor & Francis
5 publications, 16.13%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Elsevier
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3 publications, 9.68%
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1 publication, 3.23%
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Springer Nature
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Springer Nature
1 publication, 3.23%
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Public Library of Science (PLoS)
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1 publication, 3.23%
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Microbiology Research Foundation
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Microbiology Research Foundation, 1, 3.23%
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1 publication, 3.23%
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Oxford University Press
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Oxford University Press
1 publication, 3.23%
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Naukovyi tsentr radiatsiinoi medytsyny AMN Ukrainy
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Naukovyi tsentr radiatsiinoi medytsyny AMN Ukrainy, 1, 3.23%
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1 publication, 3.23%
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Rockefeller University Press
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Rockefeller University Press
1 publication, 3.23%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Erenpreisa J. et al. Macroautophagy-aided elimination of chromatin // Autophagy. 2012. Vol. 8. No. 12. pp. 1877-1881.
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Erenpreisa J., Huna A., Salmina K., Jackson T. R., Cragg M. S. Macroautophagy-aided elimination of chromatin // Autophagy. 2012. Vol. 8. No. 12. pp. 1877-1881.
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TY - JOUR
DO - 10.4161/auto.21610
UR - https://doi.org/10.4161%2Fauto.21610
TI - Macroautophagy-aided elimination of chromatin
T2 - Autophagy
AU - Erenpreisa, Jekaterina
AU - Huna, Anda
AU - Salmina, Kristine
AU - Jackson, Thomas R
AU - Cragg, Mark S.
PY - 2012
DA - 2012/12/01 00:00:00
PB - Taylor & Francis
SP - 1877-1881
IS - 12
VL - 8
PMID - 22935563
SN - 1554-8627
ER -
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@article{2012_Erenpreisa,
author = {Jekaterina Erenpreisa and Anda Huna and Kristine Salmina and Thomas R Jackson and Mark S. Cragg},
title = {Macroautophagy-aided elimination of chromatin},
journal = {Autophagy},
year = {2012},
volume = {8},
publisher = {Taylor & Francis},
month = {dec},
url = {https://doi.org/10.4161%2Fauto.21610},
number = {12},
pages = {1877--1881},
doi = {10.4161/auto.21610}
}
Cite this
MLA
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Erenpreisa, Jekaterina, et al. “Macroautophagy-aided elimination of chromatin.” Autophagy, vol. 8, no. 12, Dec. 2012, pp. 1877-1881. https://doi.org/10.4161%2Fauto.21610.