Open Access

Theranostics, volume 8, issue 19, pages 5259-5275

Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development

Jo Yeonho ¹

Choi N W ²

Kim Kyobum ³

Koo Hyung-Jun ⁴

Choi Jonghoon ¹

Kim H S ^{5, 6}

Hide authors affiliations Show authors affiliations: 6 affiliations

School of Integrative Engineering Chung‐Ang University Seoul 06974 Republic of Korea |

Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea |

Division of Bioengineering Incheon National University Incheon Republic of Korea |

⁴

Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul, Republic of Korea |

⁵

Center for BioMicrosystems Brain Science Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea |

⁶

Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea |

Publication type: Journal Article

Publication date: 2018-11-04

Ivyspring International Publisher

Journal: Theranostics

Quartile SCImago

Quartile WOS

Impact factor: 12.4

ISSN: 18387640

DOI: 10.7150/thno.29098

Copy DOI

PubMed ID: 30555545

Medicine (miscellaneous)

Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Abstract

For decades, scientists have been using two-dimensional cell culture platforms for high-throughput drug screening of anticancer drugs. Growing evidence indicates that the results of anti-cancer drug screening vary with the cell culture microenvironment, and this variation has been proposed as a reason for the high failure rate of clinical trials. Since the culture condition-dependent drug sensitivity of anti-cancer drugs may negatively impact the identification of clinically effective drug candidates, more reliable in vitro cancer platforms are urgently needed. In this review article, we provide an overview of how cell culture conditions can alter drug efficacy and highlight the importance of developing more reliable cancer drug testing platforms for use in the drug discovery process. The environmental factors that can alter drug delivery and efficacy are reviewed. Based on these observations of chemoresistant tumor physiology, we summarize the recent advances in the fabrication of in vitro cancer models and the model-dependent cytotoxicity of anti-cancer drugs, with a particular focus on engineered environmental factors in these platforms. It is believed that more physiologically relevant cancer models can revolutionize the drug discovery process.

By date By citations

Citations by journals

	1 2 3 4 5 6
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 6, 4.96% International Journal of Molecular Sciences 6 publications, 4.96%
Pharmaceutics	Pharmaceutics, 5, 4.13% Pharmaceutics 5 publications, 4.13%
Frontiers in Pharmacology	Frontiers in Pharmacology, 2, 1.65% Frontiers in Pharmacology 2 publications, 1.65%
Micromachines	Micromachines, 2, 1.65% Micromachines 2 publications, 1.65%
Nanomaterials	Nanomaterials, 2, 1.65% Nanomaterials 2 publications, 1.65%
Frontiers in Oncology	Frontiers in Oncology, 2, 1.65% Frontiers in Oncology 2 publications, 1.65%
Scientific Reports	Scientific Reports, 2, 1.65% Scientific Reports 2 publications, 1.65%
Drug Delivery and Translational Research	Drug Delivery and Translational Research, 2, 1.65% Drug Delivery and Translational Research 2 publications, 1.65%
Biochimica et Biophysica Acta - Reviews on Cancer	Biochimica et Biophysica Acta - Reviews on Cancer, 2, 1.65% Biochimica et Biophysica Acta - Reviews on Cancer 2 publications, 1.65%
TrAC - Trends in Analytical Chemistry	TrAC - Trends in Analytical Chemistry, 2, 1.65% TrAC - Trends in Analytical Chemistry 2 publications, 1.65%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 2, 1.65% International Journal of Pharmaceutics 2 publications, 1.65%
Mitochondrion	Mitochondrion, 2, 1.65% Mitochondrion 2 publications, 1.65%
Cancer Reports	Cancer Reports, 2, 1.65% Cancer Reports 2 publications, 1.65%
The Analyst	The Analyst, 2, 1.65% The Analyst 2 publications, 1.65%
Journal of Cancer Research and Clinical Oncology	Journal of Cancer Research and Clinical Oncology, 1, 0.83% Journal of Cancer Research and Clinical Oncology 1 publication, 0.83%
Biomicrofluidics	Biomicrofluidics, 1, 0.83% Biomicrofluidics 1 publication, 0.83%
Journal of Biomaterials and Tissue Engineering	Journal of Biomaterials and Tissue Engineering, 1, 0.83% Journal of Biomaterials and Tissue Engineering 1 publication, 0.83%
Oncotarget	Oncotarget, 1, 0.83% Oncotarget 1 publication, 0.83%
PeerJ	PeerJ, 1, 0.83% PeerJ 1 publication, 0.83%
Integrative Cancer Therapies	Integrative Cancer Therapies, 1, 0.83% Integrative Cancer Therapies 1 publication, 0.83%
Technology in Cancer Research and Treatment	Technology in Cancer Research and Treatment, 1, 0.83% Technology in Cancer Research and Treatment 1 publication, 0.83%
Cancers	Cancers, 1, 0.83% Cancers 1 publication, 0.83%
Genes	Genes, 1, 0.83% Genes 1 publication, 0.83%
Marine Drugs	Marine Drugs, 1, 0.83% Marine Drugs 1 publication, 0.83%
Biomedicines	Biomedicines, 1, 0.83% Biomedicines 1 publication, 0.83%
Molecules	Molecules, 1, 0.83% Molecules 1 publication, 0.83%
Polymers	Polymers, 1, 0.83% Polymers 1 publication, 0.83%
Organoids	Organoids, 1, 0.83% Organoids 1 publication, 0.83%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 1, 0.83% Frontiers in Bioengineering and Biotechnology 1 publication, 0.83%
	1 2 3 4 5 6

Citations by publishers

	5 10 15 20 25 30
Elsevier	Elsevier, 27, 22.31% Elsevier 27 publications, 22.31%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 25, 20.66% Multidisciplinary Digital Publishing Institute (MDPI) 25 publications, 20.66%
Springer Nature	Springer Nature, 17, 14.05% Springer Nature 17 publications, 14.05%
Frontiers Media S.A.	Frontiers Media S.A., 6, 4.96% Frontiers Media S.A. 6 publications, 4.96%
Wiley	Wiley, 6, 4.96% Wiley 6 publications, 4.96%
American Chemical Society (ACS)	American Chemical Society (ACS), 5, 4.13% American Chemical Society (ACS) 5 publications, 4.13%
Taylor & Francis	Taylor & Francis, 4, 3.31% Taylor & Francis 4 publications, 3.31%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 2.48% Royal Society of Chemistry (RSC) 3 publications, 2.48%
SAGE	SAGE, 2, 1.65% SAGE 2 publications, 1.65%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 0.83% American Institute of Physics (AIP) 1 publication, 0.83%
American Scientific Publishers	American Scientific Publishers, 1, 0.83% American Scientific Publishers 1 publication, 0.83%
Impact Journals	Impact Journals, 1, 0.83% Impact Journals 1 publication, 0.83%
PeerJ	PeerJ, 1, 0.83% PeerJ 1 publication, 0.83%
Mary Ann Liebert	Mary Ann Liebert, 1, 0.83% Mary Ann Liebert 1 publication, 0.83%
Korean Society for Biotechnology and Bioengineering	Korean Society for Biotechnology and Bioengineering, 1, 0.83% Korean Society for Biotechnology and Bioengineering 1 publication, 0.83%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.83% Public Library of Science (PLoS) 1 publication, 0.83%
Neoplasia Press	Neoplasia Press, 1, 0.83% Neoplasia Press 1 publication, 0.83%
Korean Society of Industrial Engineering Chemistry	Korean Society of Industrial Engineering Chemistry, 1, 0.83% Korean Society of Industrial Engineering Chemistry 1 publication, 0.83%
Thieme	Thieme, 1, 0.83% Thieme 1 publication, 0.83%
Hindawi Limited	Hindawi Limited, 1, 0.83% Hindawi Limited 1 publication, 0.83%
Pleiades Publishing	Pleiades Publishing, 1, 0.83% Pleiades Publishing 1 publication, 0.83%
Asian Journal of Chemistry	Asian Journal of Chemistry, 1, 0.83% Asian Journal of Chemistry 1 publication, 0.83%
AME Publishing Company	AME Publishing Company, 1, 0.83% AME Publishing Company 1 publication, 0.83%
Spandidos Publications	Spandidos Publications, 1, 0.83% Spandidos Publications 1 publication, 0.83%
IOP Publishing	IOP Publishing, 1, 0.83% IOP Publishing 1 publication, 0.83%
	5 10 15 20 25 30

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Jo Y. et al. Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development // Theranostics. 2018. Vol. 8. No. 19. pp. 5259-5275.

GOST all authors (up to 50) Copy

Jo Y., Choi N. W., Kim K., Koo H., Choi J., Kim H. S. Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development // Theranostics. 2018. Vol. 8. No. 19. pp. 5259-5275.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.7150/thno.29098

UR - https://doi.org/10.7150%2Fthno.29098

TI - Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development

T2 - Theranostics

AU - Jo, Yeonho

AU - Choi, N W

AU - Kim, Kyobum

AU - Koo, Hyung-Jun

AU - Choi, Jonghoon

AU - Kim, H S

PY - 2018

DA - 2018/11/04 00:00:00

PB - Ivyspring International Publisher

SP - 5259-5275

IS - 19

VL - 8

PMID - 30555545

SN - 1838-7640

ER -

BibTex |

Cite this

BibTex Copy

@article{2018_Jo,

author = {Yeonho Jo and N W Choi and Kyobum Kim and Hyung-Jun Koo and Jonghoon Choi and H S Kim},

title = {Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development},

journal = {Theranostics},

year = {2018},

volume = {8},

publisher = {Ivyspring International Publisher},

month = {nov},

url = {https://doi.org/10.7150%2Fthno.29098},

number = {19},

pages = {5259--5275},

doi = {10.7150/thno.29098}

}

MLA

Cite this

MLA Copy

Jo, Yeonho, et al. “Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development.” Theranostics, vol. 8, no. 19, Nov. 2018, pp. 5259-5275. https://doi.org/10.7150%2Fthno.29098.

Found error?

Publisher

Ivyspring International Publisher

Journal

Theranostics

Quartile SCImago

Quartile WOS

Impact factor

12.4

ISSN

18387640 (Print)

Profiles

Choi, Jonghoon H