Open Access
Open access
Theranostics, volume 9, issue 23, pages 6824-6839

PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery

Derks Yvonne H.W. 1
Löwik Dennis W. P. M. 2
Sedelaar J.P. Michiel 3
Gotthardt Martin 1
Boerman Otto C. 1
Rijpkema Mark 1
Lütje Susanne 4
Heskamp Sandra 1
Publication typeJournal Article
Publication date2019-09-23
Journal: Theranostics
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor12.4
ISSN18387640
PubMed ID:  31660071
Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Abstract
Despite recent improvements in imaging and therapy, prostate cancer (PCa) still causes substantial morbidity and mortality. In surgical treatment, incomplete resection of PCa and understaging of possible undetected metastases may lead to disease recurrence and consequently poor patient outcome. To increase the chance of accurate staging and subsequently complete removal of all cancerous tissue, prostate specific membrane antigen (PSMA) targeting agents may provide the surgeon an aid for the intraoperative detection and resection of PCa lesions. Two modalities suitable for this purpose are radionuclide detection, which allows sensitive intraoperative localization of tumor lesions with a gamma probe, and fluorescence imaging, allowing tumor visualization and delineation. Next to fluorescence, use of photosensitizers may enable intraoperative targeted photodynamic therapy to eradicate remaining tumor lesions. Since radiodetection and optical imaging techniques each have their own strengths and weaknesses, a combination of both modalities could be of additional value. Here, we provide an overview of recent preclinical and clinical advances in PSMA-targeted radio- and fluorescence-guided surgery of PCa.

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GOST Copy
Derks Y. H. et al. PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery // Theranostics. 2019. Vol. 9. No. 23. pp. 6824-6839.
GOST all authors (up to 50) Copy
Derks Y. H., Löwik D. W. P. M., Sedelaar J. M., Gotthardt M., Boerman O. C., Rijpkema M., Lütje S., Heskamp S. PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery // Theranostics. 2019. Vol. 9. No. 23. pp. 6824-6839.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.7150/thno.36739
UR - https://doi.org/10.7150%2Fthno.36739
TI - PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery
T2 - Theranostics
AU - Derks, Yvonne H.W.
AU - Löwik, Dennis W. P. M.
AU - Sedelaar, J.P. Michiel
AU - Gotthardt, Martin
AU - Boerman, Otto C.
AU - Rijpkema, Mark
AU - Lütje, Susanne
AU - Heskamp, Sandra
PY - 2019
DA - 2019/09/23 00:00:00
PB - Ivyspring International Publisher
SP - 6824-6839
IS - 23
VL - 9
PMID - 31660071
SN - 1838-7640
ER -
BibTex |
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BibTex Copy
@article{2019_Derks
author = {Yvonne H.W. Derks and Dennis W. P. M. Löwik and J.P. Michiel Sedelaar and Martin Gotthardt and Otto C. Boerman and Mark Rijpkema and Susanne Lütje and Sandra Heskamp},
title = {PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery},
journal = {Theranostics},
year = {2019},
volume = {9},
publisher = {Ivyspring International Publisher},
month = {sep},
url = {https://doi.org/10.7150%2Fthno.36739},
number = {23},
pages = {6824--6839},
doi = {10.7150/thno.36739}
}
MLA
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MLA Copy
Derks, Yvonne H.W., et al. “PSMA-targeting agents for radio- and fluorescence-guided prostate cancer surgery.” Theranostics, vol. 9, no. 23, Sep. 2019, pp. 6824-6839. https://doi.org/10.7150%2Fthno.36739.
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