Open Access
eLife, volume 4
Protein biogenesis machinery is a driver of replicative aging in yeast
Janssens Georges E.
1
,
Meinema Anne C.
2
,
Gonzalez Javier
3
,
Wolters Justina C.
4
,
Schmidt Alexander
5
,
Guryev Victor
1
,
Bischoff Rainer
4
,
Wit Ernst C.
3
,
Veenhoff Liesbeth M
1
,
Heinemann Matthias
2
1
European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
|
2
Molecular Systems Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands
|
3
Probability and Statistics, Johann Bernoulli Institute of Mathematics and Computer Science, University of Groningen, Groningen, The Netherlands
|
4
Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands
|
Publication type: Journal Article
Publication date: 2015-12-01
PubMed ID:
26422514
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Immunology and Microbiology
General Neuroscience
Abstract
An integrated account of the molecular changes occurring during the process of cellular aging is crucial towards understanding the underlying mechanisms. Here, using novel culturing and computational methods as well as latest analytical techniques, we mapped the proteome and transcriptome during the replicative lifespan of budding yeast. With age, we found primarily proteins involved in protein biogenesis to increase relative to their transcript levels. Exploiting the dynamic nature of our data, we reconstructed high-level directional networks, where we found the same protein biogenesis-related genes to have the strongest ability to predict the behavior of other genes in the system. We identified metabolic shifts and the loss of stoichiometry in protein complexes as being consequences of aging. We propose a model whereby the uncoupling of protein levels of biogenesis-related genes from their transcript levels is causal for the changes occurring in aging yeast. Our model explains why targeting protein synthesis, or repairing the downstream consequences, can serve as interventions in aging. DOI: http://dx.doi.org/10.7554/eLife.08527.001
Citations by journals
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eLife
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eLife
16 publications, 11.27%
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iScience
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iScience
4 publications, 2.82%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
3 publications, 2.11%
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Current Genetics
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Current Genetics
3 publications, 2.11%
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Cell
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Cell
3 publications, 2.11%
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Cell Reports
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Cell Reports
3 publications, 2.11%
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FEBS Journal
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FEBS Journal
3 publications, 2.11%
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
3 publications, 2.11%
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BMC Genomics
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BMC Genomics
2 publications, 1.41%
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Cells
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Cells
2 publications, 1.41%
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Frontiers in Genetics
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Frontiers in Genetics
2 publications, 1.41%
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Scientific Reports
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Scientific Reports
2 publications, 1.41%
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GeroScience
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GeroScience
2 publications, 1.41%
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Ageing Research Reviews
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Ageing Research Reviews
2 publications, 1.41%
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Translational Medicine of Aging
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Translational Medicine of Aging
2 publications, 1.41%
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Cell Systems
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Cell Systems
2 publications, 1.41%
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Experimental Cell Research
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Experimental Cell Research
2 publications, 1.41%
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Proteomics
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Proteomics
2 publications, 1.41%
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PLoS Biology
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PLoS Biology
2 publications, 1.41%
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Molecular Cell
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Molecular Cell
2 publications, 1.41%
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Aging
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Aging
1 publication, 0.7%
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Biochemical Society Transactions
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Biochemical Society Transactions
1 publication, 0.7%
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Metabolites
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Metabolites
1 publication, 0.7%
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Genes
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Genes
1 publication, 0.7%
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Journal of Fungi
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Journal of Fungi
1 publication, 0.7%
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Genome Medicine
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Genome Medicine
1 publication, 0.7%
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npj Aging and Mechanisms of Disease
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npj Aging and Mechanisms of Disease
1 publication, 0.7%
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Communications Biology
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Communications Biology
1 publication, 0.7%
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Biogerontology
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Biogerontology
1 publication, 0.7%
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2
4
6
8
10
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14
16
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Citations by publishers
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5
10
15
20
25
30
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Elsevier
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Elsevier
30 publications, 21.13%
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Springer Nature
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Springer Nature
16 publications, 11.27%
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eLife Sciences Publications
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eLife Sciences Publications
16 publications, 11.27%
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Wiley
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Wiley
10 publications, 7.04%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
8 publications, 5.63%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
3 publications, 2.11%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
3 publications, 2.11%
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Frontiers Media S.A.
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Frontiers Media S.A.
2 publications, 1.41%
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KeAi Communications Co.
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KeAi Communications Co.
2 publications, 1.41%
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EMBO press
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EMBO press
2 publications, 1.41%
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Oxford University Press
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Oxford University Press
2 publications, 1.41%
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Impact Journals
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Impact Journals
1 publication, 0.7%
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Portland Press
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Portland Press
1 publication, 0.7%
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Genetics Society of America
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Genetics Society of America
1 publication, 0.7%
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Cold Spring Harbor Laboratory
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Cold Spring Harbor Laboratory
1 publication, 0.7%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 0.7%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Janssens G. E. et al. Protein biogenesis machinery is a driver of replicative aging in yeast // eLife. 2015. Vol. 4.
GOST all authors (up to 50)
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Janssens G. E., Meinema A. C., Gonzalez J., Wolters J. C., Schmidt A., Guryev V., Bischoff R., Wit E. C., Veenhoff L. M., Heinemann M. Protein biogenesis machinery is a driver of replicative aging in yeast // eLife. 2015. Vol. 4.
Cite this
RIS
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TY - JOUR
DO - 10.7554/eLife.08527
UR - https://doi.org/10.7554%2FeLife.08527
TI - Protein biogenesis machinery is a driver of replicative aging in yeast
T2 - eLife
AU - Janssens, Georges E.
AU - Meinema, Anne C.
AU - Gonzalez, Javier
AU - Wolters, Justina C.
AU - Schmidt, Alexander
AU - Guryev, Victor
AU - Bischoff, Rainer
AU - Wit, Ernst C.
AU - Veenhoff, Liesbeth M
AU - Heinemann, Matthias
PY - 2015
DA - 2015/12/01 00:00:00
PB - eLife Sciences Publications
VL - 4
PMID - 26422514
SN - 2050-084X
ER -
Cite this
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@article{2015_Janssens,
author = {Georges E. Janssens and Anne C. Meinema and Javier Gonzalez and Justina C. Wolters and Alexander Schmidt and Victor Guryev and Rainer Bischoff and Ernst C. Wit and Liesbeth M Veenhoff and Matthias Heinemann},
title = {Protein biogenesis machinery is a driver of replicative aging in yeast},
journal = {eLife},
year = {2015},
volume = {4},
publisher = {eLife Sciences Publications},
month = {dec},
url = {https://doi.org/10.7554%2FeLife.08527},
doi = {10.7554/eLife.08527}
}