Open Access
eLife, volume 7
Intrinsic cooperativity potentiates parallel cis-regulatory evolution
Sorrells Trevor R
1, 2
,
Johnson Amanda N
3
,
Howard Conor William
1, 2
,
Britton Candace S
1, 2
,
Fowler Kyle R
1, 2
,
Feigerle Jordan T
3
,
Weil P. Anthony
3
,
Johnson Alexander D
1, 2
1
Department of Biochemistry and Biophysics, Tetrad Graduate Program, University of California, San Francisco, United States
|
2
Department of Microbiology and Immunology, University of California, San Francisco, United States
|
3
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee
|
Publication type: Journal Article
Publication date: 2018-09-10
PubMed ID:
30198843
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Immunology and Microbiology
General Neuroscience
Abstract
Convergent evolutionary events in independent lineages provide an opportunity to understand why evolution favors certain outcomes over others. We studied such a case where a large set of genes—those coding for the ribosomal proteins—gained cis-regulatory sequences for a particular transcription regulator (Mcm1) in independent fungal lineages. We present evidence that these gains occurred because Mcm1 shares a mechanism of transcriptional activation with an ancestral regulator of the ribosomal protein genes, Rap1. Specifically, we show that Mcm1 and Rap1 have the inherent ability to cooperatively activate transcription through contacts with the general transcription factor TFIID. Because the two regulatory proteins share a common interaction partner, the presence of one ancestral cis-regulatory sequence can ‘channel’ random mutations into functional sites for the second regulator. At a genomic scale, this type of intrinsic cooperativity can account for a pattern of parallel evolution involving the fixation of hundreds of substitutions.
Citations by journals
1
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Scientific Reports
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Scientific Reports
1 publication, 5.56%
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Frontiers in Ecology and Evolution
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Trends in Plant Science
1 publication, 5.56%
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Current Biology
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1 publication, 5.56%
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G3: Genes, Genomes, Genetics
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1 publication, 5.56%
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Molecular Biology and Evolution
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1 publication, 5.56%
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Cell Systems
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1 publication, 5.56%
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Cell
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Cell
1 publication, 5.56%
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eLife
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eLife
1 publication, 5.56%
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iScience
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iScience
1 publication, 5.56%
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Proceedings of the National Academy of Sciences of the United States of America
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Proceedings of the National Academy of Sciences of the United States of America
1 publication, 5.56%
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Genetics
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Genetics
1 publication, 5.56%
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1
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Citations by publishers
1
2
3
4
5
6
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Elsevier
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Elsevier
6 publications, 33.33%
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Genetics Society of America
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Genetics Society of America
2 publications, 11.11%
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Springer Nature
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Springer Nature
1 publication, 5.56%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 5.56%
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Oxford University Press
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Oxford University Press
1 publication, 5.56%
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eLife Sciences Publications
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eLife Sciences Publications
1 publication, 5.56%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
1 publication, 5.56%
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1
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3
4
5
6
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sorrells T. R. et al. Intrinsic cooperativity potentiates parallel cis-regulatory evolution // eLife. 2018. Vol. 7.
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Sorrells T. R., Johnson A. N., Howard C. W., Britton C. S., Fowler K. R., Feigerle J. T., Weil P. A., Johnson A. D. Intrinsic cooperativity potentiates parallel cis-regulatory evolution // eLife. 2018. Vol. 7.
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TY - JOUR
DO - 10.7554/eLife.37563
UR - https://doi.org/10.7554%2FeLife.37563
TI - Intrinsic cooperativity potentiates parallel cis-regulatory evolution
T2 - eLife
AU - Sorrells, Trevor R
AU - Johnson, Amanda N
AU - Howard, Conor William
AU - Britton, Candace S
AU - Fowler, Kyle R
AU - Feigerle, Jordan T
AU - Weil, P. Anthony
AU - Johnson, Alexander D
PY - 2018
DA - 2018/09/10 00:00:00
PB - eLife Sciences Publications
VL - 7
PMID - 30198843
SN - 2050-084X
ER -
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@article{2018_Sorrells
author = {Trevor R Sorrells and Amanda N Johnson and Conor William Howard and Candace S Britton and Kyle R Fowler and Jordan T Feigerle and P. Anthony Weil and Alexander D Johnson},
title = {Intrinsic cooperativity potentiates parallel cis-regulatory evolution},
journal = {eLife},
year = {2018},
volume = {7},
publisher = {eLife Sciences Publications},
month = {sep},
url = {https://doi.org/10.7554%2FeLife.37563},
doi = {10.7554/eLife.37563}
}