Open Access
Open access
eLife, volume 7

Intrinsic cooperativity potentiates parallel cis-regulatory evolution

Sorrells Trevor R 1, 2
Johnson Amanda N 3
Howard Conor William 1, 2
Britton Candace S 1, 2
Fowler Kyle R 1, 2
Feigerle Jordan T 3
Weil P. Anthony 3
Johnson Alexander D 1, 2
1
 
Department of Biochemistry and Biophysics, Tetrad Graduate Program, University of California, San Francisco, United States
2
 
Department of Microbiology and Immunology, University of California, San Francisco, United States
3
 
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee
Publication typeJournal Article
Publication date2018-09-10
Journal: eLife
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor7.7
ISSN2050084X
PubMed ID:  30198843
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Immunology and Microbiology
General Neuroscience
Abstract
Convergent evolutionary events in independent lineages provide an opportunity to understand why evolution favors certain outcomes over others. We studied such a case where a large set of genes—those coding for the ribosomal proteins—gained cis-regulatory sequences for a particular transcription regulator (Mcm1) in independent fungal lineages. We present evidence that these gains occurred because Mcm1 shares a mechanism of transcriptional activation with an ancestral regulator of the ribosomal protein genes, Rap1. Specifically, we show that Mcm1 and Rap1 have the inherent ability to cooperatively activate transcription through contacts with the general transcription factor TFIID. Because the two regulatory proteins share a common interaction partner, the presence of one ancestral cis-regulatory sequence can ‘channel’ random mutations into functional sites for the second regulator. At a genomic scale, this type of intrinsic cooperativity can account for a pattern of parallel evolution involving the fixation of hundreds of substitutions.

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GOST Copy
Sorrells T. R. et al. Intrinsic cooperativity potentiates parallel cis-regulatory evolution // eLife. 2018. Vol. 7.
GOST all authors (up to 50) Copy
Sorrells T. R., Johnson A. N., Howard C. W., Britton C. S., Fowler K. R., Feigerle J. T., Weil P. A., Johnson A. D. Intrinsic cooperativity potentiates parallel cis-regulatory evolution // eLife. 2018. Vol. 7.
RIS |
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RIS Copy
TY - JOUR
DO - 10.7554/eLife.37563
UR - https://doi.org/10.7554%2FeLife.37563
TI - Intrinsic cooperativity potentiates parallel cis-regulatory evolution
T2 - eLife
AU - Sorrells, Trevor R
AU - Johnson, Amanda N
AU - Howard, Conor William
AU - Britton, Candace S
AU - Fowler, Kyle R
AU - Feigerle, Jordan T
AU - Weil, P. Anthony
AU - Johnson, Alexander D
PY - 2018
DA - 2018/09/10 00:00:00
PB - eLife Sciences Publications
VL - 7
PMID - 30198843
SN - 2050-084X
ER -
BibTex
Cite this
BibTex Copy
@article{2018_Sorrells
author = {Trevor R Sorrells and Amanda N Johnson and Conor William Howard and Candace S Britton and Kyle R Fowler and Jordan T Feigerle and P. Anthony Weil and Alexander D Johnson},
title = {Intrinsic cooperativity potentiates parallel cis-regulatory evolution},
journal = {eLife},
year = {2018},
volume = {7},
publisher = {eLife Sciences Publications},
month = {sep},
url = {https://doi.org/10.7554%2FeLife.37563},
doi = {10.7554/eLife.37563}
}
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