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eLife, том 11

Telomere length regulation by Rif1 protein from Hansenula polymorpha

Тип документаJournal Article
Дата публикации2022-02-07
ИздательeLife Sciences Publications
Название журналаeLife
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 20218.71
ISSN2050084X
General Biochemistry, Genetics and Molecular Biology
General Medicine
General Immunology and Microbiology
General Neuroscience
Краткое описание
Rif1 is a large multifaceted protein involved in various processes of DNA metabolism – from telomere length regulation and replication to double-strand break repair. The mechanistic details of its action, however, are often poorly understood. Here, we report functional characterization of the Rif1 homologue from methylotrophic thermotolerant budding yeast Hansenula polymorpha DL-1. We show that, similar to other yeast species, H. polymorpha Rif1 suppresses telomerase-dependent telomere elongation. We uncover two novel modes of Rif1 recruitment at H. polymorpha telomeres: via direct DNA binding and through the association with the Ku heterodimer. Both of these modes (at least partially) require the intrinsically disordered N-terminal extension – a region of the protein present exclusively in yeast species. We also demonstrate that Rif1 binds Stn1 and promotes its accumulation at telomeres in H. polymorpha.
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ГОСТ |
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1. Malyavko A. N. и др. Telomere length regulation by Rif1 protein from Hansenula polymorpha // eLife. 2022. Т. 11.
RIS |
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TY - JOUR

DO - 10.7554/elife.75010

UR - http://dx.doi.org/10.7554/eLife.75010

TI - Telomere length regulation by Rif1 protein from Hansenula polymorpha

T2 - eLife

AU - Malyavko, Alexander N

AU - Petrova, Olga A

AU - Zvereva, Maria I

AU - Polshakov, Vladimir I

AU - Dontsova, Olga A

PY - 2022

DA - 2022/02/07

PB - eLife Sciences Publications, Ltd

VL - 11

SN - 2050-084X

ER -

BibTex |
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@article{Malyavko_2022,

doi = {10.7554/elife.75010},

url = {https://doi.org/10.7554%2Felife.75010},

year = 2022,

month = {feb},

publisher = {{eLife} Sciences Publications, Ltd},

volume = {11},

author = {Alexander N Malyavko and Olga A Petrova and Maria I Zvereva and Vladimir I Polshakov and Olga A Dontsova},

title = {Telomere length regulation by Rif1 protein from Hansenula polymorpha},

journal = {{eLife}}

}

MLA
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Malyavko, Alexander N., et al. “Telomere Length Regulation by Rif1 Protein from Hansenula Polymorpha.” ELife, vol. 11, Feb. 2022. CLOCKSS, Crossref, https://doi.org/10.7554/elife.75010.