Journal of Surface Investigation, volume 12, issue 4, pages 717-726
Investigation of the Morphology and Structure of Porous Hybrid 3D Scaffolds Based on Polycaprolactone Involving Silicate-Containing Hydroxyapatite
Gorodzha S N
1
,
Surmeneva M A
1
,
Selezneva I I
2
,
Ermakov A M
2
,
Zaitsev V. V.
3
,
Surmenev R A
1
Publication type: Journal Article
Publication date: 2018-07-01
Journal:
Journal of Surface Investigation
Quartile SCImago
Q3
Quartile WOS
—
Impact factor: 0.3
ISSN: 10274510, 18197094
Surfaces, Coatings and Films
Abstract
The results of studies into microporous scaffolds based on polycaprolactone, in particular, involving nanoparticles and microparticles of modified (silicon-containing) hydroxyapatite (hybrid scaffolds) are presented. When hydroxyapatite particles are used during the electrospinning of polymer scaffolds, their porosity is found to increase substantially and a structure with nanofibers and microfibers can be created. X-ray phase analysis demonstrates that the characteristic lines of polycaprolactone and hydroxyapatite exist in the 3D hybrid scaffold structure. According to the data of infrared (IR) spectroscopy of the hydroxyapatitepowder precursor, (SiO4)4– ions are embedded in its lattice. The results of studies into the surface wettability indicate that the contact angles of wetting with water are smaller for hybrid scaffolds than for pure polycaprolactone scaffolds. Adhesive and proliferative activity tests of human mesenchymal stem cells (MSCs) performed upon hybrid-scaffold cultivation on the surface, as well as histologic investigations, indicate the high biocompatibility of the samples. On the basis of a polymerase chain reaction, it is revealed that the differentiation of MSCs occurs in the osteogenic direction. On account of a porous structure, hybrid scaffolds can be employed to recover bone-tissue defects.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Gorodzha S. N. et al. Investigation of the Morphology and Structure of Porous Hybrid 3D Scaffolds Based on Polycaprolactone Involving Silicate-Containing Hydroxyapatite // Journal of Surface Investigation. 2018. Vol. 12. No. 4. pp. 717-726.
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Gorodzha S. N., Surmeneva M. A., Selezneva I. I., Ermakov A. M., Zaitsev V. V., Surmenev R. A. Investigation of the Morphology and Structure of Porous Hybrid 3D Scaffolds Based on Polycaprolactone Involving Silicate-Containing Hydroxyapatite // Journal of Surface Investigation. 2018. Vol. 12. No. 4. pp. 717-726.
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TY - JOUR
DO - 10.1134/S1027451018040092
UR - https://doi.org/10.1134%2FS1027451018040092
TI - Investigation of the Morphology and Structure of Porous Hybrid 3D Scaffolds Based on Polycaprolactone Involving Silicate-Containing Hydroxyapatite
T2 - Journal of Surface Investigation
AU - Gorodzha, S N
AU - Surmeneva, M A
AU - Selezneva, I I
AU - Ermakov, A M
AU - Zaitsev, V. V.
AU - Surmenev, R A
PY - 2018
DA - 2018/07/01 00:00:00
PB - Pleiades Publishing
SP - 717-726
IS - 4
VL - 12
SN - 1027-4510
SN - 1819-7094
ER -
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@article{2018_Gorodzha,
author = {S N Gorodzha and M A Surmeneva and I I Selezneva and A M Ermakov and V. V. Zaitsev and R A Surmenev},
title = {Investigation of the Morphology and Structure of Porous Hybrid 3D Scaffolds Based on Polycaprolactone Involving Silicate-Containing Hydroxyapatite},
journal = {Journal of Surface Investigation},
year = {2018},
volume = {12},
publisher = {Pleiades Publishing},
month = {jul},
url = {https://doi.org/10.1134%2FS1027451018040092},
number = {4},
pages = {717--726},
doi = {10.1134/S1027451018040092}
}
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Gorodzha, S. N., et al. “Investigation of the Morphology and Structure of Porous Hybrid 3D Scaffolds Based on Polycaprolactone Involving Silicate-Containing Hydroxyapatite.” Journal of Surface Investigation, vol. 12, no. 4, Jul. 2018, pp. 717-726. https://doi.org/10.1134%2FS1027451018040092.
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