Biochemistry (Moscow), volume 82, issue 9, pages 1006-1016

Effect of anesthetics on efficiency of remote ischemic preconditioning

Publication typeJournal Article
Publication date2017-09-13
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor2.8
ISSN00062979, 16083040
Biochemistry
General Medicine
Abstract
Remote ischemic preconditioning of hind limbs (RIPC) is an effective method for preventing brain injury resulting from ischemia. However, in numerous studies RIPC has been used on the background of administered anesthetics, which also could exhibit neuroprotective properties. Therefore, investigation of the signaling pathways triggered by RIPC and the effect of anesthetics is important. In this study, we explored the effect of anesthetics (chloral hydrate and Zoletil) on the ability of RIPC to protect the brain from injury caused by ischemia and reperfusion. We found that RIPC without anesthesia resulted in statistically significant decrease in neurological deficit 24 h after ischemia, but did not affect the volume of brain injury. Administration of chloral hydrate or Zoletil one day prior to brain ischemia produced a preconditioning effect by their own, decreasing the degree of neurological deficit and lowering the volume of infarct with the use of Zoletil. The protective effects observed after RIPC with chloral hydrate or Zoletil were similar to those observed when only the respective anesthetic was used. RIPC was accompanied by significant increase in the level of brain proteins associated with the induction of ischemic tolerance such as pGSK-3β, BDNF, and HSP70. However, Zoletil did not affect the level of these proteins 24 h after injection, and chloral hydrate caused increase of only pGSK-3β. We conclude that RIPC, chloral hydrate, and Zoletil produce a significant neuroprotective effect, but the simultaneous use of anesthetics with RIPC does not enhance the degree of neuroprotection.

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Silachev D. et al. Effect of anesthetics on efficiency of remote ischemic preconditioning // Biochemistry (Moscow). 2017. Vol. 82. No. 9. pp. 1006-1016.
GOST all authors (up to 50) Copy
Silachev D., Usatikova E. A., Pevzner I. B., Zorova L. D., Babenko V. A., Gulyaev M. V., Pirogov Yu. A., Plotnikov E. Yu., Zorov D. B. Effect of anesthetics on efficiency of remote ischemic preconditioning // Biochemistry (Moscow). 2017. Vol. 82. No. 9. pp. 1006-1016.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1134/S0006297917090036
UR - https://doi.org/10.1134%2FS0006297917090036
TI - Effect of anesthetics on efficiency of remote ischemic preconditioning
T2 - Biochemistry (Moscow)
AU - Silachev, D.N.
AU - Usatikova, E A
AU - Pevzner, I B
AU - Zorova, L D
AU - Babenko, V. A.
AU - Gulyaev, M V
AU - Pirogov, Yu A
AU - Plotnikov, E Yu
AU - Zorov, D B
PY - 2017
DA - 2017/09/13 00:00:00
PB - Pleiades Publishing
SP - 1006-1016
IS - 9
VL - 82
SN - 0006-2979
SN - 1608-3040
ER -
BibTex |
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BibTex Copy
@article{2017_Silachev
author = {D.N. Silachev and E A Usatikova and I B Pevzner and L D Zorova and V. A. Babenko and M V Gulyaev and Yu A Pirogov and E Yu Plotnikov and D B Zorov},
title = {Effect of anesthetics on efficiency of remote ischemic preconditioning},
journal = {Biochemistry (Moscow)},
year = {2017},
volume = {82},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134%2FS0006297917090036},
number = {9},
pages = {1006--1016},
doi = {10.1134/S0006297917090036}
}
MLA
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MLA Copy
Silachev, D.N., et al. “Effect of anesthetics on efficiency of remote ischemic preconditioning.” Biochemistry (Moscow), vol. 82, no. 9, Sep. 2017, pp. 1006-1016. https://doi.org/10.1134%2FS0006297917090036.
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