Chemistry of Heterocyclic Compounds, volume 57, issue 4, pages 432-441
Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts
Vorozhtsov Nikolai O
1
,
Yarovaya Olga I.
2
,
Roznyatovskii Vitalii A
1
,
Tarasevich Boris N
1
,
Kozlovskaya Yuliya A
1
,
Petkova Aneliya I
1
,
Slita Aleksander V
3
,
Sinegubova Ekaterina O
3
,
Zarubaev Vladimir V.
3
,
Salakhutdinov Nariman F.
2
,
Publication type: Journal Article
Publication date: 2021-04-01
Journal:
Chemistry of Heterocyclic Compounds
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.5
ISSN: 00093122, 15738353
Organic Chemistry
Abstract
For the first time, convenient methods for the preparation of pyrazoline N-alkylidene salts based on terpene (camphor, camphorquinone, carvone) ketones, cage (adamantanone and norcamphor) ketones, and natural aldehydes (carvone and myrtenal) allowing the isolation of stable pyrazolinium salts in individual form were proposed. Optimization of the conditions for the synthesis of the target products was carried out. The antiviral activity of the synthesized salts was studied; among the tested compounds 1-bornylidene-3-phenylpyrazolinium tetrafluoroborate (IC50 6.2 μM, SI 107) exhibited the greatest activity against influenza A/Puerto Rico/8/34 (H1N1) virus.
Citations by journals
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Topics in Current Chemistry
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Topics in Current Chemistry
1 publication, 50%
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Molecules
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Molecules
1 publication, 50%
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Citations by publishers
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1
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Springer Nature
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Springer Nature
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 50%
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1
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Vorozhtsov N. O. et al. Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts // Chemistry of Heterocyclic Compounds. 2021. Vol. 57. No. 4. pp. 432-441.
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Vorozhtsov N. O., Yarovaya O. I., Roznyatovskii V. A., Tarasevich B. N., Kozlovskaya Y. A., Petkova A. I., Slita A. V., Sinegubova E. O., Zarubaev V. V., Salakhutdinov N. F., Beloglazkina E. K. Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts // Chemistry of Heterocyclic Compounds. 2021. Vol. 57. No. 4. pp. 432-441.
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TY - JOUR
DO - 10.1007/s10593-021-02921-7
UR - https://doi.org/10.1007%2Fs10593-021-02921-7
TI - Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts
T2 - Chemistry of Heterocyclic Compounds
AU - Vorozhtsov, Nikolai O
AU - Roznyatovskii, Vitalii A
AU - Tarasevich, Boris N
AU - Kozlovskaya, Yuliya A
AU - Petkova, Aneliya I
AU - Slita, Aleksander V
AU - Sinegubova, Ekaterina O
AU - Zarubaev, Vladimir V.
AU - Salakhutdinov, Nariman F.
AU - Beloglazkina, Elena K
AU - Yarovaya, Olga I.
PY - 2021
DA - 2021/04/01 00:00:00
PB - Springer Nature
SP - 432-441
IS - 4
VL - 57
SN - 0009-3122
SN - 1573-8353
ER -
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@article{2021_Vorozhtsov,
author = {Nikolai O Vorozhtsov and Vitalii A Roznyatovskii and Boris N Tarasevich and Yuliya A Kozlovskaya and Aneliya I Petkova and Aleksander V Slita and Ekaterina O Sinegubova and Vladimir V. Zarubaev and Nariman F. Salakhutdinov and Elena K Beloglazkina and Olga I. Yarovaya},
title = {Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts},
journal = {Chemistry of Heterocyclic Compounds},
year = {2021},
volume = {57},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007%2Fs10593-021-02921-7},
number = {4},
pages = {432--441},
doi = {10.1007/s10593-021-02921-7}
}
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Vorozhtsov, Nikolai O., et al. “Synthesis and antiviral activity of novel 3-substituted pyrazolinium salts.” Chemistry of Heterocyclic Compounds, vol. 57, no. 4, Apr. 2021, pp. 432-441. https://doi.org/10.1007%2Fs10593-021-02921-7.
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