Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds

Тип документаJournal Article
Дата публикации2020-04-28
Название журналаOrganic and Biomolecular Chemistry
ИздательThe Royal Society of Chemistry
КвартильQ1
ISSN14770520, 14770539
  • Organic Chemistry
  • Biochemistry
  • Physical and Theoretical Chemistry
Краткое описание

Comprehensive molecular modeling and kinetic analysis reveal a novel mechanism of the inhibition of the oncogenic mutant of the “undruggable” KRAS protein.

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1. Khrenova M.G., Kulakova A.M., Nemukhin A.V. Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds // Organic & Biomolecular Chemistry. 2020. Т. 18. № 16. С. 3069–3081.
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TY - JOUR

DO - 10.1039/d0ob00071j

UR - http://dx.doi.org/10.1039/d0ob00071j

TI - Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of KRASG12C and ARS compounds

T2 - Organic & Biomolecular Chemistry

AU - Khrenova, Maria G.

AU - Kulakova, Anna M.

AU - Nemukhin, Alexander V.

PY - 2020

PB - Royal Society of Chemistry (RSC)

SP - 3069-3081

IS - 16

VL - 18

SN - 1477-0520

SN - 1477-0539

ER -

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@article{2020,

doi = {10.1039/d0ob00071j},

url = {https://doi.org/10.1039%2Fd0ob00071j},

year = 2020,

publisher = {Royal Society of Chemistry ({RSC})},

volume = {18},

number = {16},

pages = {3069--3081},

author = {Maria G. Khrenova and Anna M. Kulakova and Alexander V. Nemukhin},

title = {Proof of concept for poor inhibitor binding and efficient formation of covalent adducts of {KRASG}12C and {ARS} compounds}

}

MLA
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Khrenova, Maria G., Anna M. Kulakova, and Alexander V. Nemukhin. “Proof of Concept for Poor Inhibitor Binding and Efficient Formation of Covalent Adducts of KRASG12C and ARS Compounds.” Organic & Biomolecular Chemistry 18.16 (2020): 3069–3081. Crossref. Web.