Magnetic Resonance in Medicine, volume 84, issue 4, pages 2117-2123

19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane

Publication typeJournal Article
Publication date2020-04-10
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor3.3
ISSN07403194, 15222594
Radiology Nuclear Medicine and imaging
Abstract
Purpose

The aim of this study was to demonstrate the feasibility of fluorine‐19 (19F) MRI of the human lungs using octafluorocyclobutane (OFCB, C4F8). This gas has 8 magnetically equivalent fluorine nuclei and relatively long T1 and T2 (˜50 ms), which render it suitable as an MRI contrast agent. Previous experiments in small laboratory animals showed that OFCB could be successfully used as an alternative to the gases often used for 19F MRI (sulfur hexafluoride and perfluoropropane).

Methods

One male volunteer participated in this study. Immediately before an MRI scan, the volunteer inhaled the gas mixture—80% OFCB with 20% oxygen—and held his breath. Experiments were performed on a 0.5T whole‐body MR scanner with a customized transmit–receive coil tuned at 19F frequency. Fast spin echo in 2D and 3D modes was used for image acquisition. 2D images were obtained with in‐plane resolution of 10 × 10 mm2 without slice selection. 3D images were obtained with the voxel size of 10 × 10 × 30 mm2. Breath‐hold duration was 20 s for 2D and 40 s for 3D imaging, respectively.

Results

Anatomically consistent 19F MR images of the human lungs were obtained with SNR around 50 in 2D mode and 20 in 3D mode. 3D volumetric images of the lungs were reconstructed and provided physiologically reasonable volume estimates.

Conclusion

The application of OFCB enables informative 19F lung imaging even at low magnetic field strengths. The OFCB gas shows promise as an inhalable contrast agent for fluorine lung MRI and has a potential for clinical translation.

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GOST Copy
Pavlova O. S. et al. 19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane // Magnetic Resonance in Medicine. 2020. Vol. 84. No. 4. pp. 2117-2123.
GOST all authors (up to 50) Copy
Pavlova O. S., Anisimov N. V., Gervits L. L., Gulyaev M., Semenova V. N., Pirogov Y. A., Panchenko V. Y. 19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane // Magnetic Resonance in Medicine. 2020. Vol. 84. No. 4. pp. 2117-2123.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1002/mrm.28270
UR - https://doi.org/10.1002%2Fmrm.28270
TI - 19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane
T2 - Magnetic Resonance in Medicine
AU - Gervits, Lev L.
AU - Semenova, Valentina N
AU - Pirogov, Yury A.
AU - Panchenko, Vladislav Ya.
AU - Pavlova, Olga S
AU - Gulyaev, Mikhail
AU - Anisimov, N V
PY - 2020
DA - 2020/04/10 00:00:00
PB - Wiley
SP - 2117-2123
IS - 4
VL - 84
SN - 0740-3194
SN - 1522-2594
ER -
BibTex |
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BibTex Copy
@article{2020_Pavlova
author = {Lev L. Gervits and Valentina N Semenova and Yury A. Pirogov and Vladislav Ya. Panchenko and Olga S Pavlova and Mikhail Gulyaev and N V Anisimov},
title = {19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane},
journal = {Magnetic Resonance in Medicine},
year = {2020},
volume = {84},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1002%2Fmrm.28270},
number = {4},
pages = {2117--2123},
doi = {10.1002/mrm.28270}
}
MLA
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MLA Copy
Pavlova, Olga S., et al. “19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane.” Magnetic Resonance in Medicine, vol. 84, no. 4, Apr. 2020, pp. 2117-2123. https://doi.org/10.1002%2Fmrm.28270.
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