Journal of Cell Biology, volume 220, issue 8
Treacle and TOPBP1 control replication stress response in the nucleolus
Velichko Artem K.
1, 2, 3
,
Petrova Nadezhda V.
1
,
Luzhin Artem V
1, 2
,
Vorobjeva M.
1
,
Kireev I.
4, 6
,
Разин С. В.
1
,
5
Publication type: Journal Article
Publication date: 2021-06-08
Journal:
Journal of Cell Biology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.8
ISSN: 00219525, 15408140
PubMed ID:
34100862
Cell Biology
Abstract
Replication stress is one of the main sources of genome instability. Although the replication stress response in eukaryotic cells has been extensively studied, almost nothing is known about the replication stress response in nucleoli. Here, we demonstrate that initial replication stress–response factors, such as RPA, TOPBP1, and ATR, are recruited inside the nucleolus in response to drug-induced replication stress. The role of TOPBP1 goes beyond the typical replication stress response; it interacts with the low-complexity nucleolar protein Treacle (also referred to as TCOF1) and forms large Treacle–TOPBP1 foci inside the nucleolus. In response to replication stress, Treacle and TOPBP1 facilitate ATR signaling at stalled replication forks, reinforce ATR-mediated checkpoint activation inside the nucleolus, and promote the recruitment of downstream replication stress response proteins inside the nucleolus without forming nucleolar caps. Characterization of the Treacle–TOPBP1 interaction mode leads us to propose that these factors can form a molecular platform for efficient stress response in the nucleolus.
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2 publications, 18.18%
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Velichko A. K. et al. Treacle and TOPBP1 control replication stress response in the nucleolus // Journal of Cell Biology. 2021. Vol. 220. No. 8.
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Velichko A. K., Ovsyannikova N., Petrova N. V., Luzhin A. V., Vorobjeva M., Gavrikov A. S., Mishin A. S., Kireev I., Разин С. В., Kantidze O. L. Treacle and TOPBP1 control replication stress response in the nucleolus // Journal of Cell Biology. 2021. Vol. 220. No. 8.
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TY - JOUR
DO - 10.1083/jcb.202008085
UR - https://doi.org/10.1083%2Fjcb.202008085
TI - Treacle and TOPBP1 control replication stress response in the nucleolus
T2 - Journal of Cell Biology
AU - Velichko, Artem K.
AU - Ovsyannikova, Natalia
AU - Vorobjeva, M.
AU - Mishin, Alexander S.
AU - Kireev, I.
AU - Разин, С. В.
AU - Kantidze, Omar L.
AU - Gavrikov, Alexey S
AU - Petrova, Nadezhda V.
AU - Luzhin, Artem V
PY - 2021
DA - 2021/06/08 00:00:00
PB - Rockefeller University Press
IS - 8
VL - 220
PMID - 34100862
SN - 0021-9525
SN - 1540-8140
ER -
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@article{2021_Velichko,
author = {Artem K. Velichko and Natalia Ovsyannikova and M. Vorobjeva and Alexander S. Mishin and I. Kireev and С. В. Разин and Omar L. Kantidze and Alexey S Gavrikov and Nadezhda V. Petrova and Artem V Luzhin},
title = {Treacle and TOPBP1 control replication stress response in the nucleolus},
journal = {Journal of Cell Biology},
year = {2021},
volume = {220},
publisher = {Rockefeller University Press},
month = {jun},
url = {https://doi.org/10.1083%2Fjcb.202008085},
number = {8},
doi = {10.1083/jcb.202008085}
}