Open Access
Cells, volume 9, issue 6, pages 1423
Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization
Luzhin Artem V.
1, 2
,
Avanesyan Bogdan
2
,
Velichko Artem K.
1, 2, 3
,
Shender Victoria O
4, 5
,
Arapidi Georgij P.
4, 5, 7
,
Petrova Nadezhda V.
2
,
Kireev Igor I
6, 8
,
Разин С. В.
2, 9
,
Publication type: Journal Article
Publication date: 2020-06-08
PubMed ID:
32521766
General Medicine
Abstract
Hyperthermia has been used as an adjuvant treatment for radio- and chemotherapy for decades. In addition to its effects on perfusion and oxygenation of cancer tissues, hyperthermia can enhance the efficacy of DNA-damaging treatments such as radiotherapy and chemotherapy. Although it is believed that the adjuvant effects are based on hyperthermia-induced dysfunction of DNA repair systems, the mechanisms of these dysfunctions remain elusive. Here, we propose that elevated temperatures can induce chromatin trapping (c-trapping) of essential factors, particularly those involved in DNA repair, and thus enhance the sensitization of cancer cells to DNA-damaging therapeutics. Using mass spectrometry-based proteomics, we identified proteins that could potentially undergo c-trapping in response to hyperthermia. Functional analyses of several identified factors involved in DNA repair demonstrated that c-trapping could indeed be a mechanism of hyperthermia-induced transient deficiency of DNA repair systems. Based on our proteomics data, we showed for the first time that hyperthermia could inhibit maturation of Okazaki fragments and activate a corresponding poly(ADP-ribose) polymerase-dependent DNA damage response. Together, our data suggest that chromatin trapping of factors involved in DNA repair and replication contributes to heat-induced radio- and chemosensitization.
Citations by journals
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1
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Journal of Controlled Release
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Journal of Controlled Release
1 publication, 33.33%
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BioEssays
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BioEssays
1 publication, 33.33%
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Annals of Translational Medicine
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Annals of Translational Medicine
1 publication, 33.33%
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1
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Citations by publishers
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1
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Elsevier
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Elsevier
1 publication, 33.33%
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Wiley
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Wiley
1 publication, 33.33%
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AME Publishing Company
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AME Publishing Company
1 publication, 33.33%
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1
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Luzhin A. V. et al. Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization // Cells. 2020. Vol. 9. No. 6. p. 1423.
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Luzhin A. V., Avanesyan B., Velichko A. K., Shender V. O., Ovsyannikova N., Arapidi G. P., Shnaider P. V., Petrova N. V., Kireev I. I., Разин С. В., Kantidze O. L. Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization // Cells. 2020. Vol. 9. No. 6. p. 1423.
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TY - JOUR
DO - 10.3390/cells9061423
UR - https://doi.org/10.3390%2Fcells9061423
TI - Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization
T2 - Cells
AU - Avanesyan, Bogdan
AU - Velichko, Artem K.
AU - Shender, Victoria O
AU - Ovsyannikova, Natalia
AU - Kireev, Igor I
AU - Shnaider, Polina V.
AU - Petrova, Nadezhda V.
AU - Luzhin, Artem V.
AU - Arapidi, Georgij P.
AU - Разин, С. В.
AU - Kantidze, Omar L.
PY - 2020
DA - 2020/06/08 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 1423
IS - 6
VL - 9
PMID - 32521766
SN - 2073-4409
ER -
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@article{2020_Luzhin,
author = {Bogdan Avanesyan and Artem K. Velichko and Victoria O Shender and Natalia Ovsyannikova and Igor I Kireev and Polina V. Shnaider and Nadezhda V. Petrova and Artem V. Luzhin and Georgij P. Arapidi and С. В. Разин and Omar L. Kantidze},
title = {Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization},
journal = {Cells},
year = {2020},
volume = {9},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3390%2Fcells9061423},
number = {6},
pages = {1423},
doi = {10.3390/cells9061423}
}
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MLA
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Luzhin, Artem V., et al. “Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization.” Cells, vol. 9, no. 6, Jun. 2020, p. 1423. https://doi.org/10.3390%2Fcells9061423.