Open Access
Open access
Nucleic Acids Research, volume 47, issue 13, pages 6811-6825

Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription

Velichko Artem K. 1, 2
Petrova Nadezhda V. 1
Strelkova Olga S 3
Kireev I. 3, 4
Petrova Nataliya V 5
Разин С. В. 5, 6, 7
Publication typeJournal Article
Publication date2019-05-22
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor14.9
ISSN03051048, 13624962
PubMed ID:  31114877
Genetics
Abstract

The contribution of nucleoli to the cellular stress response has been discussed for over a decade. Stress-induced inhibition of RNA polymerase I-dependent transcription is hypothesized as a possible effector program in such a response. In this study, we report a new mechanism by which ribosomal DNA transcription can be inhibited in response to cellular stress. Specifically, we demonstrate that mild hypoosmotic stress induces stabilization of R loops in ribosomal genes and thus provokes the nucleoli-specific DNA damage response, which is governed by the ATM- and Rad3-related (ATR) kinase. Activation of ATR in nucleoli strongly depends on Treacle, which is needed for efficient recruitment/retention of TopBP1 in nucleoli. Subsequent ATR-mediated activation of ATM results in repression of nucleolar transcription.

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Velichko A. K. et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription // Nucleic Acids Research. 2019. Vol. 47. No. 13. pp. 6811-6825.
GOST all authors (up to 50) Copy
Velichko A. K., Petrova N. V., Luzhin A. V., Strelkova O. S., Ovsyannikova N., Kireev I., Petrova N. V., Разин С. В., Kantidze O. L. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription // Nucleic Acids Research. 2019. Vol. 47. No. 13. pp. 6811-6825.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1093/nar/gkz436
UR - https://doi.org/10.1093%2Fnar%2Fgkz436
TI - Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription
T2 - Nucleic Acids Research
AU - Velichko, Artem K.
AU - Petrova, Nadezhda V.
AU - Strelkova, Olga S
AU - Luzhin, Artem V.
AU - Ovsyannikova, Natalia
AU - Kireev, I.
AU - Petrova, Nataliya V
AU - Разин, С. В.
AU - Kantidze, Omar L.
PY - 2019
DA - 2019/05/22 00:00:00
PB - Oxford University Press
SP - 6811-6825
IS - 13
VL - 47
PMID - 31114877
SN - 0305-1048
SN - 1362-4962
ER -
BibTex |
Cite this
BibTex Copy
@article{2019_Velichko
author = {Artem K. Velichko and Nadezhda V. Petrova and Olga S Strelkova and Artem V. Luzhin and Natalia Ovsyannikova and I. Kireev and Nataliya V Petrova and С. В. Разин and Omar L. Kantidze},
title = {Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription},
journal = {Nucleic Acids Research},
year = {2019},
volume = {47},
publisher = {Oxford University Press},
month = {may},
url = {https://doi.org/10.1093%2Fnar%2Fgkz436},
number = {13},
pages = {6811--6825},
doi = {10.1093/nar/gkz436}
}
MLA
Cite this
MLA Copy
Velichko, Artem K., et al. “Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription.” Nucleic Acids Research, vol. 47, no. 13, May. 2019, pp. 6811-6825. https://doi.org/10.1093%2Fnar%2Fgkz436.
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