Open Access
Journal of Magnesium and Alloys, volume 10, issue 6, pages 1631-1639
In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation
Tie Di
1, 2
,
Guan Renguo
1
,
Liu Huinan
3
,
Chen Minfang
4
,
Holt-Torres Patricia
3
,
Lu Xiaopeng
2
,
Hort Norbert
6
3
Department of Bioengineering, University of California, Riverside, CA 92521, USA
|
4
6
Magnesium Innovation Center – MAGIC, Helmholtz Zentrum Geesthacht, Geesthacht D-21502, Germany
|
Publication type: Journal Article
Publication date: 2022-06-01
Journal:
Journal of Magnesium and Alloys
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 17.6
ISSN: 22139567
Metals and Alloys
Mechanics of Materials
Abstract
Abstract The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades, among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial activity. Here, we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig model. Refined non-dendritic microstructure was observed in the rheo-formed alloy, which led to ca. 47% increase in ultimate tensile strength (from 195.0 MPa to 288.1 MPa) and more homogeneous degradation process compared with the untreated alloy. No post-interventional inflammation or pathological changes of the test animals were observed during the implantation period, and the corrosion rate (0.22 ± 0.04 mm·y−1) perfectly fitted the clinical ureteral stent indwelling time. The urine bacteria numbers decreased from 88 ± 13 CFU·mL−1 at 7 weeks post operation to 59 ± 8 CFU·mL−1 at 14 weeks post operation, which confirmed the evident antibacterial activity of the alloy. Our study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system, enabling its efficacious use as ureteral implant materials.
Citations by journals
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1
2
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Journal of Magnesium and Alloys
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Journal of Magnesium and Alloys
2 publications, 18.18%
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ACS Applied Bio Materials
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ACS Applied Bio Materials
2 publications, 18.18%
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Corrosion and Materials Degradation
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Corrosion and Materials Degradation
1 publication, 9.09%
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Materials Today Communications
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Materials Today Communications
1 publication, 9.09%
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Frontiers in Bioengineering and Biotechnology
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Frontiers in Bioengineering and Biotechnology
1 publication, 9.09%
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Materials
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Materials
1 publication, 9.09%
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Acta Biomaterialia
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Acta Biomaterialia
1 publication, 9.09%
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Materials Transactions
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Materials Transactions
1 publication, 9.09%
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Journal of Materials Research and Technology
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Journal of Materials Research and Technology
1 publication, 9.09%
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1
2
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Citations by publishers
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1
2
3
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Elsevier
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Elsevier
3 publications, 27.27%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 18.18%
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KeAi Communications Co.
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KeAi Communications Co.
2 publications, 18.18%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 18.18%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 9.09%
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Japan Institute of Metals and Materials
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Japan Institute of Metals and Materials
1 publication, 9.09%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Tie D. et al. In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation // Journal of Magnesium and Alloys. 2022. Vol. 10. No. 6. pp. 1631-1639.
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Tie D., Guan R., Liu H., Chen M., Ulasevich S. A., Skorb E. V., Holt-Torres P., Lu X., Hort N. In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation // Journal of Magnesium and Alloys. 2022. Vol. 10. No. 6. pp. 1631-1639.
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TY - JOUR
DO - 10.1016/j.jma.2020.11.005
UR - https://doi.org/10.1016%2Fj.jma.2020.11.005
TI - In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation
T2 - Journal of Magnesium and Alloys
AU - Tie, Di
AU - Guan, Renguo
AU - Liu, Huinan
AU - Chen, Minfang
AU - Ulasevich, Sviatlana A
AU - Skorb, Ekaterina V.
AU - Holt-Torres, Patricia
AU - Lu, Xiaopeng
AU - Hort, Norbert
PY - 2022
DA - 2022/06/01 00:00:00
PB - KeAi Communications Co.
SP - 1631-1639
IS - 6
VL - 10
SN - 2213-9567
ER -
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@article{2022_Tie,
author = {Di Tie and Renguo Guan and Huinan Liu and Minfang Chen and Sviatlana A Ulasevich and Ekaterina V. Skorb and Patricia Holt-Torres and Xiaopeng Lu and Norbert Hort},
title = {In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation},
journal = {Journal of Magnesium and Alloys},
year = {2022},
volume = {10},
publisher = {KeAi Communications Co.},
month = {jun},
url = {https://doi.org/10.1016%2Fj.jma.2020.11.005},
number = {6},
pages = {1631--1639},
doi = {10.1016/j.jma.2020.11.005}
}
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Tie, Di, et al. “In vivo degradability and biocompatibility of a rheo-formed Mg–Zn–Sr alloy for ureteral implantation.” Journal of Magnesium and Alloys, vol. 10, no. 6, Jun. 2022, pp. 1631-1639. https://doi.org/10.1016%2Fj.jma.2020.11.005.
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