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Molecules, volume 26, issue 23, pages 7179

Amination of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2h-pyrrol-2-ones

Publication typeJournal Article
Publication date2021-11-26
Journal: Molecules
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor4.6
ISSN14203049
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract

The 3-hydroxy-1,5-dihydro-2H-pyrrol-2-one motif is a valuable scaffold in drug discovery. The replacement of the 3-oxy fragment in 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones-based compounds with a 3-amino one (3-amino analogs of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, 3-amino-1,5-dihydro-2H-pyrrol-2-ones) can play a crucial role in their biological effect. Thus, approaches to 3-amino-1,5-dihydro-2H-pyrrol-2-ones are of significant interest. We developed an approach to 5-spiro-substituted 3-amino-1,5-dihydro-2H-pyrrol-2-ones that could not be obtained using previously reported approaches (reactions of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones with amines). The developed approach is based on the thermal decomposition of 1,3-disubstituted urea derivatives of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones, which were prepared via their reaction with carbodiimides.

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Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, 1, 100%
Beilstein Journal of Organic Chemistry
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Beilstein-Institut
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Khramtsova E. E. et al. Amination of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2h-pyrrol-2-ones // Molecules. 2021. Vol. 26. No. 23. p. 7179.
GOST all authors (up to 50) Copy
Khramtsova E. E., Lystsova E. A., Khokhlova E. V., Dmitriev M. V., Maslivets A. N. Amination of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2h-pyrrol-2-ones // Molecules. 2021. Vol. 26. No. 23. p. 7179.
RIS |
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RIS Copy
TY - JOUR
DO - 10.3390/molecules26237179
UR - https://doi.org/10.3390%2Fmolecules26237179
TI - Amination of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2h-pyrrol-2-ones
T2 - Molecules
AU - Khokhlova, Evgeniya V
AU - Khramtsova, Ekaterina E
AU - Lystsova, E A
AU - Dmitriev, Maksim V
AU - Maslivets, Andrey N
PY - 2021
DA - 2021/11/26 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 7179
IS - 23
VL - 26
SN - 1420-3049
ER -
BibTex |
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BibTex Copy
@article{2021_Khramtsova
author = {Evgeniya V Khokhlova and Ekaterina E Khramtsova and E A Lystsova and Maksim V Dmitriev and Andrey N Maslivets},
title = {Amination of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2h-pyrrol-2-ones},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {nov},
url = {https://doi.org/10.3390%2Fmolecules26237179},
number = {23},
pages = {7179},
doi = {10.3390/molecules26237179}
}
MLA
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MLA Copy
Khramtsova, Ekaterina E., et al. “Amination of 5-spiro-substituted 3-hydroxy-1,5-dihydro-2h-pyrrol-2-ones.” Molecules, vol. 26, no. 23, Nov. 2021, p. 7179. https://doi.org/10.3390%2Fmolecules26237179.
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