Open Access

Frontiers in Cell and Developmental Biology, volume 9

Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses

Shliapina Viktoriia ¹

Koriagina Mariia ²

Vasilkova Daria ²

Govorun Vadim ³

Dontsova Olga ^{1, 2, 4}

Rubtsova Maria ²

Hide authors affiliations Show authors affiliations: 4 affiliations

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Russia |

Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Russia |

Federal Research and Clinical Centre of Physical-Chemical Medicine, Russia |

⁴

Center of Life Sciences, Skolkovo Institute of Science and Technology, Russia |

Publication type: Journal Article

Publication date: 2021-12-07

Frontiers Media S.A.

Journal: Frontiers in Cell and Developmental Biology

Quartile SCImago

Quartile WOS

Impact factor: 5.5

ISSN: 2296634X

DOI: 10.3389/fcell.2021.754611

Copy DOI

PubMed ID: 34950657

Cell Biology

Developmental Biology

Abstract

Cell proliferation is associated with increased energy and nutrients consumption. Metabolism switch from oxidative phosphorylation to glycolysis and telomerase activity are induced during stimulation of proliferation, such as tumorigenesis, immune cell activation, and stem cell differentiation, among others. Telomerase RNA is one of the core components of the telomerase complex and participates in survival mechanisms that are activated under stress conditions. Human telomerase RNA protein (hTERP) is encoded by telomerase RNA and has been recently shown to be involved in autophagy regulation. In this study, we demonstrated the role of hTERP in the modulation of signaling pathways regulating autophagy, protein biosynthesis, and cell proliferation. The AMPK signaling pathway was affected in cells deficient of hTERP and when hTERP was overexpressed. The appearance of hTERP is important for metabolism switching associated with the accelerated proliferation of cells in healthy and pathological processes. These findings demonstrate the connection between telomerase RNA biogenesis and function and signaling pathways.

By date By citations

Citations by journals

	1 2
Biomedicines	Biomedicines, 2, 40% Biomedicines 2 publications, 40%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 20% International Journal of Molecular Sciences 1 publication, 20%
Doklady Biochemistry and Biophysics	Doklady Biochemistry and Biophysics, 1, 20% Doklady Biochemistry and Biophysics 1 publication, 20%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 20% Biomedicine and Pharmacotherapy 1 publication, 20%
	1 2

Citations by publishers

	1 2 3
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 60% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 60%
Pleiades Publishing	Pleiades Publishing, 1, 20% Pleiades Publishing 1 publication, 20%
Elsevier	Elsevier, 1, 20% Elsevier 1 publication, 20%
	1 2 3

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023],"ids":[0,0],"codes":[0,0],"imageUrls":["",""],"datasets":[{"label":"Citations number","data":[1,4],"backgroundColor":["#3B82F6","#3B82F6"],"percentage":["20","80"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Biomedicines","International Journal of Molecular Sciences","Doklady Biochemistry and Biophysics","Biomedicine and Pharmacotherapy"],"ids":[24421,14627,3773,23951],"codes":[0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[2,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[40,20,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Pleiades Publishing","Elsevier"],"ids":[202,101,17],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[3,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[60,20,20],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Shliapina V. et al. Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses // Frontiers in Cell and Developmental Biology. 2021. Vol. 9.

GOST all authors (up to 50) Copy

Shliapina V., Koriagina M., Vasilkova D., Govorun V., Dontsova O., Rubtsova M. Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses // Frontiers in Cell and Developmental Biology. 2021. Vol. 9.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3389/fcell.2021.754611

UR - https://doi.org/10.3389%2Ffcell.2021.754611

TI - Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses

T2 - Frontiers in Cell and Developmental Biology

AU - Shliapina, Viktoriia

AU - Koriagina, Mariia

AU - Vasilkova, Daria

AU - Govorun, Vadim

AU - Dontsova, Olga

AU - Rubtsova, Maria

PY - 2021

DA - 2021/12/07 00:00:00

PB - Frontiers Media S.A.

VL - 9

PMID - 34950657

SN - 2296-634X

ER -

BibTex

Cite this

BibTex Copy

@article{2021_Shliapina,

author = {Viktoriia Shliapina and Mariia Koriagina and Daria Vasilkova and Vadim Govorun and Olga Dontsova and Maria Rubtsova},

title = {Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses},

journal = {Frontiers in Cell and Developmental Biology},

year = {2021},

volume = {9},

publisher = {Frontiers Media S.A.},

month = {dec},

url = {https://doi.org/10.3389%2Ffcell.2021.754611},

doi = {10.3389/fcell.2021.754611}

}

Found error?

Publisher

Frontiers Media S.A.

Journal

Frontiers in Cell and Developmental Biology

Quartile SCImago

Quartile WOS

Impact factor

5.5

ISSN

2296634X (Electronic)

Labs

Laboratory of Nucleoprotein Chemistry, Department of Chemistry of Natural Compounds, Faculty of Chemistry

Profiles