Open Access
Molecules, volume 26, issue 21, pages 6537
Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy
Popova Tatyana N
1, 2
,
Дымова М. А.
1
,
Zakharova Olga D
1
,
Raskolupova Valeria I
1, 2
,
Sycheva Tatiana
3
,
Taskaev Sergei
2, 3
,
Sil’nikov Vladimir N
1
,
Godovikova Tatyana S
1, 2
Publication type: Journal Article
Publication date: 2021-10-29
PubMed ID:
34770947
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Boron neutron capture therapy is a unique form of adjuvant cancer therapy for various malignancies including malignant gliomas. The conjugation of boron compounds and human serum albumin (HSA)—a carrier protein with a long plasma half-life—is expected to extend systemic circulation of the boron compounds and increase their accumulation in human glioma cells. We report on the synthesis of fluorophore-labeled homocystamide conjugates of human serum albumin and their use in thiol-‘click’ chemistry to prepare novel multimodal boronated albumin-based theranostic agents, which could be accumulated in tumor cells. The novelty of this work involves the development of the synthesis methodology of albumin conjugates for the imaging-guided boron neutron capture therapy combination. Herein, we suggest using thenoyltrifluoroacetone as a part of an anticancer theranostic construct: approximately 5.4 molecules of thenoyltrifluoroacetone were bound to each albumin. Along with its beneficial properties as a chemotherapeutic agent, thenoyltrifluoroacetone is a promising magnetic resonance imaging agent. The conjugation of bimodal HSA with undecahydro-closo-dodecaborate only slightly reduced human glioma cell line viability in the absence of irradiation (~30 μM of boronated albumin) but allowed for neutron capture and decreased tumor cell survival under epithermal neutron flux. The simultaneous presence of undecahydro-closo-dodecaborate and labeled amino acid residues (fluorophore dye and fluorine atoms) in the obtained HSA conjugate makes it a promising candidate for the combination imaging-guided boron neutron capture therapy.
Citations by journals
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Molecules
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2 publications, 28.57%
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Journal of Neutron Research
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Medicinal Research Reviews
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Citations by publishers
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1
2
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 28.57%
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IOS Press
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1 publication, 14.29%
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Wiley
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1 publication, 14.29%
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Elsevier
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Elsevier
1 publication, 14.29%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 14.29%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Popova T. N. et al. Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy // Molecules. 2021. Vol. 26. No. 21. p. 6537.
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Popova T. N., Дымова М. А., Koroleva M. S., Zakharova O. D., Lisitskiy V. A., Raskolupova V. I., Sycheva T., Taskaev S., Sil’nikov V. N., Godovikova T. S. Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy // Molecules. 2021. Vol. 26. No. 21. p. 6537.
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TY - JOUR
DO - 10.3390/molecules26216537
UR - https://doi.org/10.3390%2Fmolecules26216537
TI - Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy
T2 - Molecules
AU - Raskolupova, Valeria I
AU - Sycheva, Tatiana
AU - Sil’nikov, Vladimir N
AU - Godovikova, Tatyana S
AU - Popova, Tatyana N
AU - Дымова, М. А.
AU - Koroleva, Mariia S
AU - Zakharova, Olga D
AU - Lisitskiy, Vladimir A
AU - Taskaev, Sergei
PY - 2021
DA - 2021/10/29 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 6537
IS - 21
VL - 26
PMID - 34770947
SN - 1420-3049
ER -
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@article{2021_Popova,
author = {Valeria I Raskolupova and Tatiana Sycheva and Vladimir N Sil’nikov and Tatyana S Godovikova and Tatyana N Popova and М. А. Дымова and Mariia S Koroleva and Olga D Zakharova and Vladimir A Lisitskiy and Sergei Taskaev},
title = {Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {oct},
url = {https://doi.org/10.3390%2Fmolecules26216537},
number = {21},
pages = {6537},
doi = {10.3390/molecules26216537}
}
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MLA
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Popova, Tatyana N., et al. “Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy.” Molecules, vol. 26, no. 21, Oct. 2021, p. 6537. https://doi.org/10.3390%2Fmolecules26216537.