Open Access
International Journal of Molecular Sciences, volume 23, issue 1, pages 483
Gut Microbiota as a Source of Uremic Toxins
Popkov Vasily A.
1, 2
,
Zharikova Anastasia A.
1, 3
,
Demchenko Evgenia A
1
,
Andrianova Nadezda V.
1
,
Зоров Д. Б.
1, 2
,
Plotnikov Egor Yu
1, 2
Publication type: Journal Article
Publication date: 2022-01-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.6
ISSN: 16616596, 14220067
Catalysis
Organic Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Computer Science Applications
Spectroscopy
Molecular Biology
General Medicine
Abstract
Uremic retention solutes are the compounds that accumulate in the blood when kidney excretory function is impaired. Some of these compounds are toxic at high concentrations and are usually known as “uremic toxins”. The cumulative detrimental effect of uremic toxins results in numerous health problems and eventually mortality during acute or chronic uremia, especially in end-stage renal disease. More than 100 different solutes increase during uremia; however, the exact origin for most of them is still debatable. There are three main sources for such compounds: exogenous ones are consumed with food, whereas endogenous ones are produced by the host metabolism or by symbiotic microbiota metabolism. In this article, we identify uremic retention solutes presumably of gut microbiota origin. We used database analysis to obtain data on the enzymatic reactions in bacteria and human organisms that potentially yield uremic retention solutes and hence to determine what toxins could be synthesized in bacteria residing in the human gut. We selected biochemical pathways resulting in uremic retention solutes synthesis related to specific bacterial strains and revealed links between toxin concentration in uremia and the proportion of different bacteria species which can synthesize the toxin. The detected bacterial species essential for the synthesis of uremic retention solutes were then verified using the Human Microbiome Project database. Moreover, we defined the relative abundance of human toxin-generating enzymes as well as the possibility of the synthesis of a particular toxin by the human metabolism. Our study presents a novel bioinformatics approach for the elucidation of the origin of both uremic retention solutes and uremic toxins and for searching for the most likely human microbiome producers of toxins that can be targeted and used for the therapy of adverse consequences of uremia.
Citations by journals
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Citations by publishers
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1
2
3
4
5
6
7
8
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Multidisciplinary Digital Publishing Institute (MDPI)
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8 publications, 44.44%
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3 publications, 16.67%
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SAGE
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1 publication, 5.56%
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Springer Nature
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1 publication, 5.56%
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American Physiological Society
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1 publication, 5.56%
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Elsevier
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1 publication, 5.56%
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1 publication, 5.56%
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1 publication, 5.56%
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1
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3
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5
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8
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Popkov V. A. et al. Gut Microbiota as a Source of Uremic Toxins // International Journal of Molecular Sciences. 2022. Vol. 23. No. 1. p. 483.
GOST all authors (up to 50)
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Popkov V. A., Zharikova A. A., Demchenko E. A., Andrianova N. V., Зоров Д. Б., Plotnikov E. Yu. Gut Microbiota as a Source of Uremic Toxins // International Journal of Molecular Sciences. 2022. Vol. 23. No. 1. p. 483.
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TY - JOUR
DO - 10.3390/ijms23010483
UR - https://doi.org/10.3390%2Fijms23010483
TI - Gut Microbiota as a Source of Uremic Toxins
T2 - International Journal of Molecular Sciences
AU - Demchenko, Evgenia A
AU - Zharikova, Anastasia A.
AU - Andrianova, Nadezda V.
AU - Popkov, Vasily A.
AU - Зоров, Д. Б.
AU - Plotnikov, Egor Yu
PY - 2022
DA - 2022/01/01 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 483
IS - 1
VL - 23
SN - 1661-6596
SN - 1422-0067
ER -
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@article{2022_Popkov,
author = {Evgenia A Demchenko and Anastasia A. Zharikova and Nadezda V. Andrianova and Vasily A. Popkov and Д. Б. Зоров and Egor Yu Plotnikov},
title = {Gut Microbiota as a Source of Uremic Toxins},
journal = {International Journal of Molecular Sciences},
year = {2022},
volume = {23},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jan},
url = {https://doi.org/10.3390%2Fijms23010483},
number = {1},
pages = {483},
doi = {10.3390/ijms23010483}
}
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MLA
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Popkov, Vasily A., et al. “Gut Microbiota as a Source of Uremic Toxins.” International Journal of Molecular Sciences, vol. 23, no. 1, Jan. 2022, p. 483. https://doi.org/10.3390%2Fijms23010483.