Mendeleev Communications, volume 28, issue 3, pages 317-319
Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers
Publication type: Journal Article
Publication date: 2018-05-26
Journal:
Mendeleev Communications
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.9
ISSN: 09599436, 1364551X
General Chemistry
Abstract
Racemic Albicar (2,6-diethyl-4,8-dimethylglycoluril) has been synthesized and resolved into enantiomers on a preparative scale by chiral HPLC. A comparison of the pharmacological effects of these compounds has been performed for the first time. It has been demonstrated that the (−)-(1S,5S)-enantiomer exerts a stimulating effect on the central nervous system due to activation of the serotonergic system, since it potentiates the effects of 5-hydroxytryptophan (the serotonin precursor), while the antagonist of serotonin receptors blocks its activity; the (+)-(1R,5R)-enantiomer evinces an inhibitory effect.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Anikina L. V. et al. Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 317-319.
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Anikina L. V., Vikharev Y. B., Baranov V. V., Malyshev O. R., Kravchenko A. N., Malyshev O. B. Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 317-319.
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TY - JOUR
DO - 10.1016/J.MENCOM.2018.05.030
UR - https://doi.org/10.1016%2FJ.MENCOM.2018.05.030
TI - Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers
T2 - Mendeleev Communications
AU - Anikina, Lada V
AU - Vikharev, Yuri B
AU - Baranov, Vladimir V.
AU - Malyshev, Oleg R
AU - Kravchenko, Angelina N.
AU - Malyshev, O. B.
PY - 2018
DA - 2018/05/26 00:00:00
PB - Elsevier
SP - 317-319
IS - 3
VL - 28
SN - 0959-9436
SN - 1364-551X
ER -
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@article{2018_Anikina
author = {Lada V Anikina and Yuri B Vikharev and Vladimir V. Baranov and Oleg R Malyshev and Angelina N. Kravchenko and O. B. Malyshev},
title = {Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2FJ.MENCOM.2018.05.030},
number = {3},
pages = {317--319},
doi = {10.1016/J.MENCOM.2018.05.030}
}
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MLA
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Anikina, Lada V., et al. “Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers.” Mendeleev Communications, vol. 28, no. 3, May. 2018, pp. 317-319. https://doi.org/10.1016%2FJ.MENCOM.2018.05.030.