Mendeleev Communications, volume 28, issue 3, pages 317-319

Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers

Publication typeJournal Article
Publication date2018-05-26
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor1.9
ISSN09599436, 1364551X
General Chemistry
Abstract
Racemic Albicar (2,6-diethyl-4,8-dimethylglycoluril) has been synthesized and resolved into enantiomers on a preparative scale by chiral HPLC. A comparison of the pharmacological effects of these compounds has been performed for the first time. It has been demonstrated that the (−)-(1S,5S)-enantiomer exerts a stimulating effect on the central nervous system due to activation of the serotonergic system, since it potentiates the effects of 5-hydroxytryptophan (the serotonin precursor), while the antagonist of serotonin receptors blocks its activity; the (+)-(1R,5R)-enantiomer evinces an inhibitory effect.

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GOST Copy
Anikina L. V. et al. Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 317-319.
GOST all authors (up to 50) Copy
Anikina L. V., Vikharev Y. B., Baranov V. V., Malyshev O. R., Kravchenko A. N., Malyshev O. B. Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers // Mendeleev Communications. 2018. Vol. 28. No. 3. pp. 317-319.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/J.MENCOM.2018.05.030
UR - https://doi.org/10.1016%2FJ.MENCOM.2018.05.030
TI - Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers
T2 - Mendeleev Communications
AU - Anikina, Lada V
AU - Vikharev, Yuri B
AU - Baranov, Vladimir V.
AU - Malyshev, Oleg R
AU - Kravchenko, Angelina N.
AU - Malyshev, O. B.
PY - 2018
DA - 2018/05/26 00:00:00
PB - Elsevier
SP - 317-319
IS - 3
VL - 28
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
Cite this
BibTex Copy
@article{2018_Anikina
author = {Lada V Anikina and Yuri B Vikharev and Vladimir V. Baranov and Oleg R Malyshev and Angelina N. Kravchenko and O. B. Malyshev},
title = {Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers},
journal = {Mendeleev Communications},
year = {2018},
volume = {28},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2FJ.MENCOM.2018.05.030},
number = {3},
pages = {317--319},
doi = {10.1016/J.MENCOM.2018.05.030}
}
MLA
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MLA Copy
Anikina, Lada V., et al. “Preparative synthesis and pharmacological activity of Albicar racemate and enantiomers.” Mendeleev Communications, vol. 28, no. 3, May. 2018, pp. 317-319. https://doi.org/10.1016%2FJ.MENCOM.2018.05.030.
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