Open Access
Infectious Diseases Research and Treatment, volume 9, pages IDRT.S38108
Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment.
Ogunwuyi Oluwaseun
1
,
Kumari Namita
2
,
Smith Kahli A
2, 3
,
Bol'shakov Oleg
1
,
Adesina Simeon
1
,
Gugssa Ayele
4
,
Anderson Winston A.
4
,
Nekhai Sergei
2, 3, 5, 6
,
Akala Emmanuel O.
1
1
Department of Pharmaceutical Sciences, Center for Drug Research and Development (CDRD), College of Pharmacy, Howard University, Washington, DC, USA.
|
2
Center for Sickle Cell Disease, Howard University, Washington, DC, USA.
|
3
Department of Pharmacology, College of Medicine, Howard University, Washington, DC, USA.
|
4
Department of Biology, Howard University, Washington, DC, USA.
|
5
Department of Medicine, College of Medicine, Howard University, Washington, DC, USA.
|
6
Department of Microbiology, College of Medicine, Howard University, Washington, DC, USA.
|
Publication type: Journal Article
Publication date: 2016-01-01
Quartile SCImago
— Quartile WOS
—
Impact factor: —
ISSN: 11786337, 11786337
PubMed ID:
27013886
General Medicine
Abstract
Highly active antiretroviral (ARV) therapy (HAART) for chronic suppression of HIV replication has revolutionized the treatment of HIV/AIDS. HAART is no panacea; treatments must be maintained for life. Although great progress has been made in ARV therapy, HIV continues to replicate in anatomical and intracellular sites where ARV drugs have restricted access. Nanotechnology has been considered a platform to circumvent some of the challenges in HIV/AIDS treatment. Dispersion polymerization was used to fabricate two types (PMM and ECA) of polymeric nanoparticles, and each was successfully loaded with four ARV drugs (zidovudine, lamivudine, nevirapine, and raltegravir), followed by physicochemical characterization: scanning electron microscope, particle size, zeta potential, drug loading, and in vitro availability. These nanoparticles efficiently inhibited HIV-1 infection in CEM T cells and peripheral blood mononuclear cells; they hold promise for the treatment of HIV/AIDS. The ARV-loaded nanoparticles with polyethylene glycol on the corona may facilitate tethering ligands for targeting specific receptors expressed on the cells of HIV reservoirs.
Citations by journals
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1
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Polymers
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Polymers
1 publication, 11.11%
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Drug Delivery and Translational Research
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Drug Delivery and Translational Research
1 publication, 11.11%
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Beni-Suef University Journal of Basic and Applied Sciences
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Beni-Suef University Journal of Basic and Applied Sciences
1 publication, 11.11%
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European Journal of Pharmaceutics and Biopharmaceutics
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European Journal of Pharmaceutics and Biopharmaceutics
1 publication, 11.11%
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Colloids and Surfaces B: Biointerfaces
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Colloids and Surfaces B: Biointerfaces
1 publication, 11.11%
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Crystal Growth and Design
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Crystal Growth and Design
1 publication, 11.11%
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Journal of Drug Targeting
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Journal of Drug Targeting
1 publication, 11.11%
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Frontiers of Nanoscience
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Frontiers of Nanoscience
1 publication, 11.11%
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1
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Citations by publishers
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1
2
3
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Elsevier
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Elsevier
3 publications, 33.33%
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Springer Nature
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Springer Nature
2 publications, 22.22%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 11.11%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 11.11%
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Taylor & Francis
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Taylor & Francis
1 publication, 11.11%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ogunwuyi O. et al. Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment. // Infectious Diseases Research and Treatment. 2016. Vol. 9. p. IDRT.S38108.
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Ogunwuyi O., Kumari N., Smith K. A., Bol'shakov O., Adesina S., Gugssa A., Anderson W. A., Nekhai S., Akala E. O. Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment. // Infectious Diseases Research and Treatment. 2016. Vol. 9. p. IDRT.S38108.
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TY - JOUR
DO - 10.4137/IDRT.S38108
UR - https://doi.org/10.4137%2FIDRT.S38108
TI - Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment.
T2 - Infectious Diseases Research and Treatment
AU - Ogunwuyi, Oluwaseun
AU - Smith, Kahli A
AU - Adesina, Simeon
AU - Gugssa, Ayele
AU - Anderson, Winston A.
AU - Kumari, Namita
AU - Bol'shakov, Oleg
AU - Nekhai, Sergei
AU - Akala, Emmanuel O.
PY - 2016
DA - 2016/01/01 00:00:00
PB - SAGE
SP - IDRT.S38108
VL - 9
PMID - 27013886
SN - 1178-6337
SN - 1178-6337
ER -
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@article{2016_Ogunwuyi,
author = {Oluwaseun Ogunwuyi and Kahli A Smith and Simeon Adesina and Ayele Gugssa and Winston A. Anderson and Namita Kumari and Oleg Bol'shakov and Sergei Nekhai and Emmanuel O. Akala},
title = {Antiretroviral Drugs-Loaded Nanoparticles Fabricated by Dispersion Polymerization with Potential for HIV/AIDS Treatment.},
journal = {Infectious Diseases Research and Treatment},
year = {2016},
volume = {9},
publisher = {SAGE},
month = {jan},
url = {https://doi.org/10.4137%2FIDRT.S38108},
pages = {IDRT.S38108},
doi = {10.4137/IDRT.S38108}
}
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