Open Access
Scientia Pharmaceutica, volume 83, issue 3, pages 535-548
Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound
1
Center for Sickle Cell Disease, Howard University, Washington DC 20059, USA
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2
Department of Pharmacology, Howard University, Washington DC 20059, USA
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Publication type: Journal Article
Publication date: 2015-06-28
Journal:
Scientia Pharmaceutica
Quartile SCImago
Q2
Quartile WOS
—
Impact factor: 2.4
ISSN: 00368709, 22180532
PubMed ID:
26839837
Pharmaceutical Science
Abstract
Complete eradication of HIV-1 infection is impeded by the existence of latent HIV-1 reservoirs in which the integrated HIV-1 provirus is transcriptionally inactive. Activation of HIV-1 transcription requires the viral Tat protein and host cell factors, including protein phosphatase-1 (PP1). We previously developed a library of small compounds that targeted PP1 and identified a compound, SMAPP1, which induced HIV-1 transcription. However, this compound has a limited bioavailability in vivo and may not be able to reach HIV-1-infected cells and induce HIV-1 transcription in patients. We packaged SMAPP1 in polymeric polyethylene glycol polymethyl methacrylate nanoparticles and analyzed its release and the effect on HIV-1 transcription in a cell culture. SMAPP1 was efficiently packaged in the nanoparticles and released during a 120-hr period. Treatment of the HIV-1-infected cells with the SMAPP1-loaded nanoparticles induced HIV-1 transcription. Thus, nanoparticles loaded with HIV-1-targeting compounds might be useful for future anti-HIV-1 therapeutics.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Smith K. A. Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound // Scientia Pharmaceutica. 2015. Vol. 83. No. 3. pp. 535-548.
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Smith K. A. Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound // Scientia Pharmaceutica. 2015. Vol. 83. No. 3. pp. 535-548.
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TY - JOUR
DO - 10.3797/SCIPHARM.1502-01
UR - https://doi.org/10.3797%2FSCIPHARM.1502-01
TI - Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound
T2 - Scientia Pharmaceutica
AU - Smith, Kahli A
PY - 2015
DA - 2015/06/28 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 535-548
IS - 3
VL - 83
PMID - 26839837
SN - 0036-8709
SN - 2218-0532
ER -
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@article{2015_Smith,
author = {Kahli A Smith},
title = {Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound},
journal = {Scientia Pharmaceutica},
year = {2015},
volume = {83},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {jun},
url = {https://doi.org/10.3797%2FSCIPHARM.1502-01},
number = {3},
pages = {535--548},
doi = {10.3797/SCIPHARM.1502-01}
}
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MLA
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Smith, Kahli A.. “Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound.” Scientia Pharmaceutica, vol. 83, no. 3, Jun. 2015, pp. 535-548. https://doi.org/10.3797%2FSCIPHARM.1502-01.
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