Molecular Diversity, volume 20, issue 4, pages 837-846

Substituted N-aminothioglycolurils containing thiosemicarbazone moiety and their cytotoxic activity in vitro

Publication typeJournal Article
Publication date2016-05-23
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor3.8
ISSN13811991, 1573501X
Catalysis
Organic Chemistry
Drug Discovery
Inorganic Chemistry
Physical and Theoretical Chemistry
Molecular Biology
General Medicine
Information Systems
Abstract
A library of hybrid molecules bearing thioglycoluril and (hetero)aromatic aldehyde thiosemicarbazone moieties was synthesized via a tandem hydrazone formation—ring contraction reaction of 5,7-dialkyl-3-thioxoperhydroimidazo[4,5-e]-1,2,4-triazin-6-ones with (hetero)aromatic aldehydes. All synthesized compounds were tested for their cytotoxic activity against rhabdomyosarcoma, A549, and MS human cancer cell lines by MTT-assay. Among the derivatives, (E)-4-benzylideneamino-1,3-dimethyl-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-one 1f was found to have the most marked antiproliferative activity toward the tested cell lines (1f: IC$$_{50}= 20.6,$$50=20.6, 23.7, and 6.4 $$\upmu $$μM, respectively). The IC$$_{50}$$50 value of thioglycoluril 1f against normal human embryonic kidney cells HEK293 was 72.5 $$\upmu $$μM, which appeared to be 3–11-fold higher than IC$$_{50}$$50 values of 1f against human cancer cells.

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GOST Copy
Gazieva G. A. et al. Substituted N-aminothioglycolurils containing thiosemicarbazone moiety and their cytotoxic activity in vitro // Molecular Diversity. 2016. Vol. 20. No. 4. pp. 837-846.
GOST all authors (up to 50) Copy
Gazieva G. A., Anikina L. V., Pukhov S. A., Karpova T. B., Nelyubina Y. V., Kravchenko A. N. Substituted N-aminothioglycolurils containing thiosemicarbazone moiety and their cytotoxic activity in vitro // Molecular Diversity. 2016. Vol. 20. No. 4. pp. 837-846.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s11030-016-9671-1
UR - https://doi.org/10.1007%2Fs11030-016-9671-1
TI - Substituted N-aminothioglycolurils containing thiosemicarbazone moiety and their cytotoxic activity in vitro
T2 - Molecular Diversity
AU - Anikina, Lada V
AU - Pukhov, Sergei A
AU - Karpova, Tatyana B
AU - Nelyubina, Yulia V.
AU - Gazieva, Galina A
AU - Kravchenko, Angelina N
PY - 2016
DA - 2016/05/23 00:00:00
PB - Springer Nature
SP - 837-846
IS - 4
VL - 20
SN - 1381-1991
SN - 1573-501X
ER -
BibTex |
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BibTex Copy
@article{2016_Gazieva
author = {Lada V Anikina and Sergei A Pukhov and Tatyana B Karpova and Yulia V. Nelyubina and Galina A Gazieva and Angelina N Kravchenko},
title = {Substituted N-aminothioglycolurils containing thiosemicarbazone moiety and their cytotoxic activity in vitro},
journal = {Molecular Diversity},
year = {2016},
volume = {20},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007%2Fs11030-016-9671-1},
number = {4},
pages = {837--846},
doi = {10.1007/s11030-016-9671-1}
}
MLA
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MLA Copy
Gazieva, Galina A., et al. “Substituted N-aminothioglycolurils containing thiosemicarbazone moiety and their cytotoxic activity in vitro.” Molecular Diversity, vol. 20, no. 4, May. 2016, pp. 837-846. https://doi.org/10.1007%2Fs11030-016-9671-1.
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