ChemMedChem, volume 12, issue 9, pages 622-638

Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs

Fershtat Leonid L. ¹

Makhova Nina N. ¹

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N. D. Zelinsky Institute of Organic Chemistry; Russian Academy of Sciences; Leninsky Prosp. 47 Moscow 119991 Russian Federation |

Publication type: Journal Article

Publication date: 2017-04-12

Wiley

Journal: ChemMedChem

Quartile SCImago

Quartile WOS

Impact factor: 3.4

ISSN: 18607179, 18607187

DOI: 10.1002/cmdc.201700113

Copy DOI

Organic Chemistry

Drug Discovery

Biochemistry

Pharmacology

Molecular Medicine

General Pharmacology, Toxicology and Pharmaceutics

Abstract

The molecular hybridization of different compounds with known pharmacological activity is a particularly prominent approach for the design of potential drugs with improved pharmacokinetic profiles. Much attention over the last decade has been focused on the synthesis of hybrid structures with a nitric oxide (NO)‐donor framework, as NO is a ubiquitous and crucial regulator of cellular metabolism, affecting various physiological and pathophysiological processes. 1,2,5‐Oxadiazole 2‐oxides (furoxans), which are capable of exogenous NO release in the presence of thiol cofactors, are an important class of prospective NO donors. As such, a wide range of hybrid compounds that combine a furoxan ring with various pharmacologically active structures have been created. This review focuses on recent results in the synthesis and pharmacological activity of furoxan‐based hybrids. Special attention is given to chemo‐ and regioselective methods used in the preparation of these hybrid structures, and the role of synergistic effects on their pharmacological activity, associated with the furoxan fragment.

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Citations by journals

	1 2 3 4 5 6 7 8 9
Mendeleev Communications	Mendeleev Communications, 9, 11.11% Mendeleev Communications 9 publications, 11.11%
Tetrahedron Letters	Tetrahedron Letters, 6, 7.41% Tetrahedron Letters 6 publications, 7.41%
Russian Chemical Bulletin	Russian Chemical Bulletin, 5, 6.17% Russian Chemical Bulletin 5 publications, 6.17%
Molecules	Molecules, 5, 6.17% Molecules 5 publications, 6.17%
Journal of Organic Chemistry	Journal of Organic Chemistry, 4, 4.94% Journal of Organic Chemistry 4 publications, 4.94%
Journal of Molecular Structure	Journal of Molecular Structure, 4, 4.94% Journal of Molecular Structure 4 publications, 4.94%
Synthesis	Synthesis, 4, 4.94% Synthesis 4 publications, 4.94%
European Journal of Organic Chemistry	European Journal of Organic Chemistry, 2, 2.47% European Journal of Organic Chemistry 2 publications, 2.47%
Tetrahedron	Tetrahedron, 2, 2.47% Tetrahedron 2 publications, 2.47%
MolBank	MolBank, 2, 2.47% MolBank 2 publications, 2.47%
Pharmaceuticals	Pharmaceuticals, 2, 2.47% Pharmaceuticals 2 publications, 2.47%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 1.23% Chemistry - A European Journal 1 publication, 1.23%
Chemistry of Heterocyclic Compounds	Chemistry of Heterocyclic Compounds, 1, 1.23% Chemistry of Heterocyclic Compounds 1 publication, 1.23%
Advanced Synthesis and Catalysis	Advanced Synthesis and Catalysis, 1, 1.23% Advanced Synthesis and Catalysis 1 publication, 1.23%
ChemPhotoChem	ChemPhotoChem, 1, 1.23% ChemPhotoChem 1 publication, 1.23%
Chemical Biology and Drug Design	Chemical Biology and Drug Design, 1, 1.23% Chemical Biology and Drug Design 1 publication, 1.23%
Asian Journal of Organic Chemistry	Asian Journal of Organic Chemistry, 1, 1.23% Asian Journal of Organic Chemistry 1 publication, 1.23%
Current Organic Chemistry	Current Organic Chemistry, 1, 1.23% Current Organic Chemistry 1 publication, 1.23%
Molecular Diversity	Molecular Diversity, 1, 1.23% Molecular Diversity 1 publication, 1.23%
Green Synthesis and Catalysis	Green Synthesis and Catalysis, 1, 1.23% Green Synthesis and Catalysis 1 publication, 1.23%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 1.23% Russian Chemical Reviews 1 publication, 1.23%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 1, 1.23% European Journal of Medicinal Chemistry 1 publication, 1.23%
Nitric Oxide - Biology and Chemistry	Nitric Oxide - Biology and Chemistry, 1, 1.23% Nitric Oxide - Biology and Chemistry 1 publication, 1.23%
ChemMedChem	ChemMedChem, 1, 1.23% ChemMedChem 1 publication, 1.23%
Journal of the Chinese Chemical Society	Journal of the Chinese Chemical Society, 1, 1.23% Journal of the Chinese Chemical Society 1 publication, 1.23%
Chemistry - An Asian Journal	Chemistry - An Asian Journal, 1, 1.23% Chemistry - An Asian Journal 1 publication, 1.23%
Journal of Heterocyclic Chemistry	Journal of Heterocyclic Chemistry, 1, 1.23% Journal of Heterocyclic Chemistry 1 publication, 1.23%
ACS Infectious Diseases	ACS Infectious Diseases, 1, 1.23% ACS Infectious Diseases 1 publication, 1.23%
Journal of the American Chemical Society	Journal of the American Chemical Society, 1, 1.23% Journal of the American Chemical Society 1 publication, 1.23%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 1, 1.23% Journal of Medicinal Chemistry 1 publication, 1.23%
	1 2 3 4 5 6 7 8 9

Citations by publishers

	5 10 15 20 25
Elsevier	Elsevier, 25, 30.86% Elsevier 25 publications, 30.86%
Wiley	Wiley, 11, 13.58% Wiley 11 publications, 13.58%
American Chemical Society (ACS)	American Chemical Society (ACS), 10, 12.35% American Chemical Society (ACS) 10 publications, 12.35%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 9, 11.11% Multidisciplinary Digital Publishing Institute (MDPI) 9 publications, 11.11%
Springer Nature	Springer Nature, 7, 8.64% Springer Nature 7 publications, 8.64%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 7.41% Royal Society of Chemistry (RSC) 6 publications, 7.41%
Thieme	Thieme, 5, 6.17% Thieme 5 publications, 6.17%
Taylor & Francis	Taylor & Francis, 3, 3.7% Taylor & Francis 3 publications, 3.7%
Bentham Science	Bentham Science, 2, 2.47% Bentham Science 2 publications, 2.47%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 1.23% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 1.23%
Society of Synthetic Organic Chemistry	Society of Synthetic Organic Chemistry, 1, 1.23% Society of Synthetic Organic Chemistry 1 publication, 1.23%
The Japan Institute of Heterocyclic Chemistry	The Japan Institute of Heterocyclic Chemistry, 1, 1.23% The Japan Institute of Heterocyclic Chemistry 1 publication, 1.23%
	5 10 15 20 25

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Fershtat L. L., Makhova N. N. Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs // ChemMedChem. 2017. Vol. 12. No. 9. pp. 622-638.

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Fershtat L. L., Makhova N. N. Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs // ChemMedChem. 2017. Vol. 12. No. 9. pp. 622-638.

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TY - JOUR

DO - 10.1002/cmdc.201700113

UR - https://doi.org/10.1002%2Fcmdc.201700113

TI - Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs

T2 - ChemMedChem

AU - Fershtat, Leonid L.

AU - Makhova, Nina N.

PY - 2017

DA - 2017/04/12 00:00:00

PB - Wiley

SP - 622-638

IS - 9

VL - 12

SN - 1860-7179

SN - 1860-7187

ER -

BibTex |

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@article{2017_Fershtat,

author = {Leonid L. Fershtat and Nina N. Makhova},

title = {Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs},

journal = {ChemMedChem},

year = {2017},

volume = {12},

publisher = {Wiley},

month = {apr},

url = {https://doi.org/10.1002%2Fcmdc.201700113},

number = {9},

pages = {622--638},

doi = {10.1002/cmdc.201700113}

}

MLA

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Fershtat, Leonid L., and Nina N. Makhova. “Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs.” ChemMedChem, vol. 12, no. 9, Apr. 2017, pp. 622-638. https://doi.org/10.1002%2Fcmdc.201700113.

Found error?

Publisher

Wiley

Journal

ChemMedChem

Quartile SCImago

Quartile WOS

Impact factor

3.4

ISSN

18607179 (Print)
18607187 (Electronic)

Labs

Laboratory of Nitrogen-Containing Compounds

Profiles

Fershtat, Leonid L