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Journal of Pharmaceutical Analysis, volume 11, issue 2, pages 241-250

Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert

Wang Ting 1
Li Feina 1
Lu Qinpei 1
Wu Gang 1
Jiang Zhongke 1
Liu Shaowei 1
Habden Xugela 2
Osterman Ilya A 4, 5
Sergiev Petr V. 4, 5
Dontsova Olga A. 4, 5, 6
Hu Xinxin 1
You Xue-Fu 1
Publication typeJournal Article
Publication date2021-04-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor8.8
ISSN20951779
Drug Discovery
Spectroscopy
Pharmaceutical Science
Analytical Chemistry
Electrochemistry
Pharmacy
Abstract
Three hundred and twenty endophytic actinobacterial strains were isolated from psammophytes collected from Taklamakan Desert and identified. Among them, three strains already had been identified as new species of two genera and sixteen isolates showed relatively low 16S rRNA similarities < 98.6% to validly described species. Seventy-five of the isolates were selected as representative strains to screen antibacterial activity and mechanism. Forty-seven strains showed antagonistic activity against at least one of the indicator bacteria. Two Streptomyces strains produced bioactive compounds inducing DNA damage, and two Streptomyces strains produced bioactive compounds with inhibitory activity on protein biosynthesis. Notably, the strain Streptomyces sp. 8P21H-1 that demonstrated both strong antibacterial activity and inhibitory activity on protein biosynthesis was prioritized for exploring new antibiotics. Under the strategy of integrating genetics-based discovery program and MS/MS-based molecular networking, two new streptogramin-type antibiotics, i.e., acetyl-griseoviridin and desulphurizing griseoviridin, along with known griseoviridin, were isolated from the culture broth of strain 8P21H-1. Their chemical structures were determined by HR-MS, and 1D and 2D NMR. Desulphurizing griseoviridin and griseoviridin exhibited antibacterial activities by inhibiting translation. • Integrated analytic technologies break the bottleneck of metabolites rediscovery. • Two new streptogramin-type antibiotics were discovered from Streptomyces sp. 8P21H-1. • Actinobacteria from Taklamakan are promising source of novel species and compounds.

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GOST Copy
Wang T. et al. Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert // Journal of Pharmaceutical Analysis. 2021. Vol. 11. No. 2. pp. 241-250.
GOST all authors (up to 50) Copy
Wang T., Li F., Lu Q., Wu G., Jiang Z., Liu S., Habden X., Razumova E. A., Osterman I. A., Sergiev P. V., Dontsova O. A., Hu X., You X., Sun C. Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert // Journal of Pharmaceutical Analysis. 2021. Vol. 11. No. 2. pp. 241-250.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.jpha.2020.06.004
UR - https://doi.org/10.1016%2Fj.jpha.2020.06.004
TI - Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert
T2 - Journal of Pharmaceutical Analysis
AU - Wang, Ting
AU - Li, Feina
AU - Lu, Qinpei
AU - Wu, Gang
AU - Jiang, Zhongke
AU - Liu, Shaowei
AU - Habden, Xugela
AU - Razumova, Elizaveta A
AU - Osterman, Ilya A
AU - Sergiev, Petr V.
AU - Dontsova, Olga A.
AU - Hu, Xinxin
AU - You, Xue-Fu
AU - Sun, Chenghang
PY - 2021
DA - 2021/04/01 00:00:00
PB - Xi'an Jiaotong University
SP - 241-250
IS - 2
VL - 11
PMID - 34012700
SN - 2095-1779
ER -
BibTex |
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BibTex Copy
@article{2021_Wang
author = {Ting Wang and Feina Li and Qinpei Lu and Gang Wu and Zhongke Jiang and Shaowei Liu and Xugela Habden and Elizaveta A Razumova and Ilya A Osterman and Petr V. Sergiev and Olga A. Dontsova and Xinxin Hu and Xue-Fu You and Chenghang Sun},
title = {Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert},
journal = {Journal of Pharmaceutical Analysis},
year = {2021},
volume = {11},
publisher = {Xi'an Jiaotong University},
month = {apr},
url = {https://doi.org/10.1016%2Fj.jpha.2020.06.004},
number = {2},
pages = {241--250},
doi = {10.1016/j.jpha.2020.06.004}
}
MLA
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MLA Copy
Wang, Ting, et al. “Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert.” Journal of Pharmaceutical Analysis, vol. 11, no. 2, Apr. 2021, pp. 241-250. https://doi.org/10.1016%2Fj.jpha.2020.06.004.
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