Biochemistry (Moscow), volume 86, issue S1, pages S24-S37
Metallo-β-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition
Levina Elena O
1
,
Khrenova Maria G
1, 2
1
Publication type: Journal Article
Publication date: 2021-01-01
Journal:
Biochemistry (Moscow)
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.8
ISSN: 00062979, 16083040
Biochemistry
General Medicine
Abstract
The review focuses on bacterial metallo-β-lactamases (MβLs) responsible for the inactivation of β-lactams and associated antibiotic resistance. The diversity of the active site structure in the members of different MβL subclasses explains different mechanisms of antibiotic hydrolysis and should be taken into account when searching for potential MβL inhibitors. The review describes the features of the antibiotic inactivation mechanisms by various MβLs studied by X-ray crystallography, NMR, kinetic measurements, and molecular modeling. The mechanisms of enzyme inhibition for each MβL subclass are discussed.
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Molecules
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Molecules
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 100%
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Levina E. O., Khrenova M. G. Metallo-β-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition // Biochemistry (Moscow). 2021. Vol. 86. No. S1. p. S24-S37.
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Levina E. O., Khrenova M. G. Metallo-β-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition // Biochemistry (Moscow). 2021. Vol. 86. No. S1. p. S24-S37.
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TY - JOUR
DO - 10.1134/S0006297921140030
UR - https://doi.org/10.1134%2FS0006297921140030
TI - Metallo-β-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition
T2 - Biochemistry (Moscow)
AU - Khrenova, Maria G
AU - Levina, Elena O
PY - 2021
DA - 2021/01/01 00:00:00
PB - Pleiades Publishing
SP - S24-S37
IS - S1
VL - 86
SN - 0006-2979
SN - 1608-3040
ER -
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@article{2021_Levina,
author = {Maria G Khrenova and Elena O Levina},
title = {Metallo-β-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition},
journal = {Biochemistry (Moscow)},
year = {2021},
volume = {86},
publisher = {Pleiades Publishing},
month = {jan},
url = {https://doi.org/10.1134%2FS0006297921140030},
number = {S1},
pages = {S24--S37},
doi = {10.1134/S0006297921140030}
}
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Levina, Elena O., et al. “Metallo-β-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition.” Biochemistry (Moscow), vol. 86, no. S1, Jan. 2021, pp. S24-S37. https://doi.org/10.1134%2FS0006297921140030.
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