Russian Journal of Physical Chemistry A, volume 93, issue 10, pages 1873-1879

Reconstructing the Electron Density of Intermediates of the Hydrolysis of N-Acetylaspartate by Aspartoacylase

Publication typeJournal Article
Publication date2019-09-24
Quartile SCImago
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Quartile WOS
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Impact factor0.7
ISSN00360244, 1531863X
Physical and Theoretical Chemistry
Abstract
The hydrolysis of N-acetylaspartate by human aspartoacylase shows that using promolecular electron density (superpositions of the densities of spherical atoms) is insufficient for describing intermediates of reactions of enzyme catalysis. The deformation of electron density caused by the formation of covalent and coordination bonds inside a system must be considered, creating the need to develop new approaches in protein crystallography for better interpretation of observed electron density and more precise determination of the geometrical parameters of reaction intermediates.
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Khrenova M. G. et al. Reconstructing the Electron Density of Intermediates of the Hydrolysis of N-Acetylaspartate by Aspartoacylase // Russian Journal of Physical Chemistry A. 2019. Vol. 93. No. 10. pp. 1873-1879.
GOST all authors (up to 50) Copy
Khrenova M. G., Kots E. D., Kulakova A. M., Nemukhin A. V. Reconstructing the Electron Density of Intermediates of the Hydrolysis of N-Acetylaspartate by Aspartoacylase // Russian Journal of Physical Chemistry A. 2019. Vol. 93. No. 10. pp. 1873-1879.
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TY - JOUR
DO - 10.1134/S003602441910011X
UR - https://doi.org/10.1134%2FS003602441910011X
TI - Reconstructing the Electron Density of Intermediates of the Hydrolysis of N-Acetylaspartate by Aspartoacylase
T2 - Russian Journal of Physical Chemistry A
AU - Khrenova, M. G.
AU - Kots, E D
AU - Kulakova, A M
AU - Nemukhin, A. V.
PY - 2019
DA - 2019/09/24 00:00:00
PB - Pleiades Publishing
SP - 1873-1879
IS - 10
VL - 93
SN - 0036-0244
SN - 1531-863X
ER -
BibTex |
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@article{2019_Khrenova
author = {M. G. Khrenova and E D Kots and A M Kulakova and A. V. Nemukhin},
title = {Reconstructing the Electron Density of Intermediates of the Hydrolysis of N-Acetylaspartate by Aspartoacylase},
journal = {Russian Journal of Physical Chemistry A},
year = {2019},
volume = {93},
publisher = {Pleiades Publishing},
month = {sep},
url = {https://doi.org/10.1134%2FS003602441910011X},
number = {10},
pages = {1873--1879},
doi = {10.1134/S003602441910011X}
}
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Khrenova, M. G., et al. “Reconstructing the Electron Density of Intermediates of the Hydrolysis of N-Acetylaspartate by Aspartoacylase.” Russian Journal of Physical Chemistry A, vol. 93, no. 10, Sep. 2019, pp. 1873-1879. https://doi.org/10.1134%2FS003602441910011X.
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