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Scientific Reports, volume 4, issue 1, publication number 3845

Separation of photo-induced radical pair in cryptochrome to a functionally critical distance

SOLOV'YOV ILIA A. ^{1, 2}

Domratcheva Tatiana ³

Schulten Klaus ^{1, 4}

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Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, USA |

Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense M, Denmark |

Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Heidelberg, Germany |

⁴

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, USA |

Publication type: Journal Article

Publication date: 2014-01-24

Springer Nature

Journal: Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor: 4.6

ISSN: 20452322

DOI: 10.1038/srep03845

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PubMed ID: 24457842

Multidisciplinary

Abstract

Cryptochrome is a blue light receptor that acts as a sensor for the geomagnetic field and assists many animals in long-range navigation. The magnetoreceptor function arises from light-induced formation of a radical pair through electron transfer between a flavin cofactor (FAD) and a triad of tryptophan residues. Here, this electron transfer is investigated by quantum chemical and classical molecular dynamics calculations. The results reveal how sequential electron transfer, assisted by rearrangement of polar side groups in the cryptochrome interior, can yield a FAD-Trp radical pair state with the FAD and Trp partners separated beyond a critical distance. The large radical pair separation reached establishes cryptochrome's sensitivity to the geomagnetic field through weakening of distance-dependent exchange and dipole-dipole interactions. It is estimated that the key secondary electron transfer step can overcome in speed both recombination (electron back-transfer) and proton transfer involving the radical pair reached after primary electron transfer.

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Journal of the American Chemical Society	Journal of the American Chemical Society, 5, 8.2% Journal of the American Chemical Society 5 publications, 8.2%
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Journal of Physical Chemistry B	Journal of Physical Chemistry B, 4, 6.56% Journal of Physical Chemistry B 4 publications, 6.56%
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Physical Review E	Physical Review E, 2, 3.28% Physical Review E 2 publications, 3.28%
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PLoS ONE	PLoS ONE, 2, 3.28% PLoS ONE 2 publications, 3.28%
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Biochemistry	Biochemistry, 2, 3.28% Biochemistry 2 publications, 3.28%
Journal of Chemical Information and Modeling	Journal of Chemical Information and Modeling, 2, 3.28% Journal of Chemical Information and Modeling 2 publications, 3.28%
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Communications Chemistry	Communications Chemistry, 1, 1.64% Communications Chemistry 1 publication, 1.64%
Nature	Nature, 1, 1.64% Nature 1 publication, 1.64%
Nature Chemical Biology	Nature Chemical Biology, 1, 1.64% Nature Chemical Biology 1 publication, 1.64%
Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology	Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology, 1, 1.64% Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology 1 publication, 1.64%
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Citations by publishers

	2 4 6 8 10 12 14 16
American Chemical Society (ACS)	American Chemical Society (ACS), 16, 26.23% American Chemical Society (ACS) 16 publications, 26.23%
Springer Nature	Springer Nature, 8, 13.11% Springer Nature 8 publications, 13.11%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 8, 13.11% Royal Society of Chemistry (RSC) 8 publications, 13.11%
Wiley	Wiley, 4, 6.56% Wiley 4 publications, 6.56%
American Physical Society (APS)	American Physical Society (APS), 3, 4.92% American Physical Society (APS) 3 publications, 4.92%
Elsevier	Elsevier, 3, 4.92% Elsevier 3 publications, 4.92%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 2, 3.28% American Institute of Physics (AIP) 2 publications, 3.28%
The Royal Society	The Royal Society, 2, 3.28% The Royal Society 2 publications, 3.28%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 2, 3.28% Multidisciplinary Digital Publishing Institute (MDPI) 2 publications, 3.28%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 3.28% Public Library of Science (PLoS) 2 publications, 3.28%
Biophysical Society	Biophysical Society, 2, 3.28% Biophysical Society 2 publications, 3.28%
Annual Reviews	Annual Reviews, 2, 3.28% Annual Reviews 2 publications, 3.28%
Frontiers Media S.A.	Frontiers Media S.A., 1, 1.64% Frontiers Media S.A. 1 publication, 1.64%
IOP Publishing	IOP Publishing, 1, 1.64% IOP Publishing 1 publication, 1.64%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 1, 1.64% Proceedings of the National Academy of Sciences (PNAS) 1 publication, 1.64%
	2 4 6 8 10 12 14 16

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SOLOV'YOV I. A. et al. Separation of photo-induced radical pair in cryptochrome to a functionally critical distance // Scientific Reports. 2014. Vol. 4. No. 1. 3845

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SOLOV'YOV I. A., Domratcheva T., Schulten K. Separation of photo-induced radical pair in cryptochrome to a functionally critical distance // Scientific Reports. 2014. Vol. 4. No. 1. 3845

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TY - JOUR

DO - 10.1038/srep03845

UR - https://doi.org/10.1038%2Fsrep03845

TI - Separation of photo-induced radical pair in cryptochrome to a functionally critical distance

T2 - Scientific Reports

AU - Domratcheva, Tatiana

AU - Schulten, Klaus

AU - SOLOV'YOV, ILIA A.

PY - 2014

DA - 2014/01/24 00:00:00

PB - Springer Nature

IS - 1

VL - 4

PMID - 24457842

SN - 2045-2322

ER -

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@article{2014_SOLOV'YOV,

author = {Tatiana Domratcheva and Klaus Schulten and ILIA A. SOLOV'YOV},

title = {Separation of photo-induced radical pair in cryptochrome to a functionally critical distance},

journal = {Scientific Reports},

year = {2014},

volume = {4},

publisher = {Springer Nature},

month = {jan},

url = {https://doi.org/10.1038%2Fsrep03845},

number = {1},

doi = {10.1038/srep03845}

}

Found error?

Publisher

Springer Nature

Journal

Scientific Reports

Quartile SCImago

Quartile WOS

Impact factor

4.6

ISSN

20452322 (Print)

Profiles

Domratcheva, T