Open Access
Molecules, volume 26, issue 18, pages 5705
Recent advances in the synthesis and biomedical applications of heterocyclic no-donors
Publication type: Journal Article
Publication date: 2021-09-21
PubMed ID:
34577175
Organic Chemistry
Drug Discovery
Physical and Theoretical Chemistry
Pharmaceutical Science
Molecular Medicine
Analytical Chemistry
Chemistry (miscellaneous)
Abstract
Nitric oxide (NO) is a key signaling molecule that acts in various physiological processes such as cellular metabolism, vasodilation and transmission of nerve impulses. A wide number of vascular diseases as well as various immune and neurodegenerative disorders were found to be directly associated with a disruption of NO production in living organisms. These issues justify a constant search of novel NO-donors with improved pharmacokinetic profiles and prolonged action. In a series of known structural classes capable of NO release, heterocyclic NO-donors are of special importance due to their increased hydrolytic stability and low toxicity. It is no wonder that synthetic and biochemical investigations of heterocyclic NO-donors have emerged significantly in recent years. In this review, we summarized recent advances in the synthesis, reactivity and biomedical applications of promising heterocyclic NO-donors (furoxans, sydnone imines, pyridazine dioxides, azasydnones). The synthetic potential of each heterocyclic system along with biochemical mechanisms of action are emphasized.
Citations by journals
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3
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Russian Chemical Bulletin
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Russian Chemical Bulletin
3 publications, 15%
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MolBank
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MolBank
2 publications, 10%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 5%
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Journal of Molecular Structure
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Journal of Molecular Structure
1 publication, 5%
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Angewandte Chemie - International Edition
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Angewandte Chemie - International Edition
1 publication, 5%
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Angewandte Chemie
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Angewandte Chemie
1 publication, 5%
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ACS applied materials & interfaces
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ACS applied materials & interfaces
1 publication, 5%
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New Journal of Chemistry
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New Journal of Chemistry
1 publication, 5%
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Agrochemicals
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Agrochemicals
1 publication, 5%
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Green Chemistry
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Green Chemistry
1 publication, 5%
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ACS Omega
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ACS Omega
1 publication, 5%
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Advances in Heterocyclic Chemistry
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Advances in Heterocyclic Chemistry
1 publication, 5%
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Molecules
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Molecules
1 publication, 5%
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RSC Medicinal Chemistry
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RSC Medicinal Chemistry
1 publication, 5%
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Mendeleev Communications
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Mendeleev Communications
1 publication, 5%
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Journal of Organometallic Chemistry
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Journal of Organometallic Chemistry
1 publication, 5%
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Stresses
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Stresses
1 publication, 5%
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1
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3
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Citations by publishers
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6
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
6 publications, 30%
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Elsevier
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Elsevier
4 publications, 20%
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Springer Nature
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Springer Nature
3 publications, 15%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
3 publications, 15%
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Wiley
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Wiley
2 publications, 10%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
2 publications, 10%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Fershtat L. L., Zhilin E. S. Recent advances in the synthesis and biomedical applications of heterocyclic no-donors // Molecules. 2021. Vol. 26. No. 18. p. 5705.
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Fershtat L. L., Zhilin E. S. Recent advances in the synthesis and biomedical applications of heterocyclic no-donors // Molecules. 2021. Vol. 26. No. 18. p. 5705.
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TY - JOUR
DO - 10.3390/molecules26185705
UR - https://doi.org/10.3390%2Fmolecules26185705
TI - Recent advances in the synthesis and biomedical applications of heterocyclic no-donors
T2 - Molecules
AU - Fershtat, Leonid L
AU - Zhilin, Egor S
PY - 2021
DA - 2021/09/21 00:00:00
PB - Multidisciplinary Digital Publishing Institute (MDPI)
SP - 5705
IS - 18
VL - 26
PMID - 34577175
SN - 1420-3049
ER -
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@article{2021_Fershtat,
author = {Leonid L Fershtat and Egor S Zhilin},
title = {Recent advances in the synthesis and biomedical applications of heterocyclic no-donors},
journal = {Molecules},
year = {2021},
volume = {26},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
month = {sep},
url = {https://doi.org/10.3390%2Fmolecules26185705},
number = {18},
pages = {5705},
doi = {10.3390/molecules26185705}
}
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Fershtat, Leonid L., and Egor S Zhilin. “Recent advances in the synthesis and biomedical applications of heterocyclic no-donors.” Molecules, vol. 26, no. 18, Sep. 2021, p. 5705. https://doi.org/10.3390%2Fmolecules26185705.