Open Access

International Journal of Molecular Sciences, volume 22, issue 8, pages 3817

Pt(Iv) prodrugs with nsaids as axial ligands

Spector Daniil ^{1, 2}

Krasnovskaya Olga O. ^{1, 2}

Pavlov Kirill G. ²

Erofeev Alexander ^{1, 2}

Gorelkin Peter ^{1, 2}

Beloglazkina Elena ²

Majouga Alexander ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Materials Science of Semiconductors and Dielectrics, National University of Science and Technology (MISIS), Leninskiy Prospect 4, 101000 Moscow, Russia |

Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1,3, 119991 Moscow, Russia |

Mendeleev University of Chemical Technology of Russia, Miusskaya Ploshchad’ 9, 125047 Moscow, Russia |

Publication type: Journal Article

Publication date: 2021-04-07

Multidisciplinary Digital Publishing Institute (MDPI)

Journal: International Journal of Molecular Sciences

Quartile SCImago

Quartile WOS

Impact factor: 5.6

ISSN: 16616596, 14220067

DOI: 10.3390/ijms22083817

Copy DOI

PubMed ID: 33917027

Catalysis

Organic Chemistry

Inorganic Chemistry

Physical and Theoretical Chemistry

Computer Science Applications

Spectroscopy

Molecular Biology

General Medicine

Abstract

A chemo-anti-inflammatory strategy is of interest for the treatment of aggressive cancers. The platinum (IV) prodrug with non-steroidal anti-inflammatory drugs (NSAIDs) as axial ligands is designed to efficiently enter tumor cells due to high lipophilicity and release the cytotoxic metabolite and NSAID intracellularly, thereby reducing side effects and increasing the therapeutic efficacy of platinum chemotherapy. Over the last 7 years, a number of publications have been devoted to the design of such Pt(IV) prodrugs in combination with anti-inflammatory chemotherapy, with high therapeutic efficacy in vitro and In vivo. In this review, we summarize the studies devoted to the development of Pt(IV) prodrugs with NSAIDs as axial ligands, the study of the mechanism of their cytotoxic action and anti-inflammatory activity, the structure–activity ratio, and therapeutic efficacy.

By date By citations

Citations by journals

	1 2 3 4 5 6
Dalton Transactions	Dalton Transactions, 6, 17.14% Dalton Transactions 6 publications, 17.14%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 4, 11.43% Journal of Medicinal Chemistry 4 publications, 11.43%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 3, 8.57% International Journal of Molecular Sciences 3 publications, 8.57%
Pharmaceutics	Pharmaceutics, 3, 8.57% Pharmaceutics 3 publications, 8.57%
Inorganics	Inorganics, 2, 5.71% Inorganics 2 publications, 5.71%
Molecules	Molecules, 2, 5.71% Molecules 2 publications, 5.71%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 2, 5.71% European Journal of Medicinal Chemistry 2 publications, 5.71%
Analytical Chemistry	Analytical Chemistry, 1, 2.86% Analytical Chemistry 1 publication, 2.86%
ACS applied materials & interfaces	ACS applied materials & interfaces, 1, 2.86% ACS applied materials & interfaces 1 publication, 2.86%
Cancers	Cancers, 1, 2.86% Cancers 1 publication, 2.86%
ChemPhysChem	ChemPhysChem, 1, 2.86% ChemPhysChem 1 publication, 2.86%
International Journal of Nanomedicine	International Journal of Nanomedicine, 1, 2.86% International Journal of Nanomedicine 1 publication, 2.86%
Cancer Chemotherapy and Pharmacology	Cancer Chemotherapy and Pharmacology, 1, 2.86% Cancer Chemotherapy and Pharmacology 1 publication, 2.86%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 2.86% Chemistry - A European Journal 1 publication, 2.86%
Russian Chemical Bulletin	Russian Chemical Bulletin, 1, 2.86% Russian Chemical Bulletin 1 publication, 2.86%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 2.86% Russian Chemical Reviews 1 publication, 2.86%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 1, 2.86% Applied Sciences (Switzerland) 1 publication, 2.86%
Coordination Chemistry Reviews	Coordination Chemistry Reviews, 1, 2.86% Coordination Chemistry Reviews 1 publication, 2.86%
New Journal of Chemistry	New Journal of Chemistry, 1, 2.86% New Journal of Chemistry 1 publication, 2.86%
Journal of Molecular Structure	Journal of Molecular Structure, 1, 2.86% Journal of Molecular Structure 1 publication, 2.86%
	1 2 3 4 5 6

Citations by publishers

	2 4 6 8 10 12
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 12, 34.29% Multidisciplinary Digital Publishing Institute (MDPI) 12 publications, 34.29%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 7, 20% Royal Society of Chemistry (RSC) 7 publications, 20%
American Chemical Society (ACS)	American Chemical Society (ACS), 6, 17.14% American Chemical Society (ACS) 6 publications, 17.14%
Elsevier	Elsevier, 4, 11.43% Elsevier 4 publications, 11.43%
Wiley	Wiley, 2, 5.71% Wiley 2 publications, 5.71%
Springer Nature	Springer Nature, 2, 5.71% Springer Nature 2 publications, 5.71%
Dove Medical Press	Dove Medical Press, 1, 2.86% Dove Medical Press 1 publication, 2.86%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 2.86% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 2.86%
	2 4 6 8 10 12

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[3,9,19,4],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["8.57","25.71","54.29","11.43"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Dalton Transactions","Journal of Medicinal Chemistry","International Journal of Molecular Sciences","Pharmaceutics","Inorganics","Molecules","European Journal of Medicinal Chemistry","Analytical Chemistry","ACS applied materials & interfaces","Cancers","ChemPhysChem","International Journal of Nanomedicine","Cancer Chemotherapy and Pharmacology","Chemistry - A European Journal","Russian Chemical Bulletin","Russian Chemical Reviews","Applied Sciences (Switzerland)","Coordination Chemistry Reviews","New Journal of Chemistry","Journal of Molecular Structure"],"ids":[8473,3673,14627,4502,4005,1770,8171,18157,1458,22471,16306,10956,17457,24708,10918,23802,16650,13437,1404,9347],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[6,4,3,3,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[17.14,11.43,8.57,8.57,5.71,5.71,5.71,2.86,2.86,2.86,2.86,2.86,2.86,2.86,2.86,2.86,2.86,2.86,2.86,2.86],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Royal Society of Chemistry (RSC)","American Chemical Society (ACS)","Elsevier","Wiley","Springer Nature","Dove Medical Press","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii"],"ids":[202,123,40,17,11,8,417,9422],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/wVWp6zaxUsMdR03dYMdOZoesUrVGtNMWkHKByIvT_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp"],"datasets":[{"label":"","data":[12,7,6,4,2,2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[34.29,20,17.14,11.43,5.71,5.71,2.86,2.86],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Publication PDF

Metrics

Cite this

GOST |

Cite this

GOST Copy

Spector D. et al. Pt(Iv) prodrugs with nsaids as axial ligands // International Journal of Molecular Sciences. 2021. Vol. 22. No. 8. p. 3817.

GOST all authors (up to 50) Copy

Spector D., Krasnovskaya O. O., Pavlov K. G., Erofeev A., Gorelkin P., Beloglazkina E., Majouga A. Pt(Iv) prodrugs with nsaids as axial ligands // International Journal of Molecular Sciences. 2021. Vol. 22. No. 8. p. 3817.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.3390/ijms22083817

UR - https://doi.org/10.3390%2Fijms22083817

TI - Pt(Iv) prodrugs with nsaids as axial ligands

T2 - International Journal of Molecular Sciences

AU - Erofeev, Alexander

AU - Beloglazkina, Elena

AU - Majouga, Alexander

AU - Spector, Daniil

AU - Krasnovskaya, Olga O.

AU - Pavlov, Kirill G.

AU - Gorelkin, Peter

PY - 2021

DA - 2021/04/07 00:00:00

PB - Multidisciplinary Digital Publishing Institute (MDPI)

SP - 3817

IS - 8

VL - 22

PMID - 33917027

SN - 1661-6596

SN - 1422-0067

ER -

BibTex |

Cite this

BibTex Copy

@article{2021_Spector,

author = {Alexander Erofeev and Elena Beloglazkina and Alexander Majouga and Daniil Spector and Olga O. Krasnovskaya and Kirill G. Pavlov and Peter Gorelkin},

title = {Pt(Iv) prodrugs with nsaids as axial ligands},

journal = {International Journal of Molecular Sciences},

year = {2021},

volume = {22},

publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},

month = {apr},

url = {https://doi.org/10.3390%2Fijms22083817},

number = {8},

pages = {3817},

doi = {10.3390/ijms22083817}

}

MLA

Cite this

MLA Copy

Spector, Daniil, et al. “Pt(Iv) prodrugs with nsaids as axial ligands.” International Journal of Molecular Sciences, vol. 22, no. 8, Apr. 2021, p. 3817. https://doi.org/10.3390%2Fijms22083817.

Found error?

Publisher

Multidisciplinary Digital Publishing Institute (MDPI)

Journal

International Journal of Molecular Sciences

Quartile SCImago

Quartile WOS

Impact factor

5.6

ISSN

16616596 (Print)
14220067 (Electronic)

Labs

Laboratory of Biologically Active Organic Compounds (BAOС)

Profiles