ChemMedChem, volume 14, issue 4, pages 454-461
Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
Asquith Christopher R M
1, 2, 3
,
Laitinen Tuomo
4
,
Konstantinova Lidia S.
5, 6
,
Tizzard G. J.
7
,
Poso Antti
4
,
Rakitin Oleg A.
5, 6
,
3
Current address: Department of PharmacologySchool of MedicineUniversity of North Carolina at Chapel Hill 120 Mason Farm Road, Genetic Medicine Building Chapel Hill NC 27599 USA
|
5
Publication type: Journal Article
Publication date: 2019-01-25
Journal:
ChemMedChem
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.4
ISSN: 18607179, 18607187
Organic Chemistry
Drug Discovery
Biochemistry
Pharmacology
Molecular Medicine
General Pharmacology, Toxicology and Pharmaceutics
Abstract
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
Citations by journals
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1
2
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Bioorganic and Medicinal Chemistry
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Bioorganic and Medicinal Chemistry
2 publications, 22.22%
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Antibiotics
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Antibiotics
1 publication, 11.11%
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Current Topics in Medicinal Chemistry
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Current Topics in Medicinal Chemistry
1 publication, 11.11%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 11.11%
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Pathogens
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Pathogens
1 publication, 11.11%
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Russian Chemical Reviews
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Russian Chemical Reviews
1 publication, 11.11%
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Progress in Heterocyclic Chemistry
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Progress in Heterocyclic Chemistry
1 publication, 11.11%
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Molecules
|
Molecules
1 publication, 11.11%
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|
1
2
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Citations by publishers
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1
2
3
4
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 44.44%
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Elsevier
|
Elsevier
3 publications, 33.33%
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|
Bentham Science
|
Bentham Science
1 publication, 11.11%
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|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 11.11%
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1
2
3
4
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Asquith C. R. M. et al. Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection // ChemMedChem. 2019. Vol. 14. No. 4. pp. 454-461.
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Asquith C. R. M., Laitinen T., Konstantinova L. S., Tizzard G. J., Poso A., Rakitin O. A., Hofmann-Lehmann R., HILTON S. Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection // ChemMedChem. 2019. Vol. 14. No. 4. pp. 454-461.
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TY - JOUR
DO - 10.1002/cmdc.201800718
UR - https://doi.org/10.1002%2Fcmdc.201800718
TI - Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
T2 - ChemMedChem
AU - Konstantinova, Lidia S.
AU - Asquith, Christopher R M
AU - Laitinen, Tuomo
AU - Poso, Antti
AU - Rakitin, Oleg A.
AU - Hofmann-Lehmann, Regina
AU - HILTON, STEPHEN
AU - Tizzard, G. J.
PY - 2019
DA - 2019/01/25 00:00:00
PB - Wiley
SP - 454-461
IS - 4
VL - 14
SN - 1860-7179
SN - 1860-7187
ER -
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@article{2019_Asquith,
author = {Lidia S. Konstantinova and Christopher R M Asquith and Tuomo Laitinen and Antti Poso and Oleg A. Rakitin and Regina Hofmann-Lehmann and STEPHEN HILTON and G. J. Tizzard},
title = {Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection},
journal = {ChemMedChem},
year = {2019},
volume = {14},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1002%2Fcmdc.201800718},
number = {4},
pages = {454--461},
doi = {10.1002/cmdc.201800718}
}
Cite this
MLA
Copy
Asquith, Christopher R. M., et al. “Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection.” ChemMedChem, vol. 14, no. 4, Jan. 2019, pp. 454-461. https://doi.org/10.1002%2Fcmdc.201800718.