International Journal of Biological Macromolecules, volume 164, pages 1451-1460
Biodegradable thermoresponsive oligochitosan nanoparticles: Mechanisms of phase transition and drug binding-release
Burova Tatiana V
1
,
Plashchina Irina G
2
,
Tikhonov Vladimir E
1
,
Orlov Victor N.
3
,
Grinberg Natalia V
,
Grinberg Natalia V
1
,
Dubovik Alexander S
,
Manucha Walter
4
,
Khokhlov Alexei R.
5, 6
4
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782-Santiago de Compostela, Spain.
|
Publication type: Journal Article
Publication date: 2020-12-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 8.2
ISSN: 01418130, 18790003
Biochemistry
Molecular Biology
General Medicine
Structural Biology
Abstract
Oligochitosan, a low molecular weight derivative of the cationic biopolymer, chitosan, currently shows a great potential of application as a biodegradable non-toxic stimuli-sensitive drug carrier. This paper aimed to elucidate the thermoresponsive potential of oligochitosan and the temperature-controlled drug binding and release to shed light on oligochitosan potential in stimuli-responsive drug delivery. Mechanisms of thermoresponsive behavior of oligochitosan induced by β-glycerophosphate (GP) were investigated using ITC, DSC, and DLS. Upon heating, the aqueous oligochitosan solution underwent a cooperative transition of the microphase separation type resulting in the formation of stable nano-sized particles. Energetics of the GP-oligochitosan interaction (evaluated by ITC) revealed a positive enthalpy of the GP binding to oligochitosan, which pointed to a notable contribution of dehydration and the related rearrangement of the polysaccharide hydration shell. Energetics of the thermal phase transition of oligochitosan was investigated by DSC upon variation of the solvent dielectric constant and GP concentration. The dependences of the transition parameters on these variables were determined and used for the analysis of the oligochitosan thermoresponsivity mechanism. The binding of ibuprofen to the thermotropic oligochitosan nanogel particles and its release from them were evaluated under near-physiological conditions. Relevantly, the oligochitosan nanoparticles surpassed some reference macromolecular adsorbers by the affinity for the drug and by the delayed release kinetics.
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Burova T. V. et al. Biodegradable thermoresponsive oligochitosan nanoparticles: Mechanisms of phase transition and drug binding-release // International Journal of Biological Macromolecules. 2020. Vol. 164. pp. 1451-1460.
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Burova T. V., Grinberg V. Y., Grinberg N. V., S. Dubovik A., Tikhonov V. E., Orlov V., Plashchina I. G., Alvarez‐Lorenzo C., Khokhlov A. R., Grinberg N. V., Dubovik A. S., Manucha W., Khokhlov A. R. Biodegradable thermoresponsive oligochitosan nanoparticles: Mechanisms of phase transition and drug binding-release // International Journal of Biological Macromolecules. 2020. Vol. 164. pp. 1451-1460.
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TY - JOUR
DO - 10.1016/j.ijbiomac.2020.07.203
UR - https://doi.org/10.1016%2Fj.ijbiomac.2020.07.203
TI - Biodegradable thermoresponsive oligochitosan nanoparticles: Mechanisms of phase transition and drug binding-release
T2 - International Journal of Biological Macromolecules
AU - Burova, Tatiana V
AU - Grinberg, Valerij Y
AU - Grinberg, Natalia V
AU - S. Dubovik, Alexander
AU - Tikhonov, Vladimir E
AU - Orlov, Victor N.
AU - Plashchina, Irina G
AU - Alvarez‐Lorenzo, Carmen
AU - Khokhlov, Alexei R.
AU - Manucha, Walter
AU - Grinberg, Natalia V
AU - Dubovik, Alexander S
AU - Khokhlov, Alexei R.
PY - 2020
DA - 2020/12/01 00:00:00
PB - Elsevier
SP - 1451-1460
VL - 164
SN - 0141-8130
SN - 1879-0003
ER -
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@article{2020_Burova,
author = {Tatiana V Burova and Valerij Y Grinberg and Natalia V Grinberg and Alexander S. Dubovik and Vladimir E Tikhonov and Victor N. Orlov and Irina G Plashchina and Carmen Alvarez‐Lorenzo and Alexei R. Khokhlov and Walter Manucha and Natalia V Grinberg and Alexander S Dubovik and Alexei R. Khokhlov},
title = {Biodegradable thermoresponsive oligochitosan nanoparticles: Mechanisms of phase transition and drug binding-release},
journal = {International Journal of Biological Macromolecules},
year = {2020},
volume = {164},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.ijbiomac.2020.07.203},
pages = {1451--1460},
doi = {10.1016/j.ijbiomac.2020.07.203}
}
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