Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells

Pukhov S.A., Anikina L.A., Larin A.A., Fershtat L.L., Kulikov A.S., Makhova N.N.
Тип документаJournal Article
Дата публикации2019-01-01
Название журналаRussian Chemical Bulletin
ИздательSpringer Nature
КвартильQ3
ISSN10665285, 15739171
  • General Chemistry
Краткое описание
Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis(1,2,4-oxadiazol- 3-yl)furoxan (2), and 4-amino-3-(indenotriazin-3-yl)furoxan (3)) exhibit in vitro cytotoxic activity against chronic myeloid leukemia K562 cells. All studied furoxans induce apoptosis in K562 cells. The experiments with activation of caspases-3 and -7 showed that furoxan 3 possessed the highest apoptosis-inducing capacity. The studied hetarylfuroxans were found to be the promising drug candidates for the treatment of chronic myeloid leukemia K562.
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1. Pukhov S.A. и др. Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells // Russian Chemical Bulletin. 2019. Т. 68. № 1. С. 158–162.
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TY - JOUR

DO - 10.1007/s11172-019-2431-5

UR - http://dx.doi.org/10.1007/s11172-019-2431-5

TI - Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells

T2 - Russian Chemical Bulletin

AU - Pukhov, S. A.

AU - Anikina, L. A.

AU - Larin, A. A.

AU - Fershtat, L. L.

AU - Kulikov, A. S.

AU - Makhova, N. N.

PY - 2019

DA - 2019/01

PB - Springer Science and Business Media LLC

SP - 158-162

IS - 1

VL - 68

SN - 1066-5285

SN - 1573-9171

ER -

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@article{2019,

doi = {10.1007/s11172-019-2431-5},

url = {https://doi.org/10.1007%2Fs11172-019-2431-5},

year = 2019,

month = {jan},

publisher = {Springer Science and Business Media {LLC}},

volume = {68},

number = {1},

pages = {158--162},

author = {S. A. Pukhov and L. A. Anikina and A. A. Larin and L. L. Fershtat and A. S. Kulikov and N. N. Makhova},

title = {Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells}

}

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Pukhov, S. A. et al. “Hetarylfuroxans: Cytotoxic Effect and Induction of Apoptosis in Chronic Myeloid Leukemia K562 Cells.” Russian Chemical Bulletin 68.1 (2019): 158–162. Crossref. Web.