Russian Chemical Bulletin, volume 68, issue 1, pages 158-162
Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells
Publication type: Journal Article
Publication date: 2019-01-01
Journal:
Russian Chemical Bulletin
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 1.7
ISSN: 10665285, 15739171
General Chemistry
Abstract
Hetarylfuroxans (4-(2-methylpyridin-5-yloxy)-3-phenylfuroxan (1), bis(1,2,4-oxadiazol- 3-yl)furoxan (2), and 4-amino-3-(indenotriazin-3-yl)furoxan (3)) exhibit in vitro cytotoxic activity against chronic myeloid leukemia K562 cells. All studied furoxans induce apoptosis in K562 cells. The experiments with activation of caspases-3 and -7 showed that furoxan 3 possessed the highest apoptosis-inducing capacity. The studied hetarylfuroxans were found to be the promising drug candidates for the treatment of chronic myeloid leukemia K562.
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Citations by publishers
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Wiley
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4 publications, 44.44%
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Elsevier
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2 publications, 22.22%
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Springer Nature
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1 publication, 11.11%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Pukhov S. A. et al. Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells // Russian Chemical Bulletin. 2019. Vol. 68. No. 1. pp. 158-162.
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Pukhov S. A., Anikina L. A., Larin A. A., Fershtat L. L., Kulikov A., Makhova N. N. Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells // Russian Chemical Bulletin. 2019. Vol. 68. No. 1. pp. 158-162.
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TY - JOUR
DO - 10.1007/s11172-019-2431-5
UR - https://doi.org/10.1007%2Fs11172-019-2431-5
TI - Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells
T2 - Russian Chemical Bulletin
AU - Pukhov, S A
AU - Anikina, L A
AU - Larin, A A
AU - Fershtat, L L
AU - Kulikov, A.S
AU - Makhova, N N
PY - 2019
DA - 2019/01/01 00:00:00
PB - Springer Nature
SP - 158-162
IS - 1
VL - 68
SN - 1066-5285
SN - 1573-9171
ER -
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@article{2019_Pukhov,
author = {S A Pukhov and L A Anikina and A A Larin and L L Fershtat and A.S Kulikov and N N Makhova},
title = {Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells},
journal = {Russian Chemical Bulletin},
year = {2019},
volume = {68},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1007%2Fs11172-019-2431-5},
number = {1},
pages = {158--162},
doi = {10.1007/s11172-019-2431-5}
}
Cite this
MLA
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Pukhov, S. A., et al. “Hetarylfuroxans: cytotoxic effect and induction of apoptosis in chronic myeloid leukemia K562 cells.” Russian Chemical Bulletin, vol. 68, no. 1, Jan. 2019, pp. 158-162. https://doi.org/10.1007%2Fs11172-019-2431-5.