Bioorganic and Medicinal Chemistry Letters, volume 29, issue 14, pages 1765-1768
Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection
Meili Theres
2
,
Baranovsky Ilia V
3
,
Konstantinova Lidia S.
3, 4
,
Poso Antti
3
,
Rakitin Oleg A.
3, 4
,
1
Department of Pharmacology, School of Medicine University of North Carolina at Chapel Hill, NC 27599, USA
|
Publication type: Journal Article
Publication date: 2019-07-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.7
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
We report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV.
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Citations by publishers
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3
4
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8
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8 publications, 33.33%
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7 publications, 29.17%
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2 publications, 8.33%
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1 publication, 4.17%
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1 publication, 4.17%
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Royal Society of Chemistry (RSC)
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1 publication, 4.17%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 4.17%
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Taylor & Francis
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Taylor & Francis
1 publication, 4.17%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Asquith C. R. M. et al. Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 14. pp. 1765-1768.
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Asquith C. R. M., Meili T., Baranovsky I. V., Konstantinova L. S., Poso A., Rakitin O. A., Hofmann-Lehmann R. Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 14. pp. 1765-1768.
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TY - JOUR
DO - 10.1016/j.bmcl.2019.05.016
UR - https://doi.org/10.1016%2Fj.bmcl.2019.05.016
TI - Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Asquith, Christopher R M
AU - Meili, Theres
AU - Rakitin, Oleg A.
AU - Baranovsky, Ilia V
AU - Konstantinova, Lidia S.
AU - Poso, Antti
AU - Hofmann-Lehmann, Regina
PY - 2019
DA - 2019/07/01 00:00:00
PB - Elsevier
SP - 1765-1768
IS - 14
VL - 29
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2019_Asquith,
author = {Christopher R M Asquith and Theres Meili and Oleg A. Rakitin and Ilia V Baranovsky and Lidia S. Konstantinova and Antti Poso and Regina Hofmann-Lehmann},
title = {Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2019},
volume = {29},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016%2Fj.bmcl.2019.05.016},
number = {14},
pages = {1765--1768},
doi = {10.1016/j.bmcl.2019.05.016}
}
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MLA
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Asquith, Christopher R. M., et al. “Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection.” Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 14, Jul. 2019, pp. 1765-1768. https://doi.org/10.1016%2Fj.bmcl.2019.05.016.