Materials Science and Engineering C, volume 104, pages 109924
The first inorganic mitogens: Cerium oxide and cerium fluoride nanoparticles stimulate planarian regeneration via neoblastic activation
Ermakov Artem M.
1
,
Popov Anton L.
1
,
Ermakova Olga P.
1
,
Ivanova Olga E
2
,
Baranchikov Alexander E
2, 3
,
Kamenskikh Kristina
1
,
Istomin Sergey Ya.
2, 3
,
Popova Nelli
1
,
Ivanov V. V.
2, 3
4
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine,Kyiv D0368,Ukraine
|
Publication type: Journal Article
Publication date: 2019-11-01
Journal:
Materials Science and Engineering C
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.9
ISSN: 09284931, 18730191
Bioengineering
Biomaterials
Mechanics of Materials
Abstract
We report the first experimental evidence for the mitogenic action of cerium(IV) oxide and cerium(III) fluoride nanoparticles (CONs and CFNs) on the regeneration of a whole organism - freshwater flatworms Schmidtea mediterranea (planarian). Both types of cerium-containing nanoparticles are shown to be a highly potent mitogen for planaria. Both CONs and CFNs, in micro- and nanomolar concentrations, markedly accelerate planarian blastema growth, due to the enhancement of cellular proliferation, causing an increase in the mitotic index and in the quantity of blastema cells in regenerating planaria. CONs provided maximum activity at concentrations which were two orders of magnitude lower than those for CeF3. The valence state of cerium in cerium-containing nanoparticles plays a significant role in the planarian regeneration mechanism: CeO2 nanoparticles containing predominantly Ce4+ species presumably scavenge wound induced reactive oxygen species and moderately activate gene expression processes, while the regenerative action of CeF3 nanoparticles containing only Ce3+ species is manifested in the pronounced expression of the genes involved in cell division, differentiation and migration. This is the first report on the effect of cerium-containing nanoparticles on tissue regeneration in vivo, further revealing the mechanisms of their biological action, which enhances the possibility of their use in cellular technologies.
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1
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Citations by publishers
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2
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6
8
10
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10 publications, 47.62%
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Elsevier
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1 publication, 4.76%
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Wiley
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1 publication, 4.76%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 4.76%
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Trans Tech Publications
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1 publication, 4.76%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 4.76%
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2
4
6
8
10
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ermakov A. M. et al. The first inorganic mitogens: Cerium oxide and cerium fluoride nanoparticles stimulate planarian regeneration via neoblastic activation // Materials Science and Engineering C. 2019. Vol. 104. p. 109924.
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Ermakov A. M., Popov A. L., Ermakova O. P., Ivanova O. E., Baranchikov A. E., Kamenskikh K., Istomin S. Y., Shcherbakov A. B., Popova N., Ivanov V. V. The first inorganic mitogens: Cerium oxide and cerium fluoride nanoparticles stimulate planarian regeneration via neoblastic activation // Materials Science and Engineering C. 2019. Vol. 104. p. 109924.
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TY - JOUR
DO - 10.1016/j.msec.2019.109924
UR - https://doi.org/10.1016%2Fj.msec.2019.109924
TI - The first inorganic mitogens: Cerium oxide and cerium fluoride nanoparticles stimulate planarian regeneration via neoblastic activation
T2 - Materials Science and Engineering C
AU - Ermakov, Artem M.
AU - Popov, Anton L.
AU - Ermakova, Olga P.
AU - Ivanova, Olga E
AU - Baranchikov, Alexander E
AU - Kamenskikh, Kristina
AU - Istomin, Sergey Ya.
AU - Shcherbakov, Alexander B.
AU - Popova, Nelli
AU - Ivanov, V. V.
PY - 2019
DA - 2019/11/01 00:00:00
PB - Elsevier
SP - 109924
VL - 104
SN - 0928-4931
SN - 1873-0191
ER -
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@article{2019_Ermakov,
author = {Artem M. Ermakov and Anton L. Popov and Olga P. Ermakova and Olga E Ivanova and Alexander E Baranchikov and Kristina Kamenskikh and Sergey Ya. Istomin and Alexander B. Shcherbakov and Nelli Popova and V. V. Ivanov},
title = {The first inorganic mitogens: Cerium oxide and cerium fluoride nanoparticles stimulate planarian regeneration via neoblastic activation},
journal = {Materials Science and Engineering C},
year = {2019},
volume = {104},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016%2Fj.msec.2019.109924},
pages = {109924},
doi = {10.1016/j.msec.2019.109924}
}