Arseny V Rybakov
About
My current main project focuses on the development of a novel antimicrobial peptide.
In E. coli, the protein EF-Tu, in complex with GTP, delivers tRNA to the ribosome during translation. Following codon-anticodon interaction, GTP is hydrolyzed to GDP, rendering EF-Tu inactive and leading to its dissociation from the ribosome. The reactivation of EF-Tu requires EF-Ts, which binds to EF-Tu and induces a conformational change. This change facilitates the dissociation of GDP, which is then replaced by GTP due to the approximately 100-fold higher concentration of GTP compared to GDP in the cytoplasm.
The goal of this project is to create novel antimicrobial peptides which will disrupt the formation of the EF-Tu•EF-Ts complex. This project integrates multiple approaches, including molecular modeling, protein expression and purification, functional activity validation, and biophysical investigation of interactions among EF-Tu, EF-Ts, and the synthesized modeled peptides.
Research interests
Education
Top-100
Fields of science
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Biochemistry
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Biochemistry, 2, 40%
Biochemistry
2 publications, 40%
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Physiology
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Physiology, 2, 40%
Physiology
2 publications, 40%
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Ecology, Evolution, Behavior and Systematics
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Ecology, Evolution, Behavior and Systematics, 2, 40%
Ecology, Evolution, Behavior and Systematics
2 publications, 40%
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General Biochemistry, Genetics and Molecular Biology
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General Biochemistry, Genetics and Molecular Biology, 1, 20%
General Biochemistry, Genetics and Molecular Biology
1 publication, 20%
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Medicine (miscellaneous)
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Medicine (miscellaneous), 1, 20%
Medicine (miscellaneous)
1 publication, 20%
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General Medicine
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General Medicine, 1, 20%
General Medicine
1 publication, 20%
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Journals
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Journal of Evolutionary Biochemistry and Physiology
2 publications, 40%
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Current Rheumatology Reviews
1 publication, 20%
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Biomedicines
1 publication, 20%
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Medical academic journal
1 publication, 20%
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2
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Citing journals
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1
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Current Opinion in Rheumatology
1 citation, 25%
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Clinical Rheumatology
1 citation, 25%
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International Journal of Molecular Sciences
1 citation, 25%
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APMIS
1 citation, 25%
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1
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Publishers
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2
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Pleiades Publishing
2 publications, 40%
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Bentham Science Publishers Ltd.
1 publication, 20%
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MDPI
1 publication, 20%
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Eco-Vector LLC
1 publication, 20%
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2
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Organizations from articles
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5
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Peter the Great St. Petersburg Polytechnic University
5 publications, 100%
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I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences
5 publications, 100%
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Saint Petersburg State University
4 publications, 80%
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Almazov National Medical Research Centre
4 publications, 80%
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Saint Petersburg State Pediatric Medical University
2 publications, 40%
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Pitirim Sorokin Syktyvkar State University
2 publications, 40%
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Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech
1 publication, 20%
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Countries from articles
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Russia
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Russia, 5, 100%
Russia
5 publications, 100%
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Country not defined
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Country not defined, 2, 40%
Country not defined
2 publications, 40%
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5
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Citing organizations
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2
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Organization not defined
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Organization not defined, 2, 50%
Organization not defined
2 citations, 50%
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University of Oulu
1 citation, 25%
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University of Turku
1 citation, 25%
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Turku University Hospital
1 citation, 25%
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Universidad Andrés Bello
1 citation, 25%
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Universidad de Santiago de Chile
1 citation, 25%
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Universidad Metropolitana de Ciencias de la Educación
1 citation, 25%
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2
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Citing countries
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2
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Country not defined
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Country not defined, 2, 50%
Country not defined
2 citations, 50%
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Finland
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Finland, 2, 50%
Finland
2 citations, 50%
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France
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France, 1, 25%
France
1 citation, 25%
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Chile
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Chile, 1, 25%
Chile
1 citation, 25%
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1
2
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- We do not take into account publications without a DOI.
- Statistics recalculated daily.