,
volume 1867
,
issue 2
,
pages 159082
Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues
Eva Cífková
1
,
Radana Karlíková
2
,
Magdaléna Ovčačíková
1
,
Dana Dobešová
2
,
Kateřina Mičová
2
,
Aleš Kvasnička
2
,
Zuzana Vaňková
1
,
Jiří Šiller
3
,
Lukáš Sákra
3
,
David Friedecký
2
,
Michal Holčapek
1
3
Regional Hospital Pardubice, Surgery Clinic, Kyjevská 44, 53203 Pardubice, Czech Republic
|
Publication type: Journal Article
Publication date: 2022-02-01
scimago Q2
wos Q2
SJR: 1.212
CiteScore: 8.6
Impact factor: 3.3
ISSN: 13881981, 18792618
PubMed ID:
34793969
Molecular Biology
Cell Biology
Abstract
Lung cancer represents one of the leading worldwide causes of cancer death, but the pathobiochemistry of this disease is still not fully understood. Here we characterize the lipidomic and metabolomic profiles of the tumor and surrounding normal tissues for 23 patients with non-small cell lung cancer. In total, 500 molecular species were identified and quantified by a combination of the lipidomic shotgun tandem mass spectrometry (MS/MS) analysis and the targeted metabolomic approach using liquid chromatography (LC) - MS/MS. The statistical evaluation includes multivariate and univariate methods with the emphasis on paired statistical approaches. Our research revealed significant changes in several biochemical pathways related to the central carbon metabolism, acylcarnitines, dipeptides as well as the disruption in the lipid metabolism observed mainly for glycerophospholipids, sphingolipids, and cholesteryl esters.
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Total citations:
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Citations from 2024:
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(50%)
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Cífková E. et al. Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues // Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2022. Vol. 1867. No. 2. p. 159082.
GOST all authors (up to 50)
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Cífková E., Karlíková R., Ovčačíková M., Dobešová D., Mičová K., Kvasnička A., Vaňková Z., Šiller J., Sákra L., Friedecký D., Holčapek M. Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues // Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2022. Vol. 1867. No. 2. p. 159082.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bbalip.2021.159082
UR - https://doi.org/10.1016/j.bbalip.2021.159082
TI - Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues
T2 - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
AU - Cífková, Eva
AU - Karlíková, Radana
AU - Ovčačíková, Magdaléna
AU - Dobešová, Dana
AU - Mičová, Kateřina
AU - Kvasnička, Aleš
AU - Vaňková, Zuzana
AU - Šiller, Jiří
AU - Sákra, Lukáš
AU - Friedecký, David
AU - Holčapek, Michal
PY - 2022
DA - 2022/02/01
PB - Elsevier
SP - 159082
IS - 2
VL - 1867
PMID - 34793969
SN - 1388-1981
SN - 1879-2618
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Cífková,
author = {Eva Cífková and Radana Karlíková and Magdaléna Ovčačíková and Dana Dobešová and Kateřina Mičová and Aleš Kvasnička and Zuzana Vaňková and Jiří Šiller and Lukáš Sákra and David Friedecký and Michal Holčapek},
title = {Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues},
journal = {Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids},
year = {2022},
volume = {1867},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bbalip.2021.159082},
number = {2},
pages = {159082},
doi = {10.1016/j.bbalip.2021.159082}
}
Cite this
MLA
Copy
Cífková, Eva, et al. “Lipidomic and metabolomic analysis reveals changes in biochemical pathways for non-small cell lung cancer tissues.” Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1867, no. 2, Feb. 2022, p. 159082. https://doi.org/10.1016/j.bbalip.2021.159082.