Trends in Cancer

, volume 9 , issue 12 , pages 1058-1068

Variant of allele frequency: a decision-making tool in precision oncology?

Luca Boscolo Bielo ^{1, 2}

Dario Trapani ^{1, 2}

Matteo Repetto ^{1, 2, 3}

Edoardo Crimini ^{1, 2}

Carmine Valenza ^{1, 2}

C. Belli ²

Carmen Criscitiello ^{1, 2}

Antonio Marra ²

Vivek Subbiah ⁴

Giuseppe Curigliano ^{1, 2}

Hide authors affiliations Show authors affiliations: 4 affiliations

Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy |

Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Milan, Italy

Istituti di Ricovero e Cura a Carattere Scientifico

European Institute of Oncology

Early Drug Development service, Memorial Sloan-Kettering Cancer Center, New York, USA |

⁴

Drug Development Unit, Sarah Cannon Research Institute, Nashville, TN, USA |

Publication type: Journal Article

Publication date: 2023-12-01

Elsevier

Trends in Cancer

scimago Q1

wos Q1

SJR: 4.727

CiteScore: 25.5

Impact factor: 17.5

ISSN: 24058033, 24058025

DOI: 10.1016/j.trecan.2023.08.011

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PubMed ID: 37704501

Cancer Research

Oncology

Abstract

Precision oncology requires additional predictive biomarkers for targeted therapy selection. Variant allele frequency (VAF), measuring the proportion of variant alleles within a genomic locus, provides insights into tumor clonality in somatic genomic testing, yielding a strong rationale for targeting dominant cancer cell populations. The prognostic and predictive roles of VAF have been evaluated across different studies. Yet, the absence of validated VAF thresholds and a lack of standardization between sequencing assays currently hampers its clinical utility. Therefore, analytical and clinical validation must be further examined. This Review summarizes the evidence regarding the use of VAF as a predictive biomarker and discusses challenges and opportunities for its clinical implementation as a decision-making tool for targeted therapy selection.

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Boscolo Bielo L. et al. Variant of allele frequency: a decision-making tool in precision oncology? // Trends in Cancer. 2023. Vol. 9. No. 12. pp. 1058-1068.

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Boscolo Bielo L., Trapani D., Repetto M., Crimini E., Valenza C., Belli C., Criscitiello C., Marra A., Subbiah V., Curigliano G. Variant of allele frequency: a decision-making tool in precision oncology? // Trends in Cancer. 2023. Vol. 9. No. 12. pp. 1058-1068.

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