The ERBB network: at last, cancer therapy meets systems biology
Publication type: Journal Article
Publication date: 2012-07-12
scimago Q1
wos Q1
SJR: 24.378
CiteScore: 103.8
Impact factor: 66.8
ISSN: 1474175X, 14741768
DOI:
10.1038/nrc3309
PubMed ID:
22785351
General Environmental Science
General Earth and Planetary Sciences
Abstract
This Timeline article focuses on the ERBB network of receptor tyrosine kinases, which exemplifies how a constant dialogue between basic and clinical cancer research can lead to the development of both novel drugs and strategies to overcome acquired resistance. Although it is broadly agreed that the improved treatment of patients with cancer will depend on a deeper molecular understanding of the underlying pathogenesis, only a few examples are already available. This Timeline article focuses on the ERBB (also known as HER) network of receptor tyrosine kinases (RTKs), which exemplifies how a constant dialogue between basic research and medical oncology can translate into both a sustained pipeline of novel drugs and ways to overcome acquired treatment resistance in patients. We track the key early discoveries that linked this RTK family to oncogenesis, the course of pioneering clinical research and their merger into a systems-biology framework that is likely to inspire further generations of effective therapeutic strategies.
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Metrics
828
Total citations:
828
Citations from 2024:
127
(15.35%)
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GOST
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Yarden Y., Pines G. The ERBB network: at last, cancer therapy meets systems biology // Nature Reviews Cancer. 2012. Vol. 12. No. 8. pp. 553-563.
GOST all authors (up to 50)
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Yarden Y., Pines G. The ERBB network: at last, cancer therapy meets systems biology // Nature Reviews Cancer. 2012. Vol. 12. No. 8. pp. 553-563.
Cite this
RIS
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TY - JOUR
DO - 10.1038/nrc3309
UR - https://doi.org/10.1038/nrc3309
TI - The ERBB network: at last, cancer therapy meets systems biology
T2 - Nature Reviews Cancer
AU - Yarden, Yosef
AU - Pines, Gur
PY - 2012
DA - 2012/07/12
PB - Springer Nature
SP - 553-563
IS - 8
VL - 12
PMID - 22785351
SN - 1474-175X
SN - 1474-1768
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Yarden,
author = {Yosef Yarden and Gur Pines},
title = {The ERBB network: at last, cancer therapy meets systems biology},
journal = {Nature Reviews Cancer},
year = {2012},
volume = {12},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1038/nrc3309},
number = {8},
pages = {553--563},
doi = {10.1038/nrc3309}
}
Cite this
MLA
Copy
Yarden, Yosef, and Gur Pines. “The ERBB network: at last, cancer therapy meets systems biology.” Nature Reviews Cancer, vol. 12, no. 8, Jul. 2012, pp. 553-563. https://doi.org/10.1038/nrc3309.