Open Access
Open access
Oxford University Press
Oncologist

Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study

Fernando Sabino Marques Monteiro 1, 2, 3
, 
Antonio Machado Alencar Junior 1, 4
, 
Karine Martins Da Trindade 1, 5
, 
Taiane Francieli Rebelatto 1
, 
Fernando C Maluf 1, 6
, 
Antonia A Gazzola 3
, 
Pablo M. Barrios 1
, 
Joaquim Bellmunt 7
, 
Rafaela Gomes De Jesus 1
, 
Gyl Eanes Barros Silva 4
, 
Antonio Augusto Lima Teixeira Junior 8
, 
Philippe E. Spiess 9
, 
Andre P Fay 1, 3, 10
1
 
Latin American Cooperative Oncology Group (LACOG) , Porto Alegre , Brazil | 
2
 
3
 
4
 
5
 
Instituto de Ensino e Pesquisa do Ceará , Fortaleza , Brazil | 
6
 
Hospital Israelita Albert Einstein, Oncology and Hematology Department ,  São Paulo , Brazil | 
7
 
8
 
Postgraduate Program in Genetics, Ribeirão Preto Medical School, Universisty of São Paulo , Ribeirão Preto , Brazil | 
9
 
10
 
Hospital Nora Teixeira, Oncology and Hematology Department ,  Porto Alegre , Brazil | 
Publication type: Journal Article
Publication date: 2024-09-02
Oxford University Press
scimago Q1
wos Q2
SJR: 2.329
CiteScore: 9.2
Impact factor: 4.2
ISSN: 10837159, 1549490X
Abstract
Background

Penile squamous cell carcinoma (PSCC) is a rare malignancy. However, in developing countries the incidence rate is higher. The understanding of molecular alterations is essential for evaluating possible targets for more effective systemic therapies.

Methods

We retrospectively collected clinical data of metastatic PSCC (mPSCC) patients who had received at least one prior systemic treatment from 3 Brazilian hospitals. Tumor samples were evaluated using the next-generation sequencing (NGS) Foundation One DX and immunohistochemistry (IHC). The objective was to identify and describe somatic genomic alterations known to be functional or pathogenic and their association with survival outcomes.

Results

Twenty-three patients were identified, 22 and 18 patients had tumor samples analyzed by IHC and NGS, respectively. PD-L1 expression (CPS ≥ 1%) was positive in 14 patients (63.6%). Regarding the genomic alterations, 16 patients (88.9%) had some clinically relevant genomic alterations. TP53, TERT, CDKN2A, PIK3CA, NOTCH1, and CDKN2B loss were identified in 66.7%, 50%, 50%, 33.3%, 27.8%, and 22.2% of the patients, respectively. No MSI or TMB high (≥10 mutations/MB) cases were identified. NOTCH1 mutation was identified only in HPV-negative patients and it was associated with worse OS (yes: 5.5 vs no: 12.8 months, P = .049) and progression-free survival (yes: 5.5 vs no: 11.7 months, P = .032).

Conclusion

This study demonstrated that molecular alterations in mPSCC from developing countries are similar to those from developed countries. Predictive biomarkers for immunotherapy response such as TMB high or MSI were not identified. Specific gene mutations may identify patients with worse prognoses and open new avenues for therapeutic development.

Found 
Found 

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GOST Copy
Marques Monteiro F. S. et al. Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study // Oncologist. 2024.
GOST all authors (up to 50) Copy
Marques Monteiro F. S., Alencar Junior A. M., Da Trindade K. M., Rebelatto T. F., Maluf F. C., Gazzola A. A., Barrios P. M., Bellmunt J., De Jesus R. G., Silva G. E. B., Teixeira Junior A. A. L., Spiess P. E., Fay A. P. Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study // Oncologist. 2024.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1093/oncolo/oyae220
UR - https://academic.oup.com/oncolo/advance-article/doi/10.1093/oncolo/oyae220/7747924
TI - Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study
T2 - Oncologist
AU - Marques Monteiro, Fernando Sabino
AU - Alencar Junior, Antonio Machado
AU - Da Trindade, Karine Martins
AU - Rebelatto, Taiane Francieli
AU - Maluf, Fernando C
AU - Gazzola, Antonia A
AU - Barrios, Pablo M.
AU - Bellmunt, Joaquim
AU - De Jesus, Rafaela Gomes
AU - Silva, Gyl Eanes Barros
AU - Teixeira Junior, Antonio Augusto Lima
AU - Spiess, Philippe E.
AU - Fay, Andre P
PY - 2024
DA - 2024/09/02
PB - Oxford University Press
PMID - 39222919
SN - 1083-7159
SN - 1549-490X
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Marques Monteiro,
author = {Fernando Sabino Marques Monteiro and Antonio Machado Alencar Junior and Karine Martins Da Trindade and Taiane Francieli Rebelatto and Fernando C Maluf and Antonia A Gazzola and Pablo M. Barrios and Joaquim Bellmunt and Rafaela Gomes De Jesus and Gyl Eanes Barros Silva and Antonio Augusto Lima Teixeira Junior and Philippe E. Spiess and Andre P Fay},
title = {Molecular characterization of metastatic penile squamous cell carcinoma in developing countries and its impact on clinical outcomes: LACOG 2018 translational study},
journal = {Oncologist},
year = {2024},
publisher = {Oxford University Press},
month = {sep},
url = {https://academic.oup.com/oncolo/advance-article/doi/10.1093/oncolo/oyae220/7747924},
doi = {10.1093/oncolo/oyae220}
}