Otolaryngology - Head and Neck Surgery

, volume 157 , issue 1 , pages 16-24

Predictive Value of GJB2 Mutation Status for Hearing Outcomes of Pediatric Cochlear Implantation

Yasin Abdurehim ^{1, 2}

Alexandre Lehmann ^{1, 3}

Anthony Zeitouni ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Otolaryngology–Head and Neck Surgery, McGill University, Montreal, Canada |

Department of Otolaryngology, First Teaching Hospital of Xinjiang Medical University, Urumqi, China |

Centre for Research on Brain, Music and Language, Montreal, Canada |

Publication type: Journal Article

Publication date: 2017-03-21

SAGE

Otolaryngology - Head and Neck Surgery

scimago Q1

wos Q1

SJR: 0.987

CiteScore: 4.8

Impact factor: 2.5

ISSN: 01945998, 10976817

DOI: 10.1177/0194599817697054

Copy DOI

PubMed ID: 28322114

Surgery

Otorhinolaryngology

Abstract

Objective

To systematically review and quantify current evidence regarding the association of GJB2 mutation status with outcomes of pediatric cochlear implantation.

Data Sources

PubMed, Embase, and the Cochrane Library were searched for “GJB2,”“pediatric hearing loss,” and “cochlear implantation” and their synonyms, with no language restrictions, until December 2, 2015.

Review Methods

Studies were included that investigated the status of GJB2 mutation and its predictive value for outcomes of pediatric cochlear implantation. Speech recognition scores, Infant-Toddler Meaningful Auditory Integration Scale, Speech Intelligibility Rating, and Categorized Auditory Performance were pooled using weighted mean differences, and a 95% confidence interval.

Results

Eighteen studies met the inclusion criteria. The differences between GJB2-related deafness and non- GJB2-related deafness due to unidentified causes and other types of genetic deafness without additional disabilities were not statistically significant ( P = .15 and P = .30, respectively); however, the difference between GJB2-related deafness and acquired hearing loss due to environmental etiologies was statistically significant and favored GJB2-related deafness ( P = .03).

Conclusion

GJB2-related deafness leads to significantly better cochlear implantation outcomes when compared with acquired deafness caused by environmental etiologies. However, GJB2 mutation is not associated with a significantly better prognosis when compared with those whose deafness results from either nonsyndromic hearing loss of unknown origin or other types of genetic mutations in the absence of other neurologic deficits.

Found

Top-30

Journals

	1 2 3
Ear and Hearing	Ear and Hearing, 3, 12.5% Ear and Hearing 3 publications, 12.5%
International Journal of Pediatric Otorhinolaryngology	International Journal of Pediatric Otorhinolaryngology, 2, 8.33% International Journal of Pediatric Otorhinolaryngology 2 publications, 8.33%
Laryngoscope investigative otolaryngology	Laryngoscope investigative otolaryngology, 2, 8.33% Laryngoscope investigative otolaryngology 2 publications, 8.33%
Zeitschrift fur Arbeits- und Organisationspsychologie	Zeitschrift fur Arbeits- und Organisationspsychologie, 1, 4.17% Zeitschrift fur Arbeits- und Organisationspsychologie 1 publication, 4.17%
ORL	ORL, 1, 4.17% ORL 1 publication, 4.17%
Otology and Neurotology	Otology and Neurotology, 1, 4.17% Otology and Neurotology 1 publication, 4.17%
Trends in hearing	Trends in hearing, 1, 4.17% Trends in hearing 1 publication, 4.17%
Journal of Clinical Medicine	Journal of Clinical Medicine, 1, 4.17% Journal of Clinical Medicine 1 publication, 4.17%
Children	Children, 1, 4.17% Children 1 publication, 4.17%
Frontiers in Cellular Neuroscience	Frontiers in Cellular Neuroscience, 1, 4.17% Frontiers in Cellular Neuroscience 1 publication, 4.17%
Genes	Genes, 1, 4.17% Genes 1 publication, 4.17%
Molecular Neurobiology	Molecular Neurobiology, 1, 4.17% Molecular Neurobiology 1 publication, 4.17%
JARO - Journal of the Association for Research in Otolaryngology	JARO - Journal of the Association for Research in Otolaryngology, 1, 4.17% JARO - Journal of the Association for Research in Otolaryngology 1 publication, 4.17%
Anatomical Record	Anatomical Record, 1, 4.17% Anatomical Record 1 publication, 4.17%
PLoS Biology	PLoS Biology, 1, 4.17% PLoS Biology 1 publication, 4.17%
European Journal of Human Genetics	European Journal of Human Genetics, 1, 4.17% European Journal of Human Genetics 1 publication, 4.17%
Expert Review of Molecular Diagnostics	Expert Review of Molecular Diagnostics, 1, 4.17% Expert Review of Molecular Diagnostics 1 publication, 4.17%
Cochlear Implants International	Cochlear Implants International, 1, 4.17% Cochlear Implants International 1 publication, 4.17%
	1 2 3

Publishers

	1 2 3 4
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 4, 16.67% Ovid Technologies (Wolters Kluwer Health) 4 publications, 16.67%
MDPI	MDPI, 3, 12.5% MDPI 3 publications, 12.5%
Springer Nature	Springer Nature, 3, 12.5% Springer Nature 3 publications, 12.5%
Wiley	Wiley, 3, 12.5% Wiley 3 publications, 12.5%
Elsevier	Elsevier, 2, 8.33% Elsevier 2 publications, 8.33%
Taylor & Francis	Taylor & Francis, 2, 8.33% Taylor & Francis 2 publications, 8.33%
Hogrefe Publishing Group	Hogrefe Publishing Group, 1, 4.17% Hogrefe Publishing Group 1 publication, 4.17%
S. Karger AG	S. Karger AG, 1, 4.17% S. Karger AG 1 publication, 4.17%
SAGE	SAGE, 1, 4.17% SAGE 1 publication, 4.17%
Frontiers Media S.A.	Frontiers Media S.A., 1, 4.17% Frontiers Media S.A. 1 publication, 4.17%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 4.17% Public Library of Science (PLoS) 1 publication, 4.17%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 1, 4.17% Cold Spring Harbor Laboratory 1 publication, 4.17%
	1 2 3 4

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Abdurehim Y. et al. Predictive Value of GJB2 Mutation Status for Hearing Outcomes of Pediatric Cochlear Implantation // Otolaryngology - Head and Neck Surgery. 2017. Vol. 157. No. 1. pp. 16-24.

GOST all authors (up to 50) Copy

Abdurehim Y., Lehmann A., Zeitouni A. Predictive Value of GJB2 Mutation Status for Hearing Outcomes of Pediatric Cochlear Implantation // Otolaryngology - Head and Neck Surgery. 2017. Vol. 157. No. 1. pp. 16-24.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1177/0194599817697054

UR - https://doi.org/10.1177/0194599817697054

TI - Predictive Value of GJB2 Mutation Status for Hearing Outcomes of Pediatric Cochlear Implantation

T2 - Otolaryngology - Head and Neck Surgery

AU - Abdurehim, Yasin

AU - Lehmann, Alexandre

AU - Zeitouni, Anthony

PY - 2017

DA - 2017/03/21

PB - SAGE

SP - 16-24

IS - 1

VL - 157

PMID - 28322114

SN - 0194-5998

SN - 1097-6817

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Abdurehim,

author = {Yasin Abdurehim and Alexandre Lehmann and Anthony Zeitouni},

title = {Predictive Value of GJB2 Mutation Status for Hearing Outcomes of Pediatric Cochlear Implantation},

journal = {Otolaryngology - Head and Neck Surgery},

year = {2017},

volume = {157},

publisher = {SAGE},

month = {mar},

url = {https://doi.org/10.1177/0194599817697054},

number = {1},

pages = {16--24},

doi = {10.1177/0194599817697054}

}

MLA

Cite this

MLA Copy

Abdurehim, Yasin, et al. “Predictive Value of GJB2 Mutation Status for Hearing Outcomes of Pediatric Cochlear Implantation.” Otolaryngology - Head and Neck Surgery, vol. 157, no. 1, Mar. 2017, pp. 16-24. https://doi.org/10.1177/0194599817697054.

Publisher

SAGE

Journal

Otolaryngology - Head and Neck Surgery

scimago Q1

wos Q1

SJR

0.987

CiteScore

4.8

Impact factor

2.5

ISSN

01945998 (Print)

10976817 (Electronic)