Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line μ-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS
YASUHIRO ITAGAKI
1
,
Tsuyoshi Fujita
1
,
Hideo NAOKI
1
,
Tadashi Yasuhara
2
,
Marta Andriantsiferana
3
,
Terumi NAKAJIMA
1
1
Suntory Institute for Bioorganic Research, Osaka, Japan.
|
3
Faculty of Science University of Antanarivo, Antanarivo, Madagascar
|
Publication type: Journal Article
Publication date: 2006-05-30
PubMed ID:
9086453
Toxicology
Abstract
Spider venom glands store various novel neurotoxic acylpolyamines which present potent and irreversible inhibition of the glutamatergic synapses. We have developed a new highly sensitive analytical method to detect and characterize structures of those neurotoxins stored in a single venom gland using micro bore column high performance liquid chromatography (HPLC)-continuous flow FRIT fast atom bombardment mass spectrometry (HPLC-FAB/MS) and tandem mass spectrometry (MS/MS) array detection system. The high-energy collision induced dissociation (CID) spectra of sodium cationized spider toxins produced very strong structurally informative product ions which afforded the location of nitrogen atoms and the connectivity of methylene units within the polyamines. This methodology permitted detection of 40 amino acid containing acylpolyamines in the venom of Nephilengys borbonica from which structures of only five compounds were previously known. Nat. Toxins 5:1–13, 1997. © 1997 Wiley-Liss, Inc.
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Total citations:
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GOST
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ITAGAKI Y. et al. Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line μ-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS // Natural Toxins. 2006. Vol. 5. No. 1. pp. 1-13.
GOST all authors (up to 50)
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ITAGAKI Y., Fujita T., NAOKI H., Yasuhara T., Andriantsiferana M., NAKAJIMA T. Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line μ-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS // Natural Toxins. 2006. Vol. 5. No. 1. pp. 1-13.
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TY - JOUR
DO - 10.1002/(sici)(1997)5:1<1::aid-nt1>3.0.co;2-8
UR - https://doi.org/10.1002/(sici)(1997)5:1<1::aid-nt1>3.0.co;2-8
TI - Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line μ-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS
T2 - Natural Toxins
AU - ITAGAKI, YASUHIRO
AU - Fujita, Tsuyoshi
AU - NAOKI, Hideo
AU - Yasuhara, Tadashi
AU - Andriantsiferana, Marta
AU - NAKAJIMA, Terumi
PY - 2006
DA - 2006/05/30
PB - Wiley
SP - 1-13
IS - 1
VL - 5
PMID - 9086453
SN - 1056-9014
SN - 1522-7189
ER -
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BibTex (up to 50 authors)
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@article{2006_ITAGAKI,
author = {YASUHIRO ITAGAKI and Tsuyoshi Fujita and Hideo NAOKI and Tadashi Yasuhara and Marta Andriantsiferana and Terumi NAKAJIMA},
title = {Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line μ-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS},
journal = {Natural Toxins},
year = {2006},
volume = {5},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002/(sici)(1997)5:1<1::aid-nt1>3.0.co;2-8},
number = {1},
pages = {1--13},
doi = {10.1002/(sici)(1997)5:1<1::aid-nt1>3.0.co;2-8}
}
Cite this
MLA
Copy
ITAGAKI, YASUHIRO, et al. “Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line μ-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS.” Natural Toxins, vol. 5, no. 1, May. 2006, pp. 1-13. https://doi.org/10.1002/(sici)(1997)5:1<1::aid-nt1>3.0.co;2-8.