Schöllkopf Oxazole Synthesis

The formation of a 2‐unsubstituted oxazole derivative by the condensation of an α‐metalated isocyanide with an acylating reagent is generally referred to as the Schöllkopf oxazole synthesis. It has been observed that during this reaction, the intermediate of α‐isocyanoketone is not isolable, and cyclizes to give oxazole at the workup stage. This reaction has the importance because it synthesize high yield of amino esters and amino ketones. Besides the formation of oxazole derivatives, this reaction has been successfully extended the α‐alkali metalated isocyanides to the formation of the chain‐extended primary amines and oxazoline. This reaction has been used in the preparation of oxazole derivatives.