Coronary Drug Project

The Coronary Drug Project (CDP) was a randomized, double-blind, placebo-controlled clinical trial of the efficacy and safety of five lipid-modifying agents in men with previous myocardial infarction (MI). The patients were followed for a minimum of 5 years to determine whether pharmaceutical modification of blood lipids would lead to improved survival and a reduction in cardiovascular (CV) mortality and morbidity. A secondary objective was to identify baseline prognostic factors for CV mortality and morbidity in the placebo group of patients. This chapter describes the study design and methods used in the CDP. It then presents results of the project. Finally, the chapter presents conclusions and lessons learned form the project.