4b Electrophilic Aromatic Substitution

Chapter 4 4b Electrophilic Aromatic Substitution G. W. Weaver, G. W. Weaver Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UKSearch for more papers by this author G. W. Weaver, G. W. Weaver Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UKSearch for more papers by this author Book Editor(s):Mark Moloney, Mark Moloney University of Oxford, Mansfield Road, Oxford, UK, OX1 3TA United KingdomSearch for more papers by this author First published: 15 March 2024 https://doi.org/10.1002/9781119716846.ch4bBook Series:Organic Reaction Mechanisms Series AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onEmailFacebookTwitterLinkedInRedditWechat Summary Functionalized arenes and heterocycles continue to serve as essential compounds in industry and academic research. Electrophilic aromatic substitution (EAS) remains one of the most important processes for introducing the diverse array of functionality required for new applications, and novel synthetic methods and investigations into the underlying mechanisms of EAS reactions continue to receive much attention. There is a growing use of artificial intelligence and machine learning to assist in identifying likely products of reactions or the best conditions to apply in synthesis. Improved methods for halogenation continue to be an important area of investigation in EAS. Studies on the mechanisms of new bromination methods continue to receive attention. Mechanisms for reactions to introduce sulfur-containing functionality have appeared. Metals are key to many electrophilic substitution processes as catalysts or stoichiometric reagents, and C–H insertion reactions feature prominently. References Makosza , M. , Chem. – Eur. 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