Dansyl Based AIE Material for Multimodal Recognition of Antibiotics

A dansyl‐isoniazid conjugate (DISH) is designed and synthesized which exhibits Aggregation‐Induced Emission (AIE) in MeOH : H₂O (20 : 80). This AIE Material is utilized for detection of different antibiotics having carboxylic acid, amide and thioamide functionalities. The material shows a multimodal recognition behaviour having maximum affinity with a fluorescence intensification (236 %) (φ=0.68) on addition of 2.0 μM levofloxacin (LEV) whereas the quenching of fluorescence emission is observed on addition of prothionamide (PTH) (8.0 μM). To test the practical application of the DISH, we performed smartphone‐based detection wherein RGB colour picker app is used to study the colour variation of probe in urine samples spiked with same concentration of LEV (2.0 μM) and PTH (8.0 μM).