Wiley
Angewandte Chemie
,  volume 137 ,  issue 6 ,  publication number e202418239

Solvent‐Dependent Divergent Cyclization of Bicyclo[1.1.0]butanes

Publication type: Journal Article
Publication date: 2025-01-05
Wiley
SJR: —
CiteScore: —
Impact factor: —
ISSN: 00448249, 15213757
Abstract

Bicyclo[1.1.0]butanes (BCBs) have recently garnered significant research interest as versatile precursors for synthesizing potential [n.1.1] bioisosteres and multi‐functionalized cyclobutanes in a straightforward and atom‐economical manner. Here, we report a solvent‐dependent divergent cyclization of BCBs that providecs highly diastereospecific decorated cyclobutanes and oxygen‐containing bicyclo[3.1.1]heptanes (BCHeps), which serve as bioisosteres of meta‐substituted arenes. This novel strategy employs precision‐oriented control to achieve the desired divergence. Additionally, an unprecedented 1,2‐difunctionalization reaction mode for BCBs was explore, expanding the available methods for efficiently exploring the chemical space of arene bioisosteres and highly functionalized cyclobutanes.

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Zhang F. et al. Solvent‐Dependent Divergent Cyclization of Bicyclo[1.1.0]butanes // Angewandte Chemie. 2025. Vol. 137. No. 6. e202418239
GOST all authors (up to 50) Copy
Zhang F., Dutta S., Petti A., Rana D., Daniliuc C. G., Glorius F. Solvent‐Dependent Divergent Cyclization of Bicyclo[1.1.0]butanes // Angewandte Chemie. 2025. Vol. 137. No. 6. e202418239
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TY - JOUR
DO - 10.1002/ange.202418239
UR - https://onlinelibrary.wiley.com/doi/10.1002/ange.202418239
TI - Solvent‐Dependent Divergent Cyclization of Bicyclo[1.1.0]butanes
T2 - Angewandte Chemie
AU - Zhang, Fuhao
AU - Dutta, Subhabrata
AU - Petti, Alessia
AU - Rana, Debanjan
AU - Daniliuc, Constantin G.
AU - Glorius, Frank
PY - 2025
DA - 2025/01/05
PB - Wiley
IS - 6
VL - 137
SN - 0044-8249
SN - 1521-3757
ER -
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Cite this
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@article{2025_Zhang,
author = {Fuhao Zhang and Subhabrata Dutta and Alessia Petti and Debanjan Rana and Constantin G. Daniliuc and Frank Glorius},
title = {Solvent‐Dependent Divergent Cyclization of Bicyclo[1.1.0]butanes},
journal = {Angewandte Chemie},
year = {2025},
volume = {137},
publisher = {Wiley},
month = {jan},
url = {https://onlinelibrary.wiley.com/doi/10.1002/ange.202418239},
number = {6},
pages = {e202418239},
doi = {10.1002/ange.202418239}
}